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Loratadine structure, CAS 79794-75-5

Loratadine

CAS Number79794-75-5

SynonymsMFCD00672869; CLARATYNE; Ethyl-4-(8-chlor-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yliden)piperidin-1-carboxylat; Loratadine; Flonidan; Claritine; Loranox; CLARITIN; Tadine; Klaritin; Civeran; Clarityn; Cronopen; Lisino

Molecular FormulaC22H23ClN2O2

Molecular Weight382.88

Purity99%

Density1.3±0.1 g/cm3

Boiling Point531.3±50.0 °C at 760 mmHg

Melting Point134-136°C

Flash Point

Appearancewhite powder

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MSDSChineseEnglish

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Cat. No.: 2A-9011232 Purity: 99%
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Quality Control of [ 79794-75-5 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number79794-75-5
Catalog No.2A-9011232
Chinese Name氯雷他定
SynonymsMFCD00672869; CLARATYNE; Ethyl-4-(8-chlor-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yliden)piperidin-1-carboxylat; Loratadine; Flonidan; Claritine; Loranox; CLARITIN; Tadine; Klaritin; Civeran; Clarityn; Cronopen; Lisino
Molecular FormulaC22H23ClN2O2
Molecular Weight382.88
Purity99
Density1.3±0.1 g/cm3
Boiling Point531.3±50.0 °C at 760 mmHg
Melting Point134-136°C
Appearancewhite powder
Water SolubilityDMSO: 26 mg/mL, soluble
Storage Condition2-8°C
ApplicationLoratadine (SCH-29851) is an H1 receptor inverse agonist with IC50>32 μM.
HTC2933990090
PubChem ID329823353
MDL NumberMFCD00672869
SMILESCCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
InChI1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI KeyJCCNYMKQOSZNPW-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/11232_1_79794_75_5.pdf
BioactivityLoratadine(SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.IC50 value: 32 uMTarget: H1-receptorLoratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Kay GG, Harris AG. Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clin Exp Allergy. 1999 Jul;29 Suppl 3:147-50. [2]. Menardo JL, Horak F, Danzig MR, Czarlewski W. A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4. [3]. Monroe EW. Loratadine in the treatment of urticaria. Clin Ther. 1997 Mar-Apr;19(2):232-42. [4]. Haria M, Fitton A, Peters DH. Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders. Drugs. 1994 Oct;48(4):617-37. [5]. Roman IJ, Danzig MR. Loratadine. A review of recent findings in pharmacology, pharmacokinetics, efficacy, and safety, with a look at its use in combination with pseudoephedrine. Clin Rev Allergy. 1993 Spring;11(1):89-110. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 531.3±50.0 °C at 760 mmHg Melting Point 134-136°C Molecular Formula C22H23ClN2O2 Molecular Weight 382.883 Flash Point 275.1±30.1 °C Exact Mass 382.144806 PSA 42.43000 LogP 5.94 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.614 InChIKey JCCNYMKQOSZNPW-UHFFFAOYSA-N SMILES CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 Storage condition 2-8°C Stability Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents. Water Solubility DMSO: 26 mg/mL, soluble
Use ofLoratadine(SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.IC50 value: 32 uMTarget: H1-receptorLoratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Properties Articles63 Name Loratadine Synonym More Synonyms Loratadine Biological Activity Description Loratadine(SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.IC50 value: 32 uMTarget: H1-receptorLoratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Kay GG, Harris AG. Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clin Exp Allergy. 1999 Jul;29 Suppl 3:147-50. [2]. Menardo JL, Horak F, Danzig MR, Czarlewski W. A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4. [3]. Monroe EW. Loratadine in the treatment of urticaria. Clin Ther. 1997 Mar-Apr;19(2):232-42. [4]. Haria M, Fitton A, Peters DH. Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders. Drugs. 1994 Oct;48(4):617-37. [5]. Roman IJ, Danzig MR. Loratadine. A review of recent findings in pharmacology, pharmacokinetics, efficacy, and safety, with a look at its use in combination with pseudoephedrine. Clin Rev Allergy. 1993 Spring;11(1):89-110. Chemical & Physical Properties Exact Mass 382.144806 PSA 42.43000 Index of Refraction 1.614 InChIKey JCCNYMKQOSZNPW-UHFFFAOYSA-N Stability Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents.
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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