CAS Number34552-83-5
SynonymsImosec; 1-piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-, hydrochloride (1:1); Fortasec; 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride; LOPERAMIDE HCL; LoperaMide Hydrochloride; 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide,hydrochloride; 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, hydrochloride (1:1); Suprasec; Dissenten; MFCD00058581; arret; 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride; Lopemin; BREK; EINECS 252-082-4; BLOX; Lopemid; Loperyl; 4-[4-(4-Chlorphenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamidhydrochlorid; 4-[4-(4-chlorophényl)-4-hydroxypipéridin-1-yl]-N,
Molecular FormulaC29H34Cl2N2O2
Molecular Weight513.50
Purity99%
Boiling Point647.2ºC at 760 mmHg
Melting Point223-225°C
AppearanceCrystal, almost soluble in water
EINECS252-082-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 34552-83-5 |
| Catalog No. | 2A-9011227 |
| Chinese Name | 盐酸洛哌丁胺 |
| Synonyms | Imosec; 1-piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-, hydrochloride (1:1); Fortasec; 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride; LOPERAMIDE HCL; LoperaMide Hydrochloride; 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide,hydrochloride; 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, hydrochloride (1:1); Suprasec; Dissenten; MFCD00058581; arret; 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride; Lopemin; BREK; EINECS 252-082-4; BLOX; Lopemid; Loperyl; 4-[4-(4-Chlorphenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamidhydrochlorid; 4-[4-(4-chlorophényl)-4-hydroxypipéridin-1-yl]-N, |
| Molecular Formula | C29H34Cl2N2O2 |
| Molecular Weight | 513.50 |
| Purity | 99 |
| Boiling Point | 647.2ºC at 760 mmHg |
| Melting Point | 223-225°C |
| Appearance | Crystal, almost soluble in water |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Packaging | III |
| Application | Loperamide hydrochloride is an opiate agonist used to treat diarrhea. |
| EINECS | 252-082-4 |
| PubChem ID | 24278042 |
| MDL Number | MFCD00058581 |
| SMILES | Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4 |
| InChI | 1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H |
| InChI Key | PGYPOBZJRVSMDS-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11227_1_34552_83_5.pdf |
| Bioactivity | Loperamide hydrochloride is an opiate receptor agonist for the treatment of diarrhea. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease References [1]. Hanauer, S.B., The role of loperamide in gastrointestinal disorders. Rev Gastroenterol Disord, 2008. 8(1): p. 15-20. [2]. Litovitz, T., et al., Surveillance of loperamide ingestions: an analysis of 216 poison center reports. J Toxicol Clin Toxicol, 1997. 35(1): p. 11-9. [3]. http://www.drugs.com/mmx/loperamide-hydrochloride.html Chemical & Physical Properties Boiling Point 647.2ºC at 760 mmHg Melting Point 223-225°C Molecular Formula C29H34Cl2N2O2 Molecular Weight 513.498 Flash Point 345.2ºC Exact Mass 512.199707 PSA 43.78000 LogP 5.82790 InChIKey PGYPOBZJRVSMDS-UHFFFAOYSA-N SMILES CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1.Cl Storage condition Store at RT |
| Use of | Loperamide hydrochloride is an opiate receptor agonist for the treatment of diarrhea. Properties Articles54 Name loperamide hydrochloride Synonym More Synonyms Loperamide hydrochloride Biological Activity Description Loperamide hydrochloride is an opiate receptor agonist for the treatment of diarrhea. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease References [1]. Hanauer, S.B., The role of loperamide in gastrointestinal disorders. Rev Gastroenterol Disord, 2008. 8(1): p. 15-20. [2]. Litovitz, T., et al., Surveillance of loperamide ingestions: an analysis of 216 poison center reports. J Toxicol Clin Toxicol, 1997. 35(1): p. 11-9. [3]. http://www.drugs.com/mmx/loperamide-hydrochloride.html Chemical & Physical Properties Exact Mass 512.199707 PSA 43.78000 LogP 5.82790 InChIKey PGYPOBZJRVSMDS-UHFFFAOYSA-N Storage condition Store at RT |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European land transport hazard regulations: TOXIC SOLID, ORGANIC, N.O.S. (4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α- diphenylpiperidine-1-butyramide monohydrochloride) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α- diphenylpiperidine-1-butyramide monohydrochloride) International air transport hazard regulations: Toxic solid, organic, n.o.s. (4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α- diphenylpiperidine-1-butyramide monohydrochloride) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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