CAS Number98079-52-8
Synonyms1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,hydrochloride; MFCD00214312; Lomefloxacin hydrochloride; Lomefloxacin (hydrochloride)
Molecular FormulaC17H20ClF2N3O3
Molecular Weight387.81
Purity90%
Boiling Point542.7ºC at 760 mmHg
Melting Point290-3000C
Appearancewhite powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 98079-52-8 |
| Catalog No. | 2A-9011219 |
| Chinese Name | 盐酸洛美沙星 |
| Synonyms | 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,hydrochloride; MFCD00214312; Lomefloxacin hydrochloride; Lomefloxacin (hydrochloride) |
| Molecular Formula | C17H20ClF2N3O3 |
| Molecular Weight | 387.81 |
| Purity | 90 |
| Boiling Point | 542.7ºC at 760 mmHg |
| Melting Point | 290-3000C |
| Appearance | white powder |
| Storage Condition | Sealed and stored in a cool, dry warehouse. |
| Application | Lomefloxacin hydrochloride is a fluoroquinolone antibiotic. |
| HTC | 2933990090 |
| PubChem ID | 24278514 |
| MDL Number | MFCD00214312 |
| SMILES | Cl.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12 |
| InChI | 1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H |
| InChI Key | KXEBLAPZMOQCKO-UHFFFAOYSA-N |
| NACRES Code | NA.85 |
| UNSPSC | 51282927 |
| MSDS | msds/11219_1_98079_52_8.pdf |
| Bioactivity | Lomefloxacin HCl is a fluoroquinolone antibiotic.Target: AntibacterialLomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited [1]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. http://www.drugbank.ca/drugs/DB00978 Chemical & Physical Properties Boiling Point 542.7ºC at 760 mmHg Melting Point 290-3000C Molecular Formula C17H20ClF2N3O3 Molecular Weight 387.809 Flash Point 282ºC Exact Mass 387.116119 PSA 74.57000 LogP 2.99170 InChIKey KXEBLAPZMOQCKO-UHFFFAOYSA-N SMILES CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c21.Cl Storage condition −20°C |
| Use of | Lomefloxacin HCl is a fluoroquinolone antibiotic.Target: AntibacterialLomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited [1]. Properties Articles28 Name lomefloxacin hydrochloride Synonym More Synonyms Lomefloxacin hydrochloride Biological Activity Description Lomefloxacin HCl is a fluoroquinolone antibiotic.Target: AntibacterialLomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited [1]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. http://www.drugbank.ca/drugs/DB00978 Chemical & Physical Properties Exact Mass 387.116119 PSA 74.57000 LogP 2.99170 InChIKey KXEBLAPZMOQCKO-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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