CAS Number21498-08-8
Synonyms2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole hydrochloride (1:1); Lofexidine HCl; 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole,hydrochloride; RMI 14042A; 1H-Imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, hydrochloride (1:1); Lofexidine hydrochloride; UNII:V47G1SDI1B; MFCD00917022; 2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole Monohydrochloride; (±)-2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline Hydrochloride
Molecular FormulaC11H13Cl3N2O
Molecular Weight295.59
Purity≥98 (HPLC)%
Boiling Point421.5ºC at 760 mmHg
Melting Point230-232ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 21498-08-8 |
| Catalog No. | 2A-9011213 |
| Chinese Name | 盐酸洛非西定 |
| Synonyms | 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole hydrochloride (1:1); Lofexidine HCl; 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole,hydrochloride; RMI 14042A; 1H-Imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, hydrochloride (1:1); Lofexidine hydrochloride; UNII:V47G1SDI1B; MFCD00917022; 2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole Monohydrochloride; (±)-2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline Hydrochloride |
| Molecular Formula | C11H13Cl3N2O |
| Molecular Weight | 295.59 |
| Purity | ≥98 (HPLC) |
| Boiling Point | 421.5ºC at 760 mmHg |
| Melting Point | 230-232ºC |
| Appearance | powder |
| Storage Condition | -20°C Freezer |
| Application | Lofexidine hydrochloride is an α2A adrenergic receptor agonist commonly used to relieve the physical symptoms of heroin and other opioid withdrawal. |
| HTC | 2933290090 |
| SMILES | CC(Oc1c(Cl)cccc1Cl)C1=NCCN1.Cl |
| InChI | 1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H |
| InChI Key | DWWHMKBNNNZGHF-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1 |
| MSDS | msds/11213_1_21498_08_8.pdf |
| Bioactivity | Lofexidine hydrochloride is an α2A-adrenergic receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease Chemical & Physical Properties Boiling Point 421.5ºC at 760 mmHg Melting Point 230-232ºC Molecular Formula C11H13Cl3N2O Molecular Weight 295.593 Flash Point 208.7ºC Exact Mass 294.009338 PSA 33.62000 LogP 3.32880 Vapour Pressure 6.35E-07mmHg at 25°C InChIKey DWWHMKBNNNZGHF-UHFFFAOYSA-N SMILES CC(Oc1c(Cl)cccc1Cl)C1=NCCN1.Cl Storage condition -20°C Freezer |
| Use of | Lofexidine hydrochloride is an α2A-adrenergic receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal. Properties Name Lofexidine Hydrochloride Synonym More Synonyms Lofexidine hydrochloride Biological Activity Description Lofexidine hydrochloride is an α2A-adrenergic receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease Chemical & Physical Properties Exact Mass 294.009338 PSA 33.62000 LogP 3.32880 InChIKey DWWHMKBNNNZGHF-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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