| Chemical & Physical Properties | |
|---|---|
| CAS Number | 26786-32-3 |
| Catalog No. | 2A-9011211 |
| Chinese Name | 盐酸洛非帕明 |
| Synonyms | Lofepramine hydrochloride |
| Molecular Formula | C26H28Cl2N2O |
| Molecular Weight | 455.42 |
| Purity | 98 |
| Boiling Point | 575ºC at 760 mmHg |
| Appearance | powder |
| Application | Lofepropylamine hydrochloride is a potent tricyclic antidepressant that is extensively metabolized to deceptamide. The antidepressant activity of lofepropylamine hydrochloride results from promotion o |
| EINECS | 248-002-2 |
| MDL Number | MFCD00941486 |
| SMILES | Cl[H].CN(CCCN1c2ccccc2CCc3ccccc13)CC(=O)c4ccc(Cl)cc4 |
| InChI | 1S/C26H27ClN2O.ClH/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29;/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3;1H |
| InChI Key | ZWZIQPOLMDPIQM-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/11211_1_26786_32_3.pdf |
| Bioactivity | Lofepramine (Lopramine) hydrochloride is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine hydrochloride stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine hydrochloride may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine hydrochloride has significant anxiolytic efficacy in addition to its antidepressant properties[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Lancaster SG, et al. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Feb;37(2):123-40. Chemical & Physical Properties Boiling Point 575ºC at 760 mmHg Molecular Formula C26H28Cl2N2O Molecular Weight 455.42 Flash Point 301.6ºC Exact Mass 454.15800 PSA 23.55000 LogP 6.64850 Vapour Pressure 3.17E-13mmHg at 25°C InChIKey ZWZIQPOLMDPIQM-UHFFFAOYSA-N SMILES CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1.Cl |
| Use of | Lofepramine (Lopramine) hydrochloride is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine hydrochloride stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine hydrochloride may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine hydrochloride has significant anxiolytic efficacy in addition to its antidepressant properties[1]. Properties Name lofepramine hydrochloride Synonym More Synonyms LOFEPRAMINE HYDROCHLORIDE Biological Activity Description Lofepramine (Lopramine) hydrochloride is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine hydrochloride stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine hydrochloride may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine hydrochloride has significant anxiolytic efficacy in addition to its antidepressant properties[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Lancaster SG, et al. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Feb;37(2):123-40. Chemical & Physical Properties Exact Mass 454.15800 PSA 23.55000 LogP 6.64850 InChIKey ZWZIQPOLMDPIQM-UHFFFAOYSA-N |
| Transport Info | Product name: Lofepramine hydrochloride |
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