CAS Number98079-51-7
Synonyms1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; LFLX; Lomefloxacin; Lomefloxacinum; (±)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid; 1-Ethyl-6,8-difluoro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; Maxaquin; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; UNII:L6BR2WJD8V; Lomefloxacino; MFCD00242673; Lomefloxacine
Molecular FormulaC17H19O3N3F2
Molecular Weight351.35
Purity99%
Density1.3±0.1 g/cm3
Boiling Point542.7±50.0 °C at 760 mmHg
Melting Point239-240ºC
AppearanceOff-white to yellow crystals
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 98079-51-7 |
| Catalog No. | 2A-9011218 |
| Chinese Name | 洛美沙星 |
| Synonyms | 1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; LFLX; Lomefloxacin; Lomefloxacinum; (±)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid; 1-Ethyl-6,8-difluoro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; Maxaquin; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; UNII:L6BR2WJD8V; Lomefloxacino; MFCD00242673; Lomefloxacine |
| Molecular Formula | C17H19O3N3F2 |
| Molecular Weight | 351.35 |
| Purity | 99 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 542.7±50.0 °C at 760 mmHg |
| Melting Point | 239-240ºC |
| Appearance | Off-white to yellow crystals |
| Storage Condition | −20°C |
| Application | Lomefloxacin (SC47111A) is a fluoroquinolone antibiotic. |
| HTC | 2933990090 |
| MDL Number | MFCD00242673 |
| SMILES | CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c21 |
| InChI | InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25) |
| InChI Key | ZEKZLJVOYLTDKK-UHFFFAOYSA-N |
| MSDS | msds/11218_1_98079_51_7.pdf |
| Use of | Lomefloxacin(SC47111A) is a fluoroquinolone antibiotic.Target: AntibacterialLomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited [1]. Properties Name lomefloxacin Synonym More Synonyms Lomefloxacin Biological Activity Description Lomefloxacin(SC47111A) is a fluoroquinolone antibiotic.Target: AntibacterialLomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited [1]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. http://www.drugbank.ca/drugs/DB00978 Chemical & Physical Properties Molecular Formula C17H19F2N3O3 Exact Mass 351.139435 PSA 74.57000 Index of Refraction 1.566 InChIKey ZEKZLJVOYLTDKK-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-pipera zinyl)-4-oxo- CAS REGISTRY NUMBER : 98079-51-7 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C17-H19-F2-N3-O3 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - excitement TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - changes in motor activity (specific assay) Behavioral - ataxia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : REFERENCE : AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 37,213,1993 Safety Information Hazard Codes Xn,Xi Safety Phrases S26-S36 WGK Germany 3 RTECS VB1997500 HS Code 2933990090 Synthetic Route Total: 1 Page 2-Methylpiperazine CAS#:109-07-9 Ethyl 1-ethyl-6... CAS#:100501-62-0 Lomefloxacin CAS#:98079-51-7 1-Ethy-6,7,8-tr... CAS#:75338-42-0 2-Methylpiperazine CAS#:109-07-9 Lomefloxacin CAS#:98079-51-7 Literature: Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154 Lomefloxacin CAS#:98079-51-7 Lomefloxacin CAS#:98079-51-7 Literature: Journal of Chemical Crystallography, , vol. 39, # 5 p. 384 - 388 Precursor & DownStream Precursor 4 CAS#:109-07-9 2-Methylpiperazine CAS#:100501-62-0 Ethyl 1-ethyl-6... CAS#:75338-42-0 1-Ethy-6,7,8-tr... CAS#:98079-51-7 Lomefloxacin DownStream 1 CAS#:98079-51-7 Lomefloxacin |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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