CAS Number17605-67-3
Synonymstrans-24-Ethylidenecholesterol; D5-avenasterol; MFCD00037543; FUCOSTEROL; Fucosterin; trans-Stigmasta-5,24(28)-dien-3b-ol; 24-ETHYLIDENCHOLEST-5-ENE-3B-OL
Molecular FormulaC29H48O
Molecular Weight412.69
Purity≥93%
Density0.98 g/cm3
Boiling Point504.2ºC at 760 mmHg
Melting Point118-120ºC
Appearancewhite powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 17605-67-3 |
| Catalog No. | 2A-9010644 |
| Chinese Name | 岩藻甾醇 |
| Synonyms | trans-24-Ethylidenecholesterol; D5-avenasterol; MFCD00037543; FUCOSTEROL; Fucosterin; trans-Stigmasta-5,24(28)-dien-3b-ol; 24-ETHYLIDENCHOLEST-5-ENE-3B-OL |
| Molecular Formula | C29H48O |
| Molecular Weight | 412.69 |
| Purity | ≥93 |
| Density | 0.98 g/cm3 |
| Boiling Point | 504.2ºC at 760 mmHg |
| Melting Point | 118-120ºC |
| Appearance | white powder |
| Storage Condition | 2-8°C |
| Application | Fucosterol is isolated from E. stolonifera and has anti-adipogenic, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis by modulating the expression of PPARα and C/EBPα. |
| PubChem ID | 24894886 |
| MDL Number | MFCD00037543 |
| SMILES | C\C=C(/CC[C@H](C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C |
| InChI | 1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h7,10,19-20,23-27,30H,8-9,11-18H2,1-6H3/b21-7+ |
| InChI Key | OSELKOCHBMDKEJ-QPSGOUHRSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 41116107 |
| MSDS | msds/10644_1_17605_67_3.pdf |
| Bioactivity | Fucosterol is isolated from E. stolonifera with anti-adipogenic, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis via modulation of PPARαand C/EBPαexpression. Related Catalog Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Target PPARα; C/EBPα[1] In Vitro Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes[1].Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC50 values of 27.94 and 70.41 μg/ml, respectively[3]. Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC50 values of 185.4, 43.3, and 34.0 µg/ml, respectively[4]. Cell Viability Assay[1] Cell Line: 3T3-L1 adipocytes Concentration: 0 μM; 25 μM; 50 μM Incubation Time: 7 days Result: Inhibited PPARα and C/EBPα expression. In Vivo Fucosterol (orally adminstratin; 30mg/kg) causes a significant decrease in serum glucose concentrations, and exhibits an inhibition of sorbitol accumulations in the lenses[2]. References [1]. Jung HA, et al. Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res. 2014 Jun;37(6):713-20. [2]. Lee YS, et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa. Arch Pharm Res. 2004 Nov;27(11):1120-2. [3]. Khanavi M, et al. Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. Pharmacogn Mag. 2012 Jan;8(29):60-4. [4]. Caamal-Fuentes E, et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata. Pharm Biol. 2014 Oct;52(10):1244-8. Chemical & Physical Properties Density 0.98 g/cm3 Boiling Point 504.2ºC at 760 mmHg Melting Point 118-120ºC Molecular Formula C29H48O Molecular Weight 412.69100 Flash Point 220.3ºC Exact Mass 412.37100 PSA 20.23000 LogP 7.94490 Vapour Pressure 2.8E-12mmHg at 25°C Index of Refraction 1.53 InChIKey OSELKOCHBMDKEJ-HRKULPSGSA-N SMILES CC=C(CCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C Storage condition 2-8°C |
| Use of | Fucosterol is isolated from E. stolonifera with anti-adipogenic, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis via modulation of PPARαand C/EBPαexpression. Properties Articles27 Name fucosterol Synonym More Synonyms Fucosterol Biological Activity Description Fucosterol is isolated from E. stolonifera with anti-adipogenic, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis via modulation of PPARαand C/EBPαexpression. Related Catalog Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP PPARα; C/EBPα[1] References [1]. Jung HA, et al. Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res. 2014 Jun;37(6):713-20. [2]. Lee YS, et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa. Arch Pharm Res. 2004 Nov;27(11):1120-2. [3]. Khanavi M, et al. Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. Pharmacogn Mag. 2012 Jan;8(29):60-4. [4]. Caamal-Fuentes E, et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata. Pharm Biol. 2014 Oct;52(10):1244-8. Chemical & Physical Properties Molecular Formula C29H48O Exact Mass 412.37100 PSA 20.23000 LogP 7.94490 Index of Refraction 1.53 InChIKey OSELKOCHBMDKEJ-HRKULPSGSA-N |
| Transport Info | Product name: Fucosterol |
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