CAS Number531-75-9
SynonymsCrataegin; 7-Hydroxy-2-oxo-2H-chromen-6-yl β-D-glucopyranoside; EINECS 208-517-5; Enallachrome; vitaminc2; Esculetin 6-β-D-glucoside; POLYDROM; Bicolorin; Esculetin 6-O-glucoside; Polychrom; 7-Hydroxy-2-oxo-2H-chromen-6-yl-β-D-glucopyranoside; BICOLOIN; 7-Hydroxycoumarin-6-yl β-D-Glucopyranoside Sesquihydrate; Esculin; Polychrome; 6-(β-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one; Esculetin 6-b-D-glucoside; 7-Hydroxy-2-oxo-2H-chromen-6-yl β-D-glucopyranoside hydrate (1:1); Aesculin; MFCD00006879; Esculetin-6-O-glucoside; 2H-1-Benzopyran-2-one, 6-(β-D-glucopyranosyloxy)-7-hydroxy-, hydrate (1:1); Escosyl
Molecular FormulaC15H16O9
Molecular Weight340.28 (anhydrous basis)
Purity≥98%
Density1.7±0.1 g/cm3
Boiling Point697.7±55.0 °C at 760 mmHg
Melting Point203 °C
Appearancecream powder
EINECS208-517-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 531-75-9 |
| Catalog No. | 2A-9010379 |
| Chinese Name | 秦皮甲素 |
| Synonyms | Crataegin; 7-Hydroxy-2-oxo-2H-chromen-6-yl β-D-glucopyranoside; EINECS 208-517-5; Enallachrome; vitaminc2; Esculetin 6-β-D-glucoside; POLYDROM; Bicolorin; Esculetin 6-O-glucoside; Polychrom; 7-Hydroxy-2-oxo-2H-chromen-6-yl-β-D-glucopyranoside; BICOLOIN; 7-Hydroxycoumarin-6-yl β-D-Glucopyranoside Sesquihydrate; Esculin; Polychrome; 6-(β-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one; Esculetin 6-b-D-glucoside; 7-Hydroxy-2-oxo-2H-chromen-6-yl β-D-glucopyranoside hydrate (1:1); Aesculin; MFCD00006879; Esculetin-6-O-glucoside; 2H-1-Benzopyran-2-one, 6-(β-D-glucopyranosyloxy)-7-hydroxy-, hydrate (1:1); Escosyl |
| Molecular Formula | C15H16O9 |
| Molecular Weight | 340.28 (anhydrous basis) |
| Purity | ≥98 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 697.7±55.0 °C at 760 mmHg |
| Melting Point | 203 °C |
| Appearance | cream powder |
| Water Solubility | MODERATELY SOLUBLE |
| Storage Condition | 1. Store in a cool, dry and well-ventilated wareho |
| Application | Esculin is a fluorescent coumarin glucoside, an active ingredient in ash bark. Esculin improves cognitive impairment in experimental diabetic nephropathy (DN) through the MAPK signaling pathway and ex |
| EINECS | 208-517-5 |
| HTC | 2942000000 |
| PubChem ID | 24894668 |
| MDL Number | MFCD00149492 |
| SMILES | O.OC[C@H]1O[C@@H](Oc2cc3C=CC(=O)Oc3cc2O)[C@H](O)[C@@H](O)[C@@H]1O |
| InChI | 1S/C15H16O9.H2O/c16-5-10-12(19)13(20)14(21)15(24-10)23-9-3-6-1-2-11(18)22-8(6)4-7(9)17;/h1-4,10,12-17,19-21H,5H2;1H2/t10-,12-,13+,14-,15-;/m1./s1 |
| InChI Key | CQYPGSKIFJFVDQ-QWFKVUSTSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352201 |
| Hazard Symbols | Transport |
| MSDS | msds/10379_1_531_75_9.pdf |
| Bioactivity | Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark[1]. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway[2]. Related Catalog Research Areas >> Cancer Target p38 MAPK References [1]. Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct;178(2):795-807. [2]. Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May;17(5):7395-7402. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 697.7±55.0 °C at 760 mmHg Melting Point 203 °C Molecular Formula C15H16O9 Molecular Weight 340.29 Flash Point 262.8±25.0 °C PSA 149.82000 LogP -1.52 Vapour Pressure 0.0±2.3 mmHg at 25°C Index of Refraction 1.689 InChIKey XHCADAYNFIFUHF-TVKJYDDYSA-N SMILES O=c1ccc2cc(OC3OC(CO)C(O)C(O)C3O)c(O)cc2o1 Water Solubility MODERATELY SOLUBLE |
| Use of | Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark[1]. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway[2]. Properties Name esculin Synonym More Synonyms Esculin Biological Activity Description Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark[1]. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway[2]. Related Catalog Research Areas >> Cancer References [1]. Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct;178(2):795-807. [2]. Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May;17(5):7395-7402. Chemical & Physical Properties Molecular Formula C15H16O9 PSA 149.82000 LogP -1.52 Index of Refraction 1.689 InChIKey XHCADAYNFIFUHF-TVKJYDDYSA-N Water Solubility MODERATELY SOLUBLE |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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