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Ecdysterone structure, CAS 5289-74-7

Ecdysterone

CAS Number5289-74-7

SynonymsCRUSTECDYSONE; 20-hydroxyecdysone; MFCD00036740; β-ecdysone; (2β,3β,5β,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one; Hydroxyecdysone; b-Ecdysone; Isoinokosterone; Commisterone; (2b,3b,5b,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one; Ecdysterone

Molecular FormulaC27H44O7

Molecular Weight480.63

Purity≥93 (HPLC)%

Density1.3±0.1 g/cm3

Boiling Point702.1±60.0 °C at 760 mmHg

Melting Point242-244 °C

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol4.1

Signal WordWarning

Cat. No.: 2A-9010273 Purity: ≥93 (HPLC)%
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Quality Control of [ 5289-74-7 ] Purity: ≥93 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number5289-74-7
Catalog No.2A-9010273
Chinese Name20-羟基蜕皮甾酮
SynonymsCRUSTECDYSONE; 20-hydroxyecdysone; MFCD00036740; β-ecdysone; (2β,3β,5β,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one; Hydroxyecdysone; b-Ecdysone; Isoinokosterone; Commisterone; (2b,3b,5b,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one; Ecdysterone
Molecular FormulaC27H44O7
Molecular Weight480.63
Purity≥93 (HPLC)
Density1.3±0.1 g/cm3
Boiling Point702.1±60.0 °C at 760 mmHg
Melting Point242-244 °C
Appearancepowder
Water Solubilityalcohol: soluble
Storage ConditionStore at room temperature, away from light, in a c
PackagingII; III
ApplicationCrustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysone derived from the dewweed Cyanotis arachnoides C.B.Clarke, which controls molting and metamorphosis of arthropods. It inhibits caspa
HTC2937290090
PubChem ID24895674
MDL NumberMFCD00036740
SMILES[H][C@]12CC[C@]3(C)[C@H](CC[C@@]3(O)C1=CC(=O)[C@]4([H])C[C@@H](O)[C@@H](O)C[C@]24C)[C@@](C)(O)[C@H](O)CCC(C)(C)O
InChI1S/C27H44O7/c1-23(2,32)9-8-22(31)26(5,33)21-7-11-27(34)16-12-18(28)17-13-19(29)20(30)14-24(17,3)15(16)6-10-25(21,27)4/h12,15,17,19-22,29-34H,6-11,13-14H2,1-5H3/t15-,17-,19+,20-,21-,22+,24+,25+,26+,27+/m0/s1
InChI KeyNKDFYOWSKOHCCO-YPVLXUMRSA-N
Beilstein/REAXYS1917578
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbols4.1
MSDSmsds/10273_1_5289_74_7.pdf
Use ofCrustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Cyanotis arachnoides C.B.Clarke which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1].Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Properties Articles63 Name 20-hydroxyecdysone Synonym More Synonyms Hydroxyecdysone Biological Activity Description Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Cyanotis arachnoides C.B.Clarke which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1].Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Autophagy >> Autophagy References [1]. Liu H, et al. E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body. Insect Biochem Mol Biol. 2014 Feb;45:30-9. [2]. Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84. Chemical & Physical Properties Molecular Formula C27H44O7 Exact Mass 480.308716 PSA 138.45000 LogP -0.53 Index of Refraction 1.597 InChIKey NKDFYOWSKOHCCO-YPVLXUMRSA-N Water Solubility alcohol: soluble Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 5-beta-Cholest-7-en-6-one, 2-beta,3-beta,14,20,22,25-hexahydroxy-, (22R)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C27-H44-O7 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : male 7 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Cytogenetic analysis MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 100 nmol/L REFERENCE : ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72. Volume(issue)/page/year: 41,183,1971 Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter Hazard Codes Xi RIDADR NONH for all modes of transport WGK Germany 2 RTECS FZ8060000 Packaging Group II; III Hazard Class 4.1 HS Code 2937290090
Transport InfoProduct Name: 20-Hydroxyecdysterone
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