CAS Number74-55-5
Synonyms(S,S)-Et,Et-FerroTANE; (+)-1,1'-BIS[(2R,4R)-2,4-DIETHYLPHOSPHONATO]FERROCENE; R,R-Et-FerroTANE; (S,S)-2,2'-(ethylenediimino)di-1-butanol; (R,R)-ET-FERROTANE(TM); (+)-1,1'-BIS((2R,4R)-2,4-DIETHYLPHOSPHOTANO)FERROCENE; (S,S)-1-[1-(DI-TERT-BUTYLPHOSPHINO)ETHYL]-2-(DIPHENYLPHOSPHINO)FERROCENE; Et-Ferrotane; Ethambutol; (S)-(+)-1-[(R)-2-(DIPHENYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE; 2,2'-(1,2-Ethanediyldiimino)di(1-butanol); JOSIPHOS SL-J002-2
Molecular FormulaC10H24O2N2
Molecular Weight204.31
Purity99.00%
Density1.0±0.1 g/cm3
Boiling Point345.3±22.0 °C at 760 mmHg
Melting Point199 - 204ºC
AppearanceWhite crystalline hygroscopic powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 74-55-5 |
| Catalog No. | 2A-9010395 |
| Chinese Name | 乙胺丁醇 |
| Synonyms | (S,S)-Et,Et-FerroTANE; (+)-1,1'-BIS[(2R,4R)-2,4-DIETHYLPHOSPHONATO]FERROCENE; R,R-Et-FerroTANE; (S,S)-2,2'-(ethylenediimino)di-1-butanol; (R,R)-ET-FERROTANE(TM); (+)-1,1'-BIS((2R,4R)-2,4-DIETHYLPHOSPHOTANO)FERROCENE; (S,S)-1-[1-(DI-TERT-BUTYLPHOSPHINO)ETHYL]-2-(DIPHENYLPHOSPHINO)FERROCENE; Et-Ferrotane; Ethambutol; (S)-(+)-1-[(R)-2-(DIPHENYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE; 2,2'-(1,2-Ethanediyldiimino)di(1-butanol); JOSIPHOS SL-J002-2 |
| Molecular Formula | C10H24O2N2 |
| Molecular Weight | 204.31 |
| Purity | 99.00 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 345.3±22.0 °C at 760 mmHg |
| Melting Point | 199 - 204ºC |
| Appearance | White crystalline hygroscopic powder |
| Storage Condition | 2-8℃ |
| Application | Ethambutol is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. |
| HTC | 2922191000 |
| MDL Number | MFCD00866809 |
| SMILES | CCC(CO)NCCNC(CC)CO |
| InChI | InChI=1S/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3/t9-,10-/m0/s1 |
| InChI Key | AEUTYOVWOVBAKS-UWVGGRQHSA-N |
| MSDS | msds/10395_1_74_55_5.pdf |
| Use of | Properties Name ethambutol Synonym More Synonyms Ethambutol Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Ethambutol. Tuberculosis (Edinb), 2008. 88(2): p. 102-5. [2]. Rastogi, N., V. Labrousse, and K.S. Goh, In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain [3]. Kaur, D. and G.K. Khuller, In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents, 2001. 17(1): p. 51-5. Chemical & Physical Properties Molecular Formula C10H24N2O2 Exact Mass 204.183777 PSA 64.52000 LogP -0.05 Index of Refraction 1.478 InChIKey AEUTYOVWOVBAKS-UWVGGRQHSA-N SMILES CCC(CO)NCCNC(CC)CO Storage condition 2-8℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (R)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C10-H24-N2-O2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : Q1Y2&M2MY2&1Q -D HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Liver - jaundice, cholestatic REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,866,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - changes in motor activity (specific assay) Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,1105,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Skin and Appendages - dermatitis, other (after systemic exposure) Immunological Including Allergic - anaphylaxis REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,1105,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 23,463,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 23,463,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 23,463,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63(3),114S,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63(3),114S,1967 Safety Information HS Code 2922191000 Synthetic Route (2S,2'S)-(ethyl... CAS#:288402-24-4 Ethambutol CAS#:74-55-5 Literature: Journal of the American Chemical Society, , vol. 122, # 25 p. 5968 - 5976 (2S,2'S)-(oxala... CAS#:288402-23-3 Ethambutol CAS#:74-55-5 Literature: Journal of the American Chemical Society, , vol. 122, # 25 p. 5968 - 5976 N,N'-bis[(2S)-1... CAS#:909567-52-8 Ethambutol CAS#:74-55-5 Literature: Kotkar, Shriram P.; Sudalai, Arumugam Tetrahedron Asymmetry, 2006 , vol. 17, # 11 p. 1738 - 1742 Precursor & DownStream Precursor 9 CAS#:288402-24-4 (2S,2'S)-(ethyl... CAS#:288402-23-3 (2S,2'S)-(oxala... CAS#:909567-52-8 N,N'-bis[(2S)-1... CAS#:61051-11-4 (-)-(S)-N,N'-Bi... DownStream 1 CAS#:107-15-3 1,2-Ethanediamine |
| Transport Info | Product Name: Ethambutol |
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