CAS Number107868-30-4
SynonymsExemestan; 6-Methylenandrosta-1,4-diene-3,17-dione; 6-methylenandrost-1,4-diene-3,17-dione; Aromasin; Exemestane; androsta-1,4-diene-6-methylene-3,17-dione; Exemestance; 6-Methylene-androsta-1,4-diene-3,17-dione; MFCD00866994; 6-Methyleneandrosta-1,4-diene-3,17-dione; EXALAMIDE; 6-methylideneandrosta-1,4-diene-3,17-dione
Molecular FormulaC20H24O2
Molecular Weight296.403
Purity98%
Density1.1±0.1 g/cm3
Boiling Point453.7±45.0 °C at 760 mmHg
Melting Point155.13°C
AppearanceWhite to light yellow crystal powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 107868-30-4 |
| Catalog No. | 2A-9010439 |
| Chinese Name | 依西美坦 |
| Synonyms | Exemestan; 6-Methylenandrosta-1,4-diene-3,17-dione; 6-methylenandrost-1,4-diene-3,17-dione; Aromasin; Exemestane; androsta-1,4-diene-6-methylene-3,17-dione; Exemestance; 6-Methylene-androsta-1,4-diene-3,17-dione; MFCD00866994; 6-Methyleneandrosta-1,4-diene-3,17-dione; EXALAMIDE; 6-methylideneandrosta-1,4-diene-3,17-dione |
| Molecular Formula | C20H24O2 |
| Molecular Weight | 296.403 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 453.7±45.0 °C at 760 mmHg |
| Melting Point | 155.13°C |
| Appearance | White to light yellow crystal powder |
| Storage Condition | Sealed and stored in a cool, dry warehouse. |
| Packaging | III |
| Application | Exemestane (FCE 24304) is an aromatase inhibitor that can inhibit human placenta and mouse ovary aromatase, with IC50 of 30 nM and 40 nM respectively. |
| HTC | 2937900090 |
| SMILES | C=C1CC2C(CCC3(C)C(=O)CCC23)C2(C)C=CC(=O)C=C12 |
| InChI | InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1 |
| InChI Key | BFYIZQONLCFLEV-DAELLWKTSA-N |
| Hazard Symbols | 8 |
| Use of | Properties Articles67 Name exemestane Synonym More Synonyms Exemestane Biological Activity Related Catalog Signaling Pathways >> Others >> Aromatase Research Areas >> Cancer References [1]. Di Salle, E., et al., Novel aromatase and 5 alpha-reductase inhibitors. J Steroid Biochem Mol Biol, 1994. 49(4-6): p. 289-94. [2]. Miki, Y., et al., Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone, 2007. 40(4): p. 876-87. [3]. Wang, X. and S. Chen, Aromatase destabilizer: novel action of exemestane, a food and drug administration-approved aromatase inhibitor. Cancer Res, 2006. 66(21): p. 10281-6. [4]. Goss, P.E., et al., Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ovariectomized rats. Clin Cancer Res, 2004. 10(17): p. 5717-23. [5]. Zaccheo, T., D. Giudici, and E. Di Salle, Inhibitory effect of combined treatment with the aromatase inhibitor exemestane and tamoxifen on DMBA-induced mammary tumors in rats. J Steroid Biochem Mol Biol, 1993. 44(4-6): p. 677-80. Chemical & Physical Properties Molecular Formula C20H24O2 Exact Mass 296.177643 PSA 34.14000 Index of Refraction 1.572 InChIKey BFYIZQONLCFLEV-DAELLWKTSA-N Safety Information GHS07, GHS08 Signal Word Danger Hazard Statements H319-H360 Precautionary Statements P201-P305 + P351 + P338-P308 + P313 Hazard Codes T,N Risk Phrases 60-61-51 WGK Germany 3 Packaging Group III Hazard Class 8 HS Code 2937900090 Synthetic Route 6-Methyleneandr... CAS#:19457-55-7 Exemestane CAS#:107868-30-4 Literature: Crystal Pharma, S.A. Patent: EP2070943 A1, 2009 ; Location in patent: Page/Page column 9 ; CAS#:933455-74-4 Exemestane CAS#:107868-30-4 ((8R,9S,10R,13S... CAS#:861395-77-9 Exemestane CAS#:107868-30-4 Precursor & DownStream Precursor 9 CAS#:19457-55-7 6-Methyleneandr... CAS#:861395-77-9 ((8R,9S,10R,13S... CAS#:122370-91-6 Methylene boldenone CAS#:7440-44-0 DownStream 1 CAS#:184972-12-1 (8R,9S,10R,13S,... |
| Tax Rebate | 9.0% |
| Supervision | Q. Customs clearance form for imported drugs |
| Transport Info | Product name: Supervision conditions Q. Customs clearance form for imported drugs |
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