CAS Number128196-01-0
SynonymsMFCD06407826; UNII-4O4S742ANY; Escitalopram; (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile; Seroplex; Citalopram; (+)-Citalopram; Lexapro; (S)-citalopram; S(+)-citalopram; Cipralex; S-(+)-Citalopram; (1S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
Molecular FormulaC20H21O1N2F1
Molecular Weight324.4
Purity98%
Density1.2±0.1 g/cm3
Boiling Point428.3±45.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 128196-01-0 |
| Catalog No. | 2A-0202054 |
| Chinese Name | 艾司西酞普兰 |
| Synonyms | MFCD06407826; UNII-4O4S742ANY; Escitalopram; (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile; Seroplex; Citalopram; (+)-Citalopram; Lexapro; (S)-citalopram; S(+)-citalopram; Cipralex; S-(+)-Citalopram; (1S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile |
| Molecular Formula | C20H21O1N2F1 |
| Molecular Weight | 324.4 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 428.3±45.0 °C at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. |
| HTC | 2932999099 |
| MDL Number | MFCD09817397 |
| SMILES | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 |
| InChI | InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1 |
| InChI Key | WSEQXVZVJXJVFP-FQEVSTJZSA-N |
| MSDS | msds/10377_1_128196_01_0.pdf |
| Use of | Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.Target: SSRIsEscitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase. Properties Name escitalopram Synonym More Synonyms Escitalopram Biological Activity Description Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.Target: SSRIsEscitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase. Related Catalog Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter Research Areas >> Neurological Disease Natural Products >> Others Human Endogenous Metabolite References [1]. Zhang, P., et al., Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbon itrile) analogues at monoamine transporters. J Med Chem, 2010. 53(16): p. 6112-21. [2]. Pastoor, D. and J. Gobburu, Clinical pharmacology review of escitalopram for the treatment of depression. Expert Opin Drug Metab Toxicol, 2014. 10(1): p. 121-8. Chemical & Physical Properties Molecular Formula C20H21FN2O PSA 110.86000 Index of Refraction 1.591 InChIKey WSEQXVZVJXJVFP-FQEVSTJZSA-N Storage condition 2-8℃ Safety Information HS Code 2932999099 Synthetic Route (S)-(+)-3-(5-br... 488148-14-7 Escitalopram 128196-01-0 488787-59-3 Escitalopram 128196-01-0 (S)-{3-[5-iodo-... 878655-30-2 Copper cyanide Escitalopram 128196-01-0 Precursor & DownStream Precursor 9 CAS#:488787-59-3 CAS#:878655-30-2 (S)-{3-[5-iodo-... CAS#:544-92-3 Copper cyanide CAS#:50-00-0 Formaldehyde DownStream 4 CAS#:817203-55-7 (S)-1-(3-chloro... CAS#:144025-14-9 (S)-Desmethylci... CAS#:219861-08-2 Escitalopram oxalate CAS#:766508-94-5 (S)-Didemethyla... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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