CAS Number50-27-1
Synonyms16α-Estriol; OVESTIN; TRIOVEX; (16a,17b)-Estra-1,3,5(10)-triene-3,16,17-triol; 16a-Hydroxyestradiol; Tridestrin; Oestriol; Thulol; Ovo-Vinces; Colpogyn; Orestin; MFCD00003691; oekolp; Theelol; E 3; Estriol; 16α,17β-Estriol; OE3; (16α,17β)-Oestra-1,3,5(10)-triene-3,16,17-triol; 16α-Hydroxyestradiol; Aacifemine; Holin; Ortho-Gynest; 16a-Estriol; Estratriol; Estra-1,3,5(10)-triene-3,16α,17β-triol; Gynasan; Klimax E; trans-Estriol; Estra-1,3,5(10)-triene-3,16a,17b-triol
Molecular FormulaC18H24O3
Molecular Weight288.38
Purity98%
Density1.3±0.1 g/cm3
Boiling Point469.0±45.0 °C at 760 mmHg
Melting Point280-282 °C (lit.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 50-27-1 |
| Catalog No. | 2A-9010388 |
| Chinese Name | 雌三醇 |
| Synonyms | 16α-Estriol; OVESTIN; TRIOVEX; (16a,17b)-Estra-1,3,5(10)-triene-3,16,17-triol; 16a-Hydroxyestradiol; Tridestrin; Oestriol; Thulol; Ovo-Vinces; Colpogyn; Orestin; MFCD00003691; oekolp; Theelol; E 3; Estriol; 16α,17β-Estriol; OE3; (16α,17β)-Oestra-1,3,5(10)-triene-3,16,17-triol; 16α-Hydroxyestradiol; Aacifemine; Holin; Ortho-Gynest; 16a-Estriol; Estratriol; Estra-1,3,5(10)-triene-3,16α,17β-triol; Gynasan; Klimax E; trans-Estriol; Estra-1,3,5(10)-triene-3,16a,17b-triol |
| Molecular Formula | C18H24O3 |
| Molecular Weight | 288.38 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 469.0±45.0 °C at 760 mmHg |
| Melting Point | 280-282 °C (lit.) |
| Appearance | powder |
| Water Solubility | Water solubility: insoluble; soluble in: methanol; |
| Storage Condition | This product is sealed and stored in a dry place a |
| Application | Estriol is a G protein-coupled estrogen receptor antagonist that can act on estrogen receptor-negative breast cancer cells. |
| MDL Number | MFCD00003691 |
| SMILES | C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@@H](O)[C@@H]2O |
| InChI | 1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1 |
| InChI Key | PROQIPRRNZUXQM-ZXXIGWHRSA-N |
| Beilstein/REAXYS | 2508172 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1 |
| MSDS | msds/10388_1_50_27_1.pdf |
| Bioactivity | Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.Target: Estrogen Receptor/ERRA recent study shows that estrogen (estrone, estradiol, and estriol) inhibits Alzheimer's disease-associated low-order Aβ oligomer formation, and among them, estriol shows the strongest in vitro activity [1]. In mPTEN± mice, estriol treatments resulted in a 187.54% gain in the relative ratio of uterine wet weight to body weight; estriol also increases the ratio to 176.88% in wild-type mice [2]. Estriol treatment (20 mg/kg ip), in vivo, sensitizes Kupffer cells to LPS via mechanisms dependent on an increase in CD14 by elevated portal blood endotoxin caused by increased gut permeability in rats; while one-half of the rats given estriol intraperitoneally 24 hours before an injection of a sublethal dose of LPS (5 mg/kg) died within 24 hours [3]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Natural Products >> Others Research Areas >> Cancer Target Human Endogenous Metabolite References [1]. Morinaga, A., et al., Effects of sex hormones on Alzheimer's disease-associated beta-amyloid oligomer formation in vitro. Exp Neurol, 2011. 228(2): p. 298-302. [2]. Begum, M., et al., Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice. Lab Invest, 2006. 86(3): p. 286-96. [3]. Hewitt, S.C. and K.S. Korach, Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles. Environ Health Perspect, 2011. 119(1): p. 63-70. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 469.0±45.0 °C at 760 mmHg Melting Point 280-282 °C(lit.) Molecular Formula C18H24O3 Molecular Weight 288.381 Flash Point 220.8±23.3 °C Exact Mass 288.172546 PSA 60.69000 LogP 2.94 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.624 InChIKey PROQIPRRNZUXQM-ZXXIGWHRSA-N SMILES CC12CCC3c4ccc(O)cc4CCC3C1CC(O)C2O Storage condition -20°C Freezer |
| Use of | Properties Articles131 Name estriol Synonym More Synonyms Estriol Biological Activity Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Natural Products >> Others Research Areas >> Cancer Human Endogenous Metabolite References [1]. Morinaga, A., et al., Effects of sex hormones on Alzheimer's disease-associated beta-amyloid oligomer formation in vitro. Exp Neurol, 2011. 228(2): p. 298-302. [2]. Begum, M., et al., Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice. Lab Invest, 2006. 86(3): p. 286-96. [3]. Hewitt, S.C. and K.S. Korach, Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles. Environ Health Perspect, 2011. 119(1): p. 63-70. Chemical & Physical Properties Molecular Formula C18H24O3 Exact Mass 288.172546 PSA 60.69000 Index of Refraction 1.624 InChIKey PROQIPRRNZUXQM-ZXXIGWHRSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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