CAS Number50-41-9
SynonymsClomiphene-R; Clomiphene (citrate); CLOMID; 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine,Clomiphene citrate salt; Fertyl; clomiphen citrate; mrl41; MFCD00058322; clomivid; CLOMPHID; Clomiphene citrate salt; Pergotime; dyneric; EINECS 200-035-3; 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine citrate; genozym; Clomifene citrate; 2-(p-(2-Chloro-1,2-diphenylvinyl)phenoxy)triethylamine citrate (1:1); mer41; Fertivet; omifin
Molecular FormulaC32H36ClNO8
Molecular Weight598.08
Purity98%
Boiling Point509ºC at 760 mmHg
Melting Point116.5-118°C
Appearancecrystalline solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 50-41-9 |
| Catalog No. | 2A-9009860 |
| Chinese Name | 克罗米酚柠檬酸盐 |
| Synonyms | Clomiphene-R; Clomiphene (citrate); CLOMID; 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine,Clomiphene citrate salt; Fertyl; clomiphen citrate; mrl41; MFCD00058322; clomivid; CLOMPHID; Clomiphene citrate salt; Pergotime; dyneric; EINECS 200-035-3; 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine citrate; genozym; Clomifene citrate; 2-(p-(2-Chloro-1,2-diphenylvinyl)phenoxy)triethylamine citrate (1:1); mer41; Fertivet; omifin |
| Molecular Formula | C32H36ClNO8 |
| Molecular Weight | 598.08 |
| Purity | 98 |
| Boiling Point | 509ºC at 760 mmHg |
| Melting Point | 116.5-118°C |
| Appearance | crystalline solid |
| Storage Condition | Seal and store in a dry place at 4°C away from lig |
| Application | Clomifene citrate is an estrogen receptor modulator. |
| PubChem ID | 329749429 |
| MDL Number | MFCD00058322 |
| SMILES | OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)CCOc1ccc(cc1)\C(=C(\Cl)c2ccccc2)c3ccccc3 |
| InChI | 1S/C26H28ClNO.C6H8O7/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,3-4,19-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25+; |
| InChI Key | PYTMYKVIJXPNBD-BTKVJIOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/9860_1_50_41_9.pdf |
| Bioactivity | Clomifene Citrate is a selective estrogen receptor modulator.Target: Estrogen Receptor/ERRClomifene Citrate(CC) acted as an estrogen antagonist regardless of the concentration of E2 added together. In conclusion, CC acts as an estrogen agonist/antagonist via ER alpha in a coexisting estrogen concentration-dependent way whereas it acts as an estrogen antagonist via ER beta whether or not estrogen is present [1]. Clomiphene was effective in increasing pregnancy rate compared to placebo (OR 5.8, 95% CI 1.6 to 21.5) as was clomiphene plus dexamethasone treatment (OR 9.46, 95% CI 5.1 to 17.7) compared to clomiphene alone. A significant improvement in the pregnancy rate was reported for clomiphene plus combined oral contraceptives versus clomiphene alone. No evidence of a difference in effect on pregnancy rate was found with any of the other comparisons [2]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology References [1]. Kurosawa, T., et al., Clomiphene citrate elicits estrogen agonistic/antagonistic effects differentially via estrogen receptors alpha and beta. Endocr J, 2010. 57(6): p. 517-21. [2]. Brown, J., et al., Clomiphene and anti-oestrogens for ovulation induction in PCOS. Cochrane Database Syst Rev, 2009(4): p. CD002249. Chemical & Physical Properties Boiling Point 509ºC at 760 mmHg Melting Point 116.5-118°C Molecular Formula C32H36ClNO8 Molecular Weight 598.083 Flash Point 261.6ºC Exact Mass 597.212952 PSA 144.60000 LogP 5.31410 InChIKey PYTMYKVIJXPNBD-UHFFFAOYSA-N SMILES CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1.O=C(O)CC(O)(CC(=O)O)C(=O)O Storage condition 2-8°C |
| Use of | Clomifene Citrate is a selective estrogen receptor modulator.Target: Estrogen Receptor/ERRClomifene Citrate(CC) acted as an estrogen antagonist regardless of the concentration of E2 added together. In conclusion, CC acts as an estrogen agonist/antagonist via ER alpha in a coexisting estrogen concentration-dependent way whereas it acts as an estrogen antagonist via ER beta whether or not estrogen is present [1]. Clomiphene was effective in increasing pregnancy rate compared to placebo (OR 5.8, 95% CI 1.6 to 21.5) as was clomiphene plus dexamethasone treatment (OR 9.46, 95% CI 5.1 to 17.7) compared to clomiphene alone. A significant improvement in the pregnancy rate was reported for clomiphene plus combined oral contraceptives versus clomiphene alone. No evidence of a difference in effect on pregnancy rate was found with any of the other comparisons [2]. Properties Articles25 Name Clomiphene Citrate Synonym More Synonyms Clomiphene Citrate Biological Activity Description Clomifene Citrate is a selective estrogen receptor modulator.Target: Estrogen Receptor/ERRClomifene Citrate(CC) acted as an estrogen antagonist regardless of the concentration of E2 added together. In conclusion, CC acts as an estrogen agonist/antagonist via ER alpha in a coexisting estrogen concentration-dependent way whereas it acts as an estrogen antagonist via ER beta whether or not estrogen is present [1]. Clomiphene was effective in increasing pregnancy rate compared to placebo (OR 5.8, 95% CI 1.6 to 21.5) as was clomiphene plus dexamethasone treatment (OR 9.46, 95% CI 5.1 to 17.7) compared to clomiphene alone. A significant improvement in the pregnancy rate was reported for clomiphene plus combined oral contraceptives versus clomiphene alone. No evidence of a difference in effect on pregnancy rate was found with any of the other comparisons [2]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology References [1]. Kurosawa, T., et al., Clomiphene citrate elicits estrogen agonistic/antagonistic effects differentially via estrogen receptors alpha and beta. Endocr J, 2010. 57(6): p. 517-21. [2]. Brown, J., et al., Clomiphene and anti-oestrogens for ovulation induction in PCOS. Cochrane Database Syst Rev, 2009(4): p. CD002249. Chemical & Physical Properties Exact Mass 597.212952 PSA 144.60000 LogP 5.31410 InChIKey PYTMYKVIJXPNBD-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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