CAS Number671-95-4
SynonymsFrictan; Eleklin; 4-chloro-benzene-1,3-disulfonic acid diamide; Aponiere; Indigatin; 4-Chlor-benzol-1,3-disulfonamid; Haflutan; Monochlorphenamide; 4-Chlor-benzol-1,3-disulfonsaeure-diamid; Diumide; 1-Chlor-2,4-bis-sulfamoyl-benzol; Clofenamide; Mahi; 4-chloro-benzene-1,3-disulfonamide; Aquedux
Molecular FormulaC6H7ClN2O4S2
Molecular Weight270.715
Purity98.00%
Density1.699g/cm3
Boiling Point551.6ºC at 760 mmHg
Melting Point206-207° (Davies); mp 217-219° (Olivier)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 671-95-4 |
| Catalog No. | 2A-9009855 |
| Chinese Name | 氯非那胺 |
| Synonyms | Frictan; Eleklin; 4-chloro-benzene-1,3-disulfonic acid diamide; Aponiere; Indigatin; 4-Chlor-benzol-1,3-disulfonamid; Haflutan; Monochlorphenamide; 4-Chlor-benzol-1,3-disulfonsaeure-diamid; Diumide; 1-Chlor-2,4-bis-sulfamoyl-benzol; Clofenamide; Mahi; 4-chloro-benzene-1,3-disulfonamide; Aquedux |
| Molecular Formula | C6H7ClN2O4S2 |
| Molecular Weight | 270.715 |
| Purity | 98.00 |
| Density | 1.699g/cm3 |
| Boiling Point | 551.6ºC at 760 mmHg |
| Melting Point | 206-207° (Davies); mp 217-219° (Olivier) |
| Application | Chlofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Chlofenamide has diuretic effects [1]. |
| HTC | 2935009090 |
| MDL Number | MFCD00210257 |
| SMILES | NS(=O)(=O)c1ccc(Cl)c(S(N)(=O)=O)c1 |
| InChI | InChI=1S/C6H7ClN2O4S2/c7-5-2-1-4(14(8,10)11)3-6(5)15(9,12)13/h1-3H,(H2,8,10,11)(H2,9,12,13) |
| InChI Key | NENBAISIHCWPKP-UHFFFAOYSA-N |
| MSDS | msds/9855_1_671_95_4.pdf |
| Use of | Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity[1]. Properties Name 4-chlorobenzene-1,3-disulfonamide Synonym More Synonyms clofenamide Biological Activity Description Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity[1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Metabolic Disease References [1]. Delbeke FT, et, al. The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine. Arzneimittelforschung. 1986 Sep;36(9):1413-6. Chemical & Physical Properties Exact Mass 269.95400 PSA 137.08000 LogP 3.19700 Index of Refraction 1.627 InChIKey NENBAISIHCWPKP-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : m-Benzenedisulfonamide, 4-chloro- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C6-H7-Cl-N2-O4-S2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : ZSWR BG ESZW HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979 Safety Information HS Code 2935009090 Synthetic Route Total: 1 Page 4-chlorobenzene... CAS#:2891-17-0 clofenamide CAS#:671-95-4 Literature: Bollettino Chimico Farmaceutico, , vol. 97, p. 451 Precursor & DownStream Precursor 1 CAS#:2891-17-0 4-chlorobenzene... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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