CAS Number10596-23-3
SynonymsClodronic Acid; methanedichlorodiphosphonic acid; Acide clodronique; Acidum clodronicum; Bonefos; Acido clodronico; Clodronsaeure; Dichloromethylidene diphosphonate; (dichloromethylene)bisphosphonic acid; [dichloro(phosphono)methyl]phosphonic acid; Dichloromethanediphosphonic acid; EINECS 234-212-1; dichloromethanediphosphonate; dichloro-methylene diphosphonate; (dichloromethanediyl)bis(phosphonic acid); (Dichloromethylene)bis(phosphonic acid); P,P'-(Dichloromethylene)Bis-Phosphonic Acid; Clodronate; dichloromethylenediphosphonic acid; Clodronate disodium
Molecular FormulaCH2O6Cl2Na2P2
Molecular Weight288.86
Purity98%
Density2.3±0.1 g/cm3
Boiling Point474.7±55.0 °C at 760 mmHg
Melting Point249-251°
Appearancepowder
EINECS245-078-9
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 10596-23-3 |
| Catalog No. | 2A-9009853 |
| Chinese Name | 氯屈瞵酸 |
| Synonyms | Clodronic Acid; methanedichlorodiphosphonic acid; Acide clodronique; Acidum clodronicum; Bonefos; Acido clodronico; Clodronsaeure; Dichloromethylidene diphosphonate; (dichloromethylene)bisphosphonic acid; [dichloro(phosphono)methyl]phosphonic acid; Dichloromethanediphosphonic acid; EINECS 234-212-1; dichloromethanediphosphonate; dichloro-methylene diphosphonate; (dichloromethanediyl)bis(phosphonic acid); (Dichloromethylene)bis(phosphonic acid); P,P'-(Dichloromethylene)Bis-Phosphonic Acid; Clodronate; dichloromethylenediphosphonic acid; Clodronate disodium |
| Molecular Formula | CH2O6Cl2Na2P2 |
| Molecular Weight | 288.86 |
| Purity | 98 |
| Density | 2.3±0.1 g/cm3 |
| Boiling Point | 474.7±55.0 °C at 760 mmHg |
| Melting Point | 249-251° |
| Appearance | powder |
| Storage Condition | 2-8°C, store in inert gas |
| Application | Clodronate is an orally active bisphosphonate used in the study of osteoporosis and diseases related to excessive bone resorption. Clodronate inhibits bone resorption by inducing osteoclast apoptosis. |
| EINECS | 245-078-9 |
| HTC | 2931900090 |
| PubChem ID | 24278371 |
| MDL Number | MFCD01632786 |
| SMILES | [Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O |
| InChI | 1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2 |
| InChI Key | HJKBJIYDJLVSAO-UHFFFAOYSA-L |
| NACRES Code | NA.77 |
| UNSPSC | 12352106 |
| MSDS | msds/9853_1_10596_23_3.pdf |
| Use of | Clodronic acid is an orally active bisphosphonate, which is used for researching osteoporosis and diseases associated with excessive bone resorption. Clodronic acid inhibits bone resorption through induction of osteoclast apoptosis. Clodronic acid is effective in the maintenance or improvement of bone mineral density[1]. Properties Name clodronic acid Synonym More Synonyms Clodronic Acid Biological Activity Description Clodronic acid is an orally active bisphosphonate, which is used for researching osteoporosis and diseases associated with excessive bone resorption. Clodronic acid inhibits bone resorption through induction of osteoclast apoptosis. Clodronic acid is effective in the maintenance or improvement of bone mineral density[1]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Frediani B, et al. Clodronic acid formulations available in Europe and their use in osteoporosis: a review. Clin Drug Investig. 2009;29(6):359-79. Chemical & Physical Properties Exact Mass 243.886017 PSA 134.68000 LogP -2.38 Index of Refraction 1.598 InChIKey ACSIXWWBWUQEHA-UHFFFAOYSA-N SMILES O=P(O)(O)C(Cl)(Cl)P(=O)(O)O Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Phosphonic acid, (dichloromethylene)bis- CAS REGISTRY NUMBER : 10596-23-3 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C-H4-Cl2-O6-P2 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in iron REFERENCE : Safety Information HS Code 2931900090 |
| Tax Rebate | 13.0% |
| Supervision | AB (Inbound cargo customs clearance form) |
| Transport Info | Product name: Chlorotrionic acid |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Clobutinol | 14860-49-2 | 2A-9009848 |
| Clocanfamide | 18966-32-0 | 2A-9009849 |
| Clocortolone | 4828-27-7 | 2A-9009850 |
| Clodoxopone | 71923-34-7 | 2A-9009851 |
| Clodronate disodium | 88416-50-6 | 2A-9009852 |
| Clofarabine | 123318-82-1 | 2A-9009854 |
| Clofenamide | 671-95-4 | 2A-9009855 |
| Clofenotane | 50-29-3 | 2A-9009856 |
| Clofibride | 26717-47-5 | 2A-9009858 |
| Clofilium phosphate | 68379-03-3 | 2A-9009859 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS