CAS Number26717-47-5
SynonymsButyramide,N-dimethyl-4-(p-chlorophenoxyisobutyrate); Clofibride; Clofibrida [INN-Spanish]; N-Dimethyl-4-(p-chlorophenoxyisobutyrate)butyramide; MG 46; EINECS 247-912-7; Lipenan; 3-dimethylcarbamoylpropyl 2-(4-chlorophenoxy)-2-methylpropionate; Clofibridum [INN-Latin]
Molecular FormulaC16H22ClNO4
Molecular Weight327.80300
Purity98.00%
Density1.163g/cm3
Boiling Point448.7ºC at 760mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 26717-47-5 |
| Catalog No. | 2A-9009858 |
| Chinese Name | 氯贝胺 |
| Synonyms | Butyramide,N-dimethyl-4-(p-chlorophenoxyisobutyrate); Clofibride; Clofibrida [INN-Spanish]; N-Dimethyl-4-(p-chlorophenoxyisobutyrate)butyramide; MG 46; EINECS 247-912-7; Lipenan; 3-dimethylcarbamoylpropyl 2-(4-chlorophenoxy)-2-methylpropionate; Clofibridum [INN-Latin] |
| Molecular Formula | C16H22ClNO4 |
| Molecular Weight | 327.80300 |
| Purity | 98.00 |
| Density | 1.163g/cm3 |
| Boiling Point | 448.7ºC at 760mmHg |
| Application | Chlorofibril is an orally active polychlorophenoxyisobutyl hypolipidemic agent. Chlorofibrils have weak toxicity and significant hypocholesterolemic and hypoglyceremic activity. Chlorofibrils are conv |
| HTC | 2924299090 |
| SMILES | CN(C)C(=O)CCCOC(=O)C(C)(C)Oc1ccc(Cl)cc1 |
| InChI | InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3 |
| InChI Key | CXQGFLBVUNUQIA-UHFFFAOYSA-N |
| Use of | Clofibride is an orally active hypolipaemic agent of pchlorophenoxyisobutyric type. Clofibride has weak toxicity and marked hypocholesterolaemic and hypotriglyceridaemic activity. Clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) in vivo[1]. Properties Name [4-(dimethylamino)-4-oxobutyl] 2-(4-chlorophenoxy)-2-methylpropanoate Synonym More Synonyms clofibride Biological Activity Description Clofibride is an orally active hypolipaemic agent of pchlorophenoxyisobutyric type. Clofibride has weak toxicity and marked hypocholesterolaemic and hypotriglyceridaemic activity. Clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) in vivo[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Chemical & Physical Properties Exact Mass 327.12400 PSA 55.84000 LogP 2.90900 Index of Refraction 1.515 InChIKey CXQGFLBVUNUQIA-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ester with 4-hydroxy-N,N-dimethylbutyramide CAS REGISTRY NUMBER : 26717-47-5 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C16-H22-Cl-N-O4 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : GR DOX1&1&VO3VN1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : male 7 day(s) pre-mating female 7 day(s) pre-mating female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth REFERENCE : JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 Safety Information HS Code 2924299090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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