CAS Number30299-08-2
Synonyms2-[4-[1-[4-(2-carboxybutan-2-yloxy)phenyl]cyclohexyl]phenoxy]-2-methylbutanoic acid; 2,2'-[1,1-Cyclohexanediylbis(4,1-phenyleneoxy)]bis(2-methylbutanoic acid); 2,2'-[cyclohexane-1,1-diylbis(benzene-4,1-diyloxy)]bis(2-methylbutanoic acid); 2,2'-[Cyclohexane-1,1-diylbis(4,1-phenyleneoxy)]bis(2-methylbutanoic acid); MFCD00865769
Molecular FormulaC28H36O6
Molecular Weight468.596
Purity98%
Density1.2±0.1 g/cm3
Boiling Point613.8±55.0 °C at 760 mmHg
Melting Point143-145°C
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 30299-08-2 |
| Catalog No. | 2A-9009840 |
| Chinese Name | 克利贝特 |
| Synonyms | 2-[4-[1-[4-(2-carboxybutan-2-yloxy)phenyl]cyclohexyl]phenoxy]-2-methylbutanoic acid; 2,2'-[1,1-Cyclohexanediylbis(4,1-phenyleneoxy)]bis(2-methylbutanoic acid); 2,2'-[cyclohexane-1,1-diylbis(benzene-4,1-diyloxy)]bis(2-methylbutanoic acid); 2,2'-[Cyclohexane-1,1-diylbis(4,1-phenyleneoxy)]bis(2-methylbutanoic acid); MFCD00865769 |
| Molecular Formula | C28H36O6 |
| Molecular Weight | 468.596 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 613.8±55.0 °C at 760 mmHg |
| Melting Point | 143-145°C |
| Storage Condition | Refrigerator |
| Application | Clinofibrate (S-8527) is a hypolipidemic agent and an HMG-CoA reductase inhibitor. |
| MDL Number | MFCD00865769 |
| SMILES | CCC(C)(Oc1ccc(C2(c3ccc(OC(C)(CC)C(=O)O)cc3)CCCCC2)cc1)C(=O)O |
| InChI | InChI=1S/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32) |
| InChI Key | BMOVQUBVGICXQN-UHFFFAOYSA-N |
| MSDS | msds/9840_1_30299_08_2.pdf |
| Bioactivity | Clinofibrate (S-8527) is a hypelipidemic agent and a HMG-CoA reductase inhibitor. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Metabolic Disease In Vivo Clinofibrate administration (50 and 100 mg/kg/day, p.o.) significantly inhibits the increase in plasma fibrinogen level as well as serum- and VLDL-LDL-lipids[1]. Clinofibrate significantly decreases the high plasma cholesterol level of atherosclerotic rats, which is 823±256 mg/dl, or about ten times that of control rats (85±11 mg/dl). On treatment with clinofibrate, the cholesterol level is reduced most in the very low density lipoprotein (VLDL) fraction[2]. In rats which are refed either a fat-free diet or a 5% fat diet after a 2-day fast. clinofibrate at 30 mg/kg results in reductions of serum and liver triglyceride levels[3]. Oral ingestion of S-8527 to normal rats for 7 days lowers serum triglycerides and cholesterol by about 27% at 1 mg/kg and 20% at 3 mg/kg, respectively. S-8527 at 3 mg/kg decreases liver triglyceride concentration by about 20%[4]. Animal Admin Rats: Male Wistar rats weighing 100-160 g are used. S-8527 and clofibrate are suspended in an appropriate amount of 5 gum arabic solution so that the daily dose would be 0.5 mL per 100 g of body weight. The drugs are given to the rats via stomach tube every a.m. for 7 days. Control groups are on an equal volume of vehicle. During the experimental period, the animals are fed on a commercial chow pellet ad libitum. About 24 hr after the last dose, the rats are anesthetized with ether and blood samples are obtained from the inferior venacava. After sacrifice, the livers are removed, washed with physiological saline, blotted on filter paper and weighed[4]. References [1]. Okazaki M, et al. Effects of clinofibrate on plasma fibrinogen level in high fructose diet-induced hyperlipidemic rats. In Vivo. 1994 Nov-Dec;8(6):1057-61. [2]. Shirai K, et al. Effect of clinofibrate on lipid metabolism of aorta in atherosclerotic rats. Artery. 1983;12(3):145-55. [3]. Suzuki K, et al. Effects of S-8527 (1,1-bis4'-(1"-carboxy'1"-methylpropoxy)-phenyl)-cyclohexane), a new hypolipidemic compound, on triglyceride metablolism in rats. Biochem Pharmacol. 1975 Jun 15;24(11-12):1203-7. [4]. Suzuki K, et al. Hypolipidemic effect of a new aryloxy compound, S-8527, in experimental animals. Jpn J Pharmacol. 1974 Jun;24(3):407-14. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 613.8±55.0 °C at 760 mmHg Melting Point 143-145°C Molecular Formula C28H36O6 Molecular Weight 468.582 Flash Point 198.1±25.0 °C Exact Mass 468.251190 PSA 93.06000 LogP 6.71 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.559 InChIKey BMOVQUBVGICXQN-UHFFFAOYSA-N SMILES CCC(C)(Oc1ccc(C2(c3ccc(OC(C)(CC)C(=O)O)cc3)CCCCC2)cc1)C(=O)O Storage condition Refrigerator |
| Use of | Clinofibrate (S-8527) is a hypelipidemic agent and a HMG-CoA reductase inhibitor. Properties Name Clinofibrate Synonym More Synonyms Clinofibrate Biological Activity Description Clinofibrate (S-8527) is a hypelipidemic agent and a HMG-CoA reductase inhibitor. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Metabolic Disease References [1]. Okazaki M, et al. Effects of clinofibrate on plasma fibrinogen level in high fructose diet-induced hyperlipidemic rats. In Vivo. 1994 Nov-Dec;8(6):1057-61. [2]. Shirai K, et al. Effect of clinofibrate on lipid metabolism of aorta in atherosclerotic rats. Artery. 1983;12(3):145-55. [3]. Suzuki K, et al. Effects of S-8527 (1,1-bis4'-(1"-carboxy'1"-methylpropoxy)-phenyl)-cyclohexane), a new hypolipidemic compound, on triglyceride metablolism in rats. Biochem Pharmacol. 1975 Jun 15;24(11-12):1203-7. [4]. Suzuki K, et al. Hypolipidemic effect of a new aryloxy compound, S-8527, in experimental animals. Jpn J Pharmacol. 1974 Jun;24(3):407-14. Chemical & Physical Properties Molecular Formula C28H36O6 Exact Mass 468.251190 PSA 93.06000 Index of Refraction 1.559 InChIKey BMOVQUBVGICXQN-UHFFFAOYSA-N Storage condition Refrigerator |
| Transport Info | Product name: Clinofibrate |
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