CAS Number130-26-7
Synonyms5-Chloro-8-hydroxy-7-iodoquinoline; Emaform; Bactol; 5-21-03-00294 (Beilstein Handbook Reference); 5-chloro-7-iodo-8-hydroxy-quinoline; EINECS 204-984-4; Clioqinol; Vioform; cortin; T66 BNJ GG II JQ; Amebil; Rometin; MFCD00006787; 5-Chloro-7-iodo-8-quinolinol; 5-chloro-7-iodoquinolin-8-ol; oralcer; Nioform; Cliochinolo [DCIT]; Amoenol; Clioquinol; Cliquinol; hysone; 5-Cl-7-I-8-HQ; iodochlorohydroxyquinoline; iodochlorohydroxyquin; corque
Molecular FormulaC9H5ClINO
Molecular Weight305.50
Purity≥95.0 (HPLC)%
Density2.0±0.1 g/cm3
Boiling Point350.4±37.0 °C at 760 mmHg
Melting Point175-183 °C
Appearancepowder
EINECS204-984-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 130-26-7 |
| Catalog No. | 2A-9009842 |
| Chinese Name | 5-氯-8-羟基-7-碘喹啉 |
| Synonyms | 5-Chloro-8-hydroxy-7-iodoquinoline; Emaform; Bactol; 5-21-03-00294 (Beilstein Handbook Reference); 5-chloro-7-iodo-8-hydroxy-quinoline; EINECS 204-984-4; Clioqinol; Vioform; cortin; T66 BNJ GG II JQ; Amebil; Rometin; MFCD00006787; 5-Chloro-7-iodo-8-quinolinol; 5-chloro-7-iodoquinolin-8-ol; oralcer; Nioform; Cliochinolo [DCIT]; Amoenol; Clioquinol; Cliquinol; hysone; 5-Cl-7-I-8-HQ; iodochlorohydroxyquinoline; iodochlorohydroxyquin; corque |
| Molecular Formula | C9H5ClINO |
| Molecular Weight | 305.50 |
| Purity | ≥95.0 (HPLC) |
| Density | 2.0±0.1 g/cm3 |
| Boiling Point | 350.4±37.0 °C at 760 mmHg |
| Melting Point | 175-183 °C |
| Appearance | powder |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Storage Condition | The warehouse is low-temperature, ventilated, dry, |
| Packaging | III |
| Application | Clioquinol (Iodochlorhydroxyquin) is an antifungal compound that has recently been found to have anti-AD and anti-tumor activity. |
| EINECS | 204-984-4 |
| HTC | 2933499090 |
| PubChem ID | 57648095 |
| MDL Number | MFCD00006787 |
| SMILES | Oc1c(I)cc(Cl)c2cccnc12 |
| InChI | 1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H |
| InChI Key | QCDFBFJGMNKBDO-UHFFFAOYSA-N |
| Beilstein/REAXYS | 153637 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/9842_1_130_26_7.pdf |
| Bioactivity | Clioquinol(Iodochlorhydroxyquin) is an antifungal drug and antiprotozoal compound that shows effectivity for Alzheimer's disease treatment and induce cancer cell death. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Infection References [1]. Nguyen T, et al. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11840-5. [2]. Cao B, et al. Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway. Sci Rep. 2014 Jul 18;4:5749. [3]. Katsuyama M, et al. Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression. J Pharmacol Sci. 2014;124(4):427-32. [4]. Matlack KE, et al. Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4013-8. Chemical & Physical Properties Density 2.0±0.1 g/cm3 Boiling Point 350.4±37.0 °C at 760 mmHg Melting Point 175-183 °C Molecular Formula C9H5ClINO Molecular Weight 305.500 Flash Point 165.7±26.5 °C Exact Mass 304.910431 PSA 33.12000 LogP 3.86 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.768 InChIKey QCDFBFJGMNKBDO-UHFFFAOYSA-N SMILES Oc1c(I)cc(Cl)c2cccnc12 Water Solubility <0.1 g/100 mL at 20 ºC |
| Use of | Clioquinol(Iodochlorhydroxyquin) is an antifungal drug and antiprotozoal compound that shows effectivity for Alzheimer's disease treatment and induce cancer cell death. Properties Articles61 Name 5-chloro-7-iodoquinolin-8-ol Synonym More Synonyms Clioquinol Biological Activity Description Clioquinol(Iodochlorhydroxyquin) is an antifungal drug and antiprotozoal compound that shows effectivity for Alzheimer's disease treatment and induce cancer cell death. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Infection References [1]. Nguyen T, et al. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11840-5. [2]. Cao B, et al. Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway. Sci Rep. 2014 Jul 18;4:5749. [3]. Katsuyama M, et al. Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression. J Pharmacol Sci. 2014;124(4):427-32. [4]. Matlack KE, et al. Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4013-8. Chemical & Physical Properties Exact Mass 304.910431 PSA 33.12000 Index of Refraction 1.768 InChIKey QCDFBFJGMNKBDO-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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