CAS Number105956-97-6
SynonymsMFCD00865120; Clinafloxacin; 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
Molecular FormulaC17H17O3N3Cl1F1
Molecular Weight365.79
Purity98%
Density1.573 g/cm3
Boiling Point592.3ºC at 760 mmHg
Melting Point253-258ºC
AppearanceWhite to light yellow crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 105956-97-6 |
| Catalog No. | 2A-9009834 |
| Chinese Name | 克林沙星 |
| Synonyms | MFCD00865120; Clinafloxacin; 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid |
| Molecular Formula | C17H17O3N3Cl1F1 |
| Molecular Weight | 365.79 |
| Purity | 98 |
| Density | 1.573 g/cm3 |
| Boiling Point | 592.3ºC at 760 mmHg |
| Melting Point | 253-258ºC |
| Appearance | White to light yellow crystalline powder |
| Storage Condition | 2-8°C |
| Application | Clinafloxacin (PD-127391) is a fluoroquinolone antibiotic. |
| HTC | 2933990090 |
| MDL Number | MFCD00865120 |
| SMILES | NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1 |
| InChI | InChI=1S/C17H17ClFN3O3/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9/h5,7-9H,1-4,6,20H2,(H,24,25) |
| InChI Key | QGPKADBNRMWEQR-UHFFFAOYSA-N |
| MSDS | msds/9834_1_105956_97_6.pdf |
| Use of | Clinafloxacin(PD-127391) is a fluoroquinolone antibiotic.Target: AntibacterialClinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections [1]. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity [2]. Clinafloxacin is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3]. Properties Articles28 Name 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Synonym More Synonyms Clinafloxacin Biological Activity Description Clinafloxacin(PD-127391) is a fluoroquinolone antibiotic.Target: AntibacterialClinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections [1]. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity [2]. Clinafloxacin is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Humphrey, G.H., et al., Pharmacokinetics of clinafloxacin enantiomers in humans. J Clin Pharmacol, 1999. 39(11): p. 1143-50. [2]. Pan, X.S. and L.M. Fisher, DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother, 1998. 42(11): p. 2810-6. [3]. Jorgensen, J.H., et al., Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother, 2000. 44(11): p. 2962-8. Chemical & Physical Properties Exact Mass 365.09400 PSA 88.56000 LogP 3.12980 Index of Refraction 1.684 InChIKey QGPKADBNRMWEQR-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H361d Precautionary Statements P281 Hazard Codes Xi Safety Phrases S26-S36 RIDADR NONH for all modes of transport RTECS VB1800600 HS Code 2933990090 Synthetic Route Total: 1 Page 8-CHLORO-1-CYCL... CAS#:101987-89-7 Clinafloxacin CAS#:105956-97-6 Literature: Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991 8-chloro-1-cycl... CAS#:105956-96-5 Clinafloxacin CAS#:105956-97-6 Literature: Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Clenpirin | 27050-41-5 | 2A-9009829 |
| Clentiazem | 96125-53-0 | 2A-9009830 |
| Cleocin | 58207-19-5 | 2A-9009831 |
| Clevidipine | 166432-28-6 | 2A-9009832 |
| Climiqualine | 55150-67-9 | 2A-9009833 |
| Clinofibrate | 30299-08-2 | 2A-9009840 |
| Clinolamide | 3207-50-9 | 2A-9009841 |
| Clioquinol | 130-26-7 | 2A-9009842 |
| Cliropamine | 109525-44-2 | 2A-9009843 |
| Clobazam | 22316-47-8 | 2A-9009844 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS