CAS Number73384-59-5
SynonymsCeftriazone; Biotrakson; Rocefin; Ceftriaxone; ceftriaxonum [INN_la]; ceftriaxome; Ceftriaxone [USAN:JAN]; Antibiotic Ro-13-9904; Cefatriaxone; MFCD00865013; EINECS 277-405-6; Rocephin
Molecular FormulaC18H18N8O7S3
Molecular Weight554.59
Purity98%
Density2.0±0.1 g/cm3
Melting Point155 °C
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 73384-59-5 |
| Catalog No. | 2A-9009682 |
| Chinese Name | 头孢曲松 |
| Synonyms | Ceftriazone; Biotrakson; Rocefin; Ceftriaxone; ceftriaxonum [INN_la]; ceftriaxome; Ceftriaxone [USAN:JAN]; Antibiotic Ro-13-9904; Cefatriaxone; MFCD00865013; EINECS 277-405-6; Rocephin |
| Molecular Formula | C18H18N8O7S3 |
| Molecular Weight | 554.59 |
| Purity | 98 |
| Density | 2.0±0.1 g/cm3 |
| Melting Point | 155 °C |
| Storage Condition | 2-8℃ |
| Application | Ceftriaxone is an antibiotic that binds to PBPs. |
| HTC | 3003201700 |
| MDL Number | C18H18N8O7S3 |
| SMILES | CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(=O)[nH]n3C)CSC12)c1csc(N)n1 |
| InChI | InChI=1S/C18H18N8O7S3.Na/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);/q;+1/p-1/b24-8-;/t9-,15-;/m1./s1 |
| InChI Key | VAAUVRVFOQPIGI-RFAUZJTJSA-N |
| MSDS | msds/9682_1_73384_59_5.pdf |
| Use of | Ceftriaxone is an antibiotic useful for the treatment of a number of bacterial infections.Target: AntibacterialCeftriaxone inhibits bacterial cell wall synthesis by means of binding to the penicillin-binding proteins (PBPs). Inhibition of PBPs would in turn inhibit the transpeptidation step in peptidoglycan synthesis which is required for bacterial cell walls. Like other cephalosporins, ceftriaxone is bacteriocidal and exhibits time-dependent killing. Ceftriaxone, one of the beta-lactam antibiotics, is a stimulator of EAAT2 expression with neuroprotective effects in both in vitro and in vivo models based in part on its ability to inhibit neuronal cell death by glutamate excitotoxicity. Based on this consideration and its lack of toxicity, ceftriaxone has potential to manipulate glutamate transmission and ameliorate neurotoxicity [1]. Properties Name ceftriaxone Synonym More Synonyms Ceftriaxone Biological Activity Description Ceftriaxone is an antibiotic useful for the treatment of a number of bacterial infections.Target: AntibacterialCeftriaxone inhibits bacterial cell wall synthesis by means of binding to the penicillin-binding proteins (PBPs). Inhibition of PBPs would in turn inhibit the transpeptidation step in peptidoglycan synthesis which is required for bacterial cell walls. Like other cephalosporins, ceftriaxone is bacteriocidal and exhibits time-dependent killing. Ceftriaxone, one of the beta-lactam antibiotics, is a stimulator of EAAT2 expression with neuroprotective effects in both in vitro and in vivo models based in part on its ability to inhibit neuronal cell death by glutamate excitotoxicity. Based on this consideration and its lack of toxicity, ceftriaxone has potential to manipulate glutamate transmission and ameliorate neurotoxicity [1]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Lee, S.G., et al., Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. J Biol Chem, 2008. 283(19): p. 13116-23. Chemical & Physical Properties Molecular Formula C18H18N8O7S3 Exact Mass 554.046082 PSA 293.80000 LogP -0.77 Index of Refraction 1.889 InChIKey VAAUVRVFOQPIGI-RFAUZJTJSA-N Storage condition 2-8℃ Safety Information Hazard Codes Xn WGK Germany 3 HS Code 3003201700 Synthetic Route 7-[4-bromo-2(Z)... CAS#:79232-67-0 CAS#:17356-08-0 Ceftriaxone CAS#:73384-59-5 CAS#:74578-70-4 Ceftriaxone CAS#:73384-59-5 (6R,7R)-3-(Acet... CAS#:60846-21-1 Thiotriazinone CAS#:58909-39-0 Ceftriaxone CAS#:73384-59-5 Precursor & DownStream Precursor 3 CAS#:79232-67-0 7-[4-bromo-2(Z)... CAS#:614751-38-1 (6R,7R)-7-((Z)-... CAS#:58909-39-0 Thiotriazinone DownStream 1 CAS#:74578-69-1 Ceftriaxone sodium |
| Transport Info | Product Name: Ceftriaxone |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Cefotaxime | 63527-52-6 | 2A-9009651 |
| Cefotaxime sodium | 64485-93-4 | 2A-9009652 |
| Ceftazidime | 72558-82-8 | 2A-9009670 |
| Ceftazidime dihydrochloride | 73547-70-3 | 2A-9009671 |
| Ceftriaxone sodium | 104376-79-6 | 2A-9009681 |
| Cefuroxime axetil | 55268-75-2 | 2A-9009684 |
| Cefuroxime sodium | 56238-63-2 | 2A-9009685 |
| Celecoxib | 169590-42-5 | 2A-9009688 |
| Cephalexin | 15686-71-2 | 2A-9009695 |
| Cephalexin monhydrochloride | 23325-78-2 | 2A-9009696 |
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