CAS Number154-93-8
Synonyms1,3-bis(2-Chlorethyl)-1-nitrosourea; Bicnu; Becenun; Carmustine; BCNU; EINECS 205-838-2; MFCD00057706; 1,3-Bis(2-chloroethyl)-1-nitrosourea; Carustine; 1,3-Bis(2-chloroethyl)-1-nitrosourea BCNU
Molecular FormulaC5H9Cl2N3O2
Molecular Weight214.05
Purity≥98%
Density1.5±0.1 g/cm3
Boiling Point404ºC
Melting Point30 °C (lit.)
Appearance(Oily liquid to amorphous solid)
EINECS205-838-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 154-93-8 |
| Catalog No. | 2A-9009599 |
| Chinese Name | 卡莫司汀 |
| Synonyms | 1,3-bis(2-Chlorethyl)-1-nitrosourea; Bicnu; Becenun; Carmustine; BCNU; EINECS 205-838-2; MFCD00057706; 1,3-Bis(2-chloroethyl)-1-nitrosourea; Carustine; 1,3-Bis(2-chloroethyl)-1-nitrosourea BCNU |
| Molecular Formula | C5H9Cl2N3O2 |
| Molecular Weight | 214.05 |
| Purity | ≥98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 404ºC |
| Melting Point | 30 °C (lit.) |
| Appearance | (Oily liquid to amorphous solid) |
| Water Solubility | <0.1 g/100 mL at 18 ºC |
| Storage Condition | Store in a cool, dry, ventilated place; away from |
| Packaging | II |
| Application | Carmustine is an anti-tumor chemotherapeutic agent that is an alkylating agent for DNA and RNA. |
| EINECS | 205-838-2 |
| HTC | 2924199090 |
| PubChem ID | 24278289 |
| MDL Number | MFCD00057706 |
| SMILES | ClCCNC(=O)N(CCCl)N=O |
| InChI | 1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11) |
| InChI Key | DLGOEMSEDOSKAD-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/9599_1_154_93_8.pdf |
| Bioactivity | Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker Research Areas >> Cancer Target DNA Alkylator[1] In Vitro Carmustine is an antitumor chemotherapeutic agent. Carmustine (8, 80, and 800 µM) decreases N-acetyltransferase (NAT) activities for 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) in rat glial tumor cytosol and intact cells. In rat glial tumor cells, the DNA-AF adduct increases, and carmustine decreases the formation of DNA-AF adduct[1]. In Vivo Carmustine (BCNU; 25 mg/kg, i.p.) causes higher levels of the rhe ratio of liver weight to body weight and plasma conjugated bilirubin, and lower biliary flow, oxidised glutation levels (GSSG) and reduced glutation (GSH)/GSSG values compared with control rats[2]. Kinase Assay The determination of Acetyl-CoAdependent N-acetylation of 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) are performed. Incubation mixtures in the assay system consists of a total volume of 90 μL: glial tumor cells cytosols, diluted as required, in 50 μL of lysis buffer (20 mM Tris/HCl, pH 7.5, 1 mM DTT and 1 mM EDTA), 20 μL of an Acetyl-CoA recycling mixture of 50 mM Tris-HCl (pH7.5), 0.2 mM EDTA, 2 mM DTT, 15 mM acetylcamitine, 2U/mL carnitine acetyltransferase, and AF or PABA at specific concentrations. The reactions are started by addition of 20 μL of Acetyl-CoA. The control reactions have 20 μL distilled water in place of Acetyl-CoA. For the single point activity measurements, the final concentration of AF or PABA is 0.1 mM and AcCoA is 0.5 mM. The reaction mixtures with or without specific concentrations of Carmustine and lomustine are incubated at 37°C for 10 min and stopped with 50 μL of 20% trichloroacetic acid for the PABA reactions, and 100 μL of acetonitrile for the AF reactions. All of the reactions (experiments and controls) are run in triplicate[1]. Animal Admin Rats[2] Individual rats are weighted prior to enter the study; their weights are recorded, and they are randomLy assigned to four groups. Group I (saline group); This group consists of 12 rats. These rats are injected with 2 mL/kg of saline intraperitoneally (IP) 48 h before the study, being included by the study 48 h later. Group II (corn oil group) consists of 15 rats. These rats are injected with 2 mL/kg of corn oil (vehicle) IP 48 h before the study. Group III (Carmustine group) consists of 16 rats. These rats are injected with 1 mL per day of saline IP, administered at the same hour of the day as a single-dose for 3 days. Twelve hours after the first dose of saline, corn oil 2 mL/kg + Carmustine 25 mg/kg IP are injected, and the rats are included in the study 48 h after the administration of corn oil + Carmustine. Group IV (trimetazidine group) consists of 12 rats. These rats are injected with 2.5 mg/kg per day of trimetazidine (TMZ) IP, administered at the same hour of the day as a single-dose for 3 days. 12 h after the first dose of TMZ, corn oil 2 mL/kg + Carmustine 25 mg/kg IP are injected, and the rats are included in the study 48 h after the administration of corn oil + Carmustine[2]. References [1]. Hung CF. Effects of carmustine and lomustine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in rat glial tumor cells. Neurochem Res. 2000 Jun;25(6):845-51. [2]. Demir A, et al. The effect of trimetazidine on intrahepatic cholestasis caused by carmustine in rats. Hepatol Res. 2001 May 1;20(1):133-143. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 404ºC Melting Point 30 °C(lit.) Molecular Formula C5H9Cl2N3O2 Molecular Weight 214.050 Exact Mass 213.007187 PSA 61.77000 LogP 1.30 Index of Refraction 1.549 InChIKey DLGOEMSEDOSKAD-UHFFFAOYSA-N SMILES O=NN(CCCl)C(=O)NCCCl Water Solubility <0.1 g/100 mL at 18 ºC |
| Use of | Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA. Properties Articles71 Name carmustine Synonym More Synonyms Carmustine Biological Activity Description Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker Research Areas >> Cancer DNA Alkylator[1] In Vitro Carmustine is an antitumor chemotherapeutic agent. Carmustine (8, 80, and 800 µM) decreases N-acetyltransferase (NAT) activities for 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) in rat glial tumor cytosol and intact cells. In rat glial tumor cells, the DNA-AF adduct increases, and carmustine decreases the formation of DNA-AF adduct[1]. References [1]. Hung CF. Effects of carmustine and lomustine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in rat glial tumor cells. Neurochem Res. 2000 Jun;25(6):845-51. [2]. Demir A, et al. The effect of trimetazidine on intrahepatic cholestasis caused by carmustine in rats. Hepatol Res. 2001 May 1;20(1):133-143. Chemical & Physical Properties Exact Mass 213.007187 PSA 61.77000 Index of Refraction 1.549 InChIKey DLGOEMSEDOSKAD-UHFFFAOYSA-N SMILES O=NN(CCCl)C(=O)NCCCl |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Carmustine) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Carmustine) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Carmustine) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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