CAS Number61422-45-5
SynonymsHexylcarbamoyl fluorouracil; 5-Fluoro-N-hexyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinecarboxamide; Mifurol; 5-Fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide; Carmofur; HCFU; 5-Fluoro-1-(hexylcarbamoyl)uracil; 5-fluoro-1-(n-hexylcarbamoyl)uracil; MFCD00866284; 1-hexylcarbamoyl-5-fluorouracil; Carmofurum [INN-Latin]; 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidine-1-carboxylic acid hexylamide; 1-(n-Hexylcarbamoyl)-5-fluorouracil; Yamaful
Molecular FormulaC11H16FN3O3
Molecular Weight257.26
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Melting Point110-111
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 61422-45-5 |
| Catalog No. | 2A-9009598 |
| Chinese Name | 氟脲己胺 |
| Synonyms | Hexylcarbamoyl fluorouracil; 5-Fluoro-N-hexyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinecarboxamide; Mifurol; 5-Fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide; Carmofur; HCFU; 5-Fluoro-1-(hexylcarbamoyl)uracil; 5-fluoro-1-(n-hexylcarbamoyl)uracil; MFCD00866284; 1-hexylcarbamoyl-5-fluorouracil; Carmofurum [INN-Latin]; 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidine-1-carboxylic acid hexylamide; 1-(n-Hexylcarbamoyl)-5-fluorouracil; Yamaful |
| Molecular Formula | C11H16FN3O3 |
| Molecular Weight | 257.26 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Melting Point | 110-111 |
| Appearance | powder |
| Water Solubility | Water solubility: insoluble; soluble in: chlorofor |
| Storage Condition | Store in a sealed container in a cool, dry place |
| Application | Carmofur is a fluorouracil derivative with anti-metabolic and anti-tumor activity. |
| HTC | 2933599090 |
| PubChem ID | 329774890 |
| MDL Number | MFCD00866284 |
| SMILES | CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O |
| InChI | 1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18) |
| InChI Key | AOCCBINRVIKJHY-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/9598_1_61422_45_5.pdf |
| Bioactivity | Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent. Target: Nucleoside antimetabolite/analogCarmofur, which is used in the clinic to treat colorectal cancers, is a potent AC inhibitor and that this property is essential to its anti-proliferative effects. Carmofur inhibited AC activity with a median effective concentration (IC50) of 29 ± 5 nM (mean ± standard error of the mean, s.e.m.; n = 4), whereas 5-FU had no such effect (IC50>1 mM). systemic administration of carmofur (10 or 30 mg-kg-1, intraperitoneal, i.p.) to mice produced a dose-dependent inhibition of AC activity in various tissues, including lungs and brain cortex. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Cancer References [1]. Realini, N., et al., Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep, 2013. 3: p. 1035. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Melting Point 110-111 Molecular Formula C11H16FN3O3 Molecular Weight 257.261 Exact Mass 257.117584 PSA 83.96000 LogP 2.58 Index of Refraction 1.525 InChIKey AOCCBINRVIKJHY-UHFFFAOYSA-N SMILES CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O Storage condition 2-8°C |
| Use of | Properties Articles27 Name 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide Synonym More Synonyms Carmofur Biological Activity Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Cancer References [1]. Realini, N., et al., Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep, 2013. 3: p. 1035. Chemical & Physical Properties Molecular Formula C11H16FN3O3 Exact Mass 257.117584 PSA 83.96000 Index of Refraction 1.525 InChIKey AOCCBINRVIKJHY-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (CARMOFUR) International Maritime Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (CARMOFUR) International Air Transport Regulations: Toxic solid, organic, n.o.s. (CARMOFUR) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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