CAS Number57775-29-8
SynonymsConduction; 1-(9H-Carbazol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol; 1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol; carazolol; CARAZOLOL HYDROCHLORIDE; 1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol; EINECS 260-945-1; 1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol; suacron; MFCD03428052; Carazololum; Conducton
Molecular FormulaC18H22N2O2
Molecular Weight298.38
Purity≥98.5 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point531.2±40.0 °C at 760 mmHg
Melting Point133-137 °C
AppearanceLight yellow solid
EINECS260-945-1
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57775-29-8 |
| Catalog No. | 2A-9009569 |
| Chinese Name | 咔唑心安 |
| Synonyms | Conduction; 1-(9H-Carbazol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol; 1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol; carazolol; CARAZOLOL HYDROCHLORIDE; 1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol; EINECS 260-945-1; 1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol; suacron; MFCD03428052; Carazololum; Conducton |
| Molecular Formula | C18H22N2O2 |
| Molecular Weight | 298.38 |
| Purity | ≥98.5 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 531.2±40.0 °C at 760 mmHg |
| Melting Point | 133-137 °C |
| Appearance | Light yellow solid |
| Storage Condition | Stable under normal temperature and pressure, avoi |
| Packaging | III |
| Application | Carazolol is a highly effective β1/β2 adrenoceptor antagonist used in hypertension research. Carazolol is also a potent and selective β3-adrenoceptor agonist [1]. |
| EINECS | 260-945-1 |
| HTC | 2933990090 |
| PubChem ID | 329757996 |
| MDL Number | MFCD00864588 |
| SMILES | CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12 |
| InChI | 1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3 |
| InChI Key | BQXQGZPYHWWCEB-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3620576 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9569_1_57775_29_8.pdf |
| Bioactivity | Carazolol is a β1/β2 adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β3-adrenoceptor agonist[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Target β1 adrenoceptor β2 adrenoceptor β3 adrenoceptor In Vivo Carazolol (0.01 mg/kg; i.m.; once) shows no significant side effects[2]. Animal Model: Kivircik sheeps, 25-45 kg, nonpregnant[2] Dosage: 0.01 mg/kg Administration: Intramuscular injection, once Result: Urea, creatinin, ALT, ALP, GGT, LDH, Ca, P, T.Protein, Mg, Cu levels in blood serum parameters were found to be in normal level however serum Fe, Zn levels were decreased. References [1]. A Méjean, et al. Carazolol: a potent, selective beta 3-adrenoceptor agonist. Eur J Pharmacol. 1995 Nov 30;291(3):359-66. [2]. Remzi Gonul, et al. Effects of carazolol on electrocadiographic and trace element status in sheeps. Insights Vet Sci. 2018; 2: 001- 004. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 531.2±40.0 °C at 760 mmHg Melting Point 133-137 °C Molecular Formula C18H22N2O2 Molecular Weight 298.38 Flash Point 275.1±27.3 °C Exact Mass 298.168121 PSA 57.28000 LogP 3.59 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.652 InChIKey BQXQGZPYHWWCEB-UHFFFAOYSA-N SMILES CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12 |
| Use of | Properties Articles31 Name carazolol hcl Synonym More Synonyms carazolol Biological Activity Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor β1 adrenoceptor β2 adrenoceptor β3 adrenoceptor References [1]. A Méjean, et al. Carazolol: a potent, selective beta 3-adrenoceptor agonist. Eur J Pharmacol. 1995 Nov 30;291(3):359-66. [2]. Remzi Gonul, et al. Effects of carazolol on electrocadiographic and trace element status in sheeps. Insights Vet Sci. 2018; 2: 001- 004. Chemical & Physical Properties Molecular Formula C18H22N2O2 Exact Mass 298.168121 PSA 57.28000 Index of Refraction 1.652 InChIKey BQXQGZPYHWWCEB-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: III |
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