CAS Number130641-38-2
Synonyms2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid; Bindarit (USAN/INN); 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid; bindarit
Molecular FormulaC19H20N2O3
Molecular Weight324.37
Purity≥98 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point542.9±40.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 130641-38-2 |
| Catalog No. | 2A-9009407 |
| Chinese Name | 宾达利 |
| Synonyms | 2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid; Bindarit (USAN/INN); 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid; bindarit |
| Molecular Formula | C19H20N2O3 |
| Molecular Weight | 324.37 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 542.9±40.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | Room temperature, dry, sealed |
| Application | Bindarit (AF-2838) is a CCL2, CCL7 and CCL8 inhibitor with anti-inflammatory activity. |
| HTC | 2933990090 |
| MDL Number | MFCD00866723 |
| SMILES | [n]2(nc(c3c2cccc3)COC(C)(C)C(=O)O)Cc1ccccc1 |
| InChI | 1S/C19H20N2O3/c1-19(2,18(22)23)24-13-16-15-10-6-7-11-17(15)21(20-16)12-14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3,(H,22,23) |
| InChI Key | MTHORRSSURHQPZ-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| MSDS | msds/9407_1_130641_38_2.pdf |
| Use of | Properties Name 2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid Synonym More Synonyms Bindarit Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Zoja, C., et al., Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int, 1998. 53(3): p. 726-34. [2]. Gazzaniga, S., et al., Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft. J Invest Dermatol, 2007. 127(8): p. 2031-41. [3]. Grassia, G., et al., The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovasc Res, 2009. 84(3): p. 485-93. [4]. Zollo, M., et al., Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models. Clin Exp Metastasis, 2012. 29(6): p. 585-601. Chemical & Physical Properties Molecular Formula C19H20N2O3 Exact Mass 324.147400 PSA 64.35000 Index of Refraction 1.595 InChIKey MTHORRSSURHQPZ-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route 1-Benzyl-3-Iodo... CAS#:205643-28-3 CAS#:130641-38-2 Benzyl bromide CAS#:100-39-0 CAS#:130641-38-2 3-Bromo-1H-indazole CAS#:40598-94-5 CAS#:130641-38-2 Precursor & DownStream Precursor 6 CAS#:205643-28-3 1-Benzyl-3-Iodo... CAS#:100-39-0 Benzyl bromide CAS#:40598-94-5 3-Bromo-1H-indazole CAS#:131427-21-9 1-BENZYL-3-HYDR... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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