CAS Number603-50-9
SynonymsLA96A; laco; neolax; zetrax; durolax; laxine; EINECS 210-044-4; MFCD00038039; ivilax; Bicol; deficol; Laxans
Molecular FormulaC22H19NO4
Molecular Weight361.39
Purity99%
Density1.2 g/cm3
Boiling Point492ºC
Melting Point131 - 135ºC
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 603-50-9 |
| Catalog No. | 2A-9009411 |
| Chinese Name | 比沙可啶 |
| Synonyms | LA96A; laco; neolax; zetrax; durolax; laxine; EINECS 210-044-4; MFCD00038039; ivilax; Bicol; deficol; Laxans |
| Molecular Formula | C22H19NO4 |
| Molecular Weight | 361.39 |
| Purity | 99 |
| Density | 1.2 g/cm3 |
| Boiling Point | 492ºC |
| Melting Point | 131 - 135ºC |
| Appearance | White to off-white crystalline powder |
| Storage Condition | 2-8°C |
| Application | Bisacodyl is a stimulant laxative that directly stimulates the colon to produce bowel movements. |
| HTC | 2942000000 |
| PubChem ID | 329749117 |
| MDL Number | MFCD00038039 |
| SMILES | CC(=O)Oc1ccc(cc1)C(c2ccc(OC(C)=O)cc2)c3ccccn3 |
| InChI | 1S/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3 |
| InChI Key | KHOITXIGCFIULA-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9411_1_603_50_9.pdf |
| Bioactivity | Bisacodyl is a stimulant laxative drug that works directly on the colon to produce a bowel movement.Target: OthersBisacodyl is an organic compound that is used as a stimulant laxative drug. Bisacodyl (20 mg/kg) results in a decrease in AQP3 protein expression and increased mRNA expression level of TNF-α in the colon of rats [1]. Bisacodyl inhibits water absorption in rat jejunum, ileum, and colon, the degree of inhibition is linearly related to the logarithm of the bisacodyl concentration over the range of 0.05 mg to 2.0 mg per 100 mL [2]. Bisacodyl (10 mg/kg, intragastrically) induces a significant decrease in jejunal NOS activity in rats. Bisacodyl (10 mg/kg, intragastrically) increases the distance traveled by the marker in all time periods [3]. Bisacodyl (5.9 mg/kg) decreases significantly jejunal and colonic (Na + K) ATPase activity as compared to saline-treated rats. Bisacodyl (5.9 mg/kg) increases significantly jejunal and colonic PGE2 content and stimulates jejunal and colonic adenyl cyclase activity as compared to those in control rats without affecting cAMP content [4]. Bisacodyl (4.3 mg/kg) coupled with AOM increases the number of crypt per focus, but not the number of tumors in rats. Bisacodyl (43 mg/kg) significantly increases the number of crypt per focus and tumors in rats [5]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Ikarashi, N., et al., The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am J Physiol Gastrointest Liver Physiol, 2011. 301(5): p. G887-95. [2]. Saunders, D.R., et al., Effect of bisacodyl on the structure and function of rodent and human intestine. Gastroenterology, 1977. 72(5 Pt 1): p. 849-56. [3]. Karmeli, F., R. Stalnikowicz, and D. Rachmilewitz, Effect of colchicine and bisacodyl on rat intestinal transit and nitric oxide synthase activity. Scand J Gastroenterol, 1997. 32(8): p. 791-6. [4]. Rachmilewitz, D., F. Karmeli, and E. Okon, Effects of bisacodyl on cAMP and prostaglandin E2 contents, (Na + K) ATPase, adenyl cyclase, and phosphodiesterase activities of rat intestine. Dig Dis Sci, 1980. 25(8): p. 602-8. [5]. Borrelli, F., et al., Effect of bisacodyl and cascara on growth of aberrant crypt foci and malignant tumors in the rat colon. Life Sci, 2001. 69(16): p. 1871-7. Chemical & Physical Properties Density 1.2 g/cm3 Boiling Point 492ºC Melting Point 131 - 135ºC Molecular Formula C22H19NO4 Molecular Weight 361.39100 Exact Mass 361.13100 PSA 65.49000 LogP 4.11240 InChIKey KHOITXIGCFIULA-UHFFFAOYSA-N SMILES CC(=O)Oc1ccc(C(c2ccc(OC(C)=O)cc2)c2ccccn2)cc1 Storage condition 2-8°C Stability Stable. Incompatible with strong oxidizing agents. |
| Use of | Properties Articles28 Name Bisacodyl Synonym More Synonyms Bisacodyl Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Ikarashi, N., et al., The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am J Physiol Gastrointest Liver Physiol, 2011. 301(5): p. G887-95. [3]. Karmeli, F., R. Stalnikowicz, and D. Rachmilewitz, Effect of colchicine and bisacodyl on rat intestinal transit and nitric oxide synthase activity. Scand J Gastroenterol, 1997. 32(8): p. 791-6. [5]. Borrelli, F., et al., Effect of bisacodyl and cascara on growth of aberrant crypt foci and malignant tumors in the rat colon. Life Sci, 2001. 69(16): p. 1871-7. Chemical & Physical Properties Molecular Formula C22H19NO4 Exact Mass 361.13100 PSA 65.49000 LogP 4.11240 InChIKey KHOITXIGCFIULA-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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