CAS Number635-65-4
Synonyms(4Z,15Z)-Bilirubin IXa; Biliyubin; filirubin; Cholerythrin; EINECS 211-239-7; (Z,Z)-Bilirubin; bilirubin; 1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinyl-(b-13)-dihydrobilenone; hemetoidin; (Z,Z)-Bilirubin IXa; Bilirubin IXa; MFCD00005499
Molecular FormulaC33H36N4O6
Molecular Weight584.66
Purity≥98 (E<FRAC Type="vertical">mM/453</FRAC> = 60)%
Density1.2163
Boiling Point641.7°C
Melting Point192 °C
Appearancepowder
EINECS211-239-7
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 635-65-4 |
| Catalog No. | 2A-9009403 |
| Chinese Name | 胆红素 |
| Synonyms | (4Z,15Z)-Bilirubin IXa; Biliyubin; filirubin; Cholerythrin; EINECS 211-239-7; (Z,Z)-Bilirubin; bilirubin; 1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinyl-(b-13)-dihydrobilenone; hemetoidin; (Z,Z)-Bilirubin IXa; Bilirubin IXa; MFCD00005499 |
| Molecular Formula | C33H36N4O6 |
| Molecular Weight | 584.66 |
| Purity | ≥98 (E<FRAC Type="vertical">mM/453</FRAC> = 60) |
| Density | 1.2163 |
| Boiling Point | 641.7°C |
| Melting Point | 192 °C |
| Appearance | powder |
| Water Solubility | Insoluble |
| Storage Condition | Sealed packaging in brown glass bottles. Store in |
| Application | Bilirubin is a yellow breakdown product of heme catabolism and is an important indicator of liver function. |
| EINECS | 211-239-7 |
| HTC | 29339990 |
| PubChem ID | 24891751 |
| MDL Number | MFCD00005499 |
| SMILES | CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C |
| InChI | 1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14- |
| InChI Key | BPYKTIZUTYGOLE-IFADSCNNSA-N |
| Beilstein/REAXYS | 74376 |
| NACRES Code | NA.77 |
| UNSPSC | 12352202 |
| Hazard Symbols | Transport |
| MSDS | msds/9403_1_635_65_4.pdf |
| Bioactivity | Bilirubin is a yellow breakdown product of heme catabolism. Related Catalog Natural Products >> Acids and Aldehydes Research Areas >> Cardiovascular Disease Target Human Endogenous Metabolite In Vitro Unconjugated Bilirubin inhibits the cleavage of F485-rVWF73-H, D633-rVWF73-H, and GST-rVWF71-11K by ADAMTS13 in a concentration-dependent manner with a half-maximal inhibitory concentration (IC50) of ~13 μM, ~70 μM, and ~17 μM, respectively. Unconjugated Bilirubin also dose-dependently inhibits the cleavage of multimeric VWF by ADAMTS13 under denaturing conditions[1]. Bilirubin exhibits antioxidant and antimutagenic effects in vitro[2]. References [1]. Lu RN, et al. Unconjugated Bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease. J Thromb Haemost. 2015 Jun;13(6):1064-72. [2]. Mölzer C, et al. Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide. J Nat Prod. 2013 Oct 25;76(10):1958-65. Chemical & Physical Properties Density 1.2163 Boiling Point 641.7°C Melting Point 192 °C Molecular Formula C33H36N4O6 Molecular Weight 584.662 Flash Point 478.1±37.1 °C Exact Mass 584.263489 PSA 164.38000 LogP 3.15 Vapour Pressure 0.0±0.3 mmHg at 25°C Index of Refraction 1.640 InChIKey BPYKTIZUTYGOLE-IFADSCNNSA-N SMILES C=CC1=C(C)C(=Cc2[nH]c(Cc3[nH]c(C=C4NC(=O)C(C)=C4C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O Storage condition −20°C Stability Stable. Refrigerate. |
| Use of | Bilirubin is a yellow breakdown product of heme catabolism. Properties Articles421 Name bilirubin Synonym More Synonyms bilirubin Biological Activity Description Bilirubin is a yellow breakdown product of heme catabolism. Related Catalog Natural Products >> Acids and Aldehydes Research Areas >> Cardiovascular Disease Human Endogenous Metabolite In Vitro Unconjugated Bilirubin inhibits the cleavage of F485-rVWF73-H, D633-rVWF73-H, and GST-rVWF71-11K by ADAMTS13 in a concentration-dependent manner with a half-maximal inhibitory concentration (IC50) of ~13 μM, ~70 μM, and ~17 μM, respectively. Unconjugated Bilirubin also dose-dependently inhibits the cleavage of multimeric VWF by ADAMTS13 under denaturing conditions[1]. Bilirubin exhibits antioxidant and antimutagenic effects in vitro[2]. References [1]. Lu RN, et al. Unconjugated Bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease. J Thromb Haemost. 2015 Jun;13(6):1064-72. [2]. Mölzer C, et al. Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide. J Nat Prod. 2013 Oct 25;76(10):1958-65. Chemical & Physical Properties Molecular Formula C33H36N4O6 Exact Mass 584.263489 PSA 164.38000 Index of Refraction 1.640 InChIKey BPYKTIZUTYGOLE-IFADSCNNSA-N Stability Stable. Refrigerate. |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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