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Amtolmetin guacil structure, CAS 87344-06-7

Amtolmetin guacil

CAS Number87344-06-7

Synonyms2-Methoxyphenyl N-{[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetyl}glycinate; amtolmetin guacil; Glycine, N-[2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetyl]-, 2-methoxyphenyl ester; MFCD00866153

Molecular FormulaC24H24N2O5

Molecular Weight420.46

Purity98%

Density1.2±0.1 g/cm3

Boiling Point663.3±55.0 °C at 760 mmHg

Melting Point117-120ºC

Flash Point

Appearancewhite needle crystal

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Cat. No.: 2A-9009186 Purity: 98%
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Quality Control of [ 87344-06-7 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number87344-06-7
Catalog No.2A-9009186
Chinese Name呱氨托美丁
Synonyms2-Methoxyphenyl N-{[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetyl}glycinate; amtolmetin guacil; Glycine, N-[2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetyl]-, 2-methoxyphenyl ester; MFCD00866153
Molecular FormulaC24H24N2O5
Molecular Weight420.46
Purity98
Density1.2±0.1 g/cm3
Boiling Point663.3±55.0 °C at 760 mmHg
Melting Point117-120ºC
Appearancewhite needle crystal
Storage ConditionRoom temperature, dry
ApplicationMethotrexate-citrulline is a potent non-steroidal anti-inflammatory drug with analgesic properties. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil stimu
MDL NumberC24H24N2O5
SMILESCOc1ccccc1OC(=O)CNC(=O)Cc1ccc(C(=O)c2ccc(C)cc2)n1C
InChIInChI=1S/C24H24N2O5/c1-16-8-10-17(11-9-16)24(29)19-13-12-18(26(19)2)14-22(27)25-15-23(28)31-21-7-5-4-6-20(21)30-3/h4-13H,14-15H2,1-3H3,(H,25,27)
InChI KeyCWJNMKKMGIAGDK-UHFFFAOYSA-N
MSDSmsds/9186_1_87344_06_7.pdf
BioactivityAmtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis[1][2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Target Prostaglandin receptor, COX, NO[1][2] In Vitro Amtolmetin guacil (100 μM; 0-60 min) converts to TMT (Tolmetin, HY-B1799) along with MED5 (1-methyl-5-p-methylbenzoyl-pyrrol-2-acetamido aceticacid) in rat fresh plasma and rat liver microsomal, rapidly converts to MED5 and MED5 methyl ester without yielding TMT in human fresh plasma and human liver microsomes[3]. In Vivo Animal Model: Male Wistar rats[3] Dosage: 50 mg/kg Administration: p.o.; single dosage Result: Pharmacokinetic Parameters of Amtolmetin guacil in male Wistar rats[3]. AUC0-t (ng/mL·h) AUC0-∞ (ng/mL·h) Cmax (μg/mL) Tmax (h) Kel (h-1) t1/2,β (h) TMT followingAmtolmetin guacil dosing 162 ± 21.49 164 ± 22.47 81.62 ± 5.02 0.50 ± 0.00 0.28 ± 0.00 2.41 ± 0.01 Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 663.3±55.0 °C at 760 mmHg Melting Point 117-120ºC Molecular Formula C24H24N2O5 Molecular Weight 420.458 Flash Point 354.9±31.5 °C Exact Mass 420.168518 PSA 86.63000 LogP 1.98 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.583 InChIKey CWJNMKKMGIAGDK-UHFFFAOYSA-N SMILES COc1ccccc1OC(=O)CNC(=O)Cc1ccc(C(=O)c2ccc(C)cc2)n1C
Use ofAmtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis[1][2]. Properties Name 2-Methoxyphenyl 2-(2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetamido)acetate Synonym More Synonyms Amtolmetin guacil Biological Activity Description Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis[1][2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Prostaglandin receptor, COX, NO[1][2] Chemical & Physical Properties Molecular Formula C24H24N2O5 Exact Mass 420.168518 PSA 86.63000 Index of Refraction 1.583 InChIKey CWJNMKKMGIAGDK-UHFFFAOYSA-N
Transport InfoProduct Name: Ampicillin
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