CAS Number68475-42-3
SynonymsBL 4162A; Anagrelide (INN/BAN); 6,7-di-chloro-1,5-dihydroimidazo[2,1-b]quinazolin-2[3 H ]-one base; Anagrelida; UNII-K9X45X0051; 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one; Anagrelide; 6,7-Dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one; Anagrelidum; 6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one; Anagrelidum [INN-Latin]; Agrelin; MFCD00866794; 6,7-dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one; 6,7-Dichloro-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one; Anagrelida [INN-Spanish]
Molecular FormulaC10H7O1N3Cl2
Molecular Weight256.09
Purity98%
Density1.8±0.1 g/cm3
Boiling Point376.5±52.0 °C at 760 mmHg
Melting Point280 °C
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68475-42-3 |
| Catalog No. | 2A-9009189 |
| Chinese Name | 阿那格雷 |
| Synonyms | BL 4162A; Anagrelide (INN/BAN); 6,7-di-chloro-1,5-dihydroimidazo[2,1-b]quinazolin-2[3 H ]-one base; Anagrelida; UNII-K9X45X0051; 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one; Anagrelide; 6,7-Dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one; Anagrelidum; 6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one; Anagrelidum [INN-Latin]; Agrelin; MFCD00866794; 6,7-dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one; 6,7-Dichloro-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one; Anagrelida [INN-Spanish] |
| Molecular Formula | C10H7O1N3Cl2 |
| Molecular Weight | 256.09 |
| Purity | 98 |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 376.5±52.0 °C at 760 mmHg |
| Melting Point | 280 °C |
| Water Solubility | slightly soluble |
| Storage Condition | 2-8°C |
| Application | Anagrelide, a phosphodiesterase type III (PDEIII) inhibitor (IC50=36 nM), inhibits platelet production. Anagrelide is an imidazoquinazoline derivative that acts as an inhibitor of platelet aggregation |
| HTC | 2933990090 |
| MDL Number | MFCD09027973 |
| SMILES | O=C1CN2Cc3c(ccc(Cl)c3Cl)N=C2N1 |
| InChI | InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16) |
| InChI Key | OTBXOEAOVRKTNQ-UHFFFAOYSA-N |
| Hazard Symbols | 2.2 |
| MSDS | msds/9189_1_68475_42_3.pdf |
| Use of | Anagrelide, an inhibitor of phosphodiesterase type III (PDEIII) (IC50=36 nM), inhibits platelet production. Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide plays in the antithrombopoietic action. The platelet-lowering agent[1]. Properties Name anagrelide Synonym More Synonyms Anagrelide Biological Activity Description Anagrelide, an inhibitor of phosphodiesterase type III (PDEIII) (IC50=36 nM), inhibits platelet production. Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide plays in the antithrombopoietic action. The platelet-lowering agent[1]. Related Catalog Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) References [1]. Guosu Wang, et al. Comparison of the biological activities of Anagrelide and its major metabolites in haematopoietic cell cultures. Br J Pharmacol. 2005 Oct;146(3):324-32. [2]. Y Hong, et al. Comparison between Anagrelide and hydroxycarbamide in their activities against haematopoietic progenitor cell growth and differentiation: selectivity of Anagrelide for the megakaryocytic lineage. Leukemia. 2006 Jun;20(6):1117-22. [3]. Olli-Pekka Pulkka, et al. Anagrelide for Gastrointestinal Stromal Tumor. Clin Cancer Res. 2019 Mar 1;25(5):1676-1687. Chemical & Physical Properties Exact Mass 254.996613 PSA 44.70000 Index of Refraction 1.791 InChIKey OTBXOEAOVRKTNQ-UHFFFAOYSA-N Water Solubility slightly soluble Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro- CAS REGISTRY NUMBER : 68475-42-3 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C10-H7-Cl2-N3-O MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : DOSE/DURATION : 300 ug/kg/7D TOXIC EFFECTS : Behavioral - headache Gastrointestinal - other changes REFERENCE : PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 29,212,1988 Safety Information Safety Phrases S3-S7 RIDADR 3163 Hazard Class 2.2 HS Code 2933990090 Synthetic Route Total: 1 Page ethyl 2-[5,6-di... CAS#:146374-56-3 Anagrelide CAS#:68475-42-3 Literature: US5391737 A1, ; CAS#:146374-57-4 Anagrelide CAS#:68475-42-3 Literature: US5391737 A1, ; Ethyl-5,6-dichl... CAS#:70381-75-8 Anagrelide CAS#:68475-42-3 Precursor & DownStream Precursor 2 CAS#:146374-56-3 ethyl 2-[5,6-di... CAS#:70381-75-8 Ethyl-5,6-dichl... DownStream 1 CAS#:58579-51-4 Anagrelide HCl |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Amprenavir | 161814-49-9 | 2A-9009183 |
| Amprolium hydrochloride | 137-88-2 | 2A-9009184 |
| Amrinone | 60719-84-8 | 2A-9009185 |
| Amtolmetin guacil | 87344-06-7 | 2A-9009186 |
| Amygdalin | 29883-15-6 | 2A-9009187 |
| Anagrelide hydrochloride | 5879-51-4 | 2A-9009190 |
| Anagyrine | 486-89-5 | 2A-9009191 |
| Analgin | 68-89-3 | 2A-9009192 |
| Anatoxin a | 64285-06-9 | 2A-9009194 |
| Ancarolol | 75748-50-4 | 2A-9009195 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS