CAS Number60719-84-8
SynonymsAmrinona; Cordemcura; Wincoram; Amrinon; Amrinone; 5-Amino-3,4'-bipyridin-6-ol; Inocor; MFCD00083228; Inamrinone; Amrinonum; Amcoral; EINECS 262-390-0; 5-Amino-3,4'-bipyridin-6(1H)-one
Molecular FormulaC10H9N3O
Molecular Weight187.20
Purity98%
Density1.3±0.1 g/cm3
Boiling Point451.5±45.0 °C at 760 mmHg
Melting Point294-297ºC
Appearancecrystalline solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 60719-84-8 |
| Catalog No. | 2A-9009185 |
| Chinese Name | 氨力农 |
| Synonyms | Amrinona; Cordemcura; Wincoram; Amrinon; Amrinone; 5-Amino-3,4'-bipyridin-6-ol; Inocor; MFCD00083228; Inamrinone; Amrinonum; Amcoral; EINECS 262-390-0; 5-Amino-3,4'-bipyridin-6(1H)-one |
| Molecular Formula | C10H9N3O |
| Molecular Weight | 187.20 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 451.5±45.0 °C at 760 mmHg |
| Melting Point | 294-297ºC |
| Appearance | crystalline solid |
| Storage Condition | Warehouse Ventilation Low Temperature Drying |
| Packaging | III |
| Application | Amrinone (Inamrinone) is an inotropic vasodilator. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also a |
| HTC | 29333999 |
| PubChem ID | 329749027 |
| MDL Number | MFCD00083228 |
| SMILES | NC1=CC(=CNC1=O)c2ccncc2 |
| InChI | 1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14) |
| InChI Key | RNLQIBCLLYYYFJ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/9185_1_60719_84_8.pdf |
| Bioactivity | Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent[1][2][3]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) In Vitro Amrinone (Inamrinone) produced a dose-dependent inhibition of ADP-induced rat platelet aggregation in vitro as well as ex vivo in rats. The proliferation of human aortic smooth muscle cells in culture stimulated with FBS or PDGF was also inhibited by amrinone[4]. In Vivo Amrinone (Inamrinone) is administered subcutaneously to rats at a dose of 10 mg/kg/day for 14 days, significant reduction of neointimal thickness was noted[4]. References [1]. A A Alousi, et al. The Beneficial Effect of Amrinone on Acute Drug-Induced Heart Failure in the Anaesthetised Dog. Cardiovasc Res. 1985 Aug;19(8):483-94. [2]. S Ichioka, et al. Clinical Use of Amrinone (A Selective Phosphodiesterase III Inhibitor) in Reconstructive Surgery. Plast Reconstr Surg. 2001 Dec;108(7):1931-7. [3]. T H LeJemtel, et al. Amrinone: A New Non-Glycosidic, Non-Adrenergic Cardiotonic Agent Effective in the Treatment of Intractable Myocardial Failure in Man. Circulation. 1979 Jun;59(6):1098-104. [4]. M Hachisu, et al. [Effects of Amrinone, an Inhibitor of c-AMP-specific Phosphodiesterases, on Neointimal Hyperplasia After Balloon Injury in Rats]. Nihon Yakurigaku Zasshi. 1998 Oct;112(4):267-74. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 451.5±45.0 °C at 760 mmHg Melting Point 294-297ºC Molecular Formula C10H9N3O Molecular Weight 187.198 Flash Point 226.9±28.7 °C Exact Mass 187.074554 PSA 71.77000 LogP -0.54 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.625 InChIKey RNLQIBCLLYYYFJ-UHFFFAOYSA-N SMILES Nc1cc(-c2ccncc2)c[nH]c1=O |
| Use of | Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent[1][2][3]. Properties Articles50 Name 3-amino-5-pyridin-4-yl-1H-pyridin-2-one Synonym More Synonyms Amrinone Biological Activity Description Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent[1][2][3]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) In Vitro Amrinone (Inamrinone) produced a dose-dependent inhibition of ADP-induced rat platelet aggregation in vitro as well as ex vivo in rats. The proliferation of human aortic smooth muscle cells in culture stimulated with FBS or PDGF was also inhibited by amrinone[4]. References [1]. A A Alousi, et al. The Beneficial Effect of Amrinone on Acute Drug-Induced Heart Failure in the Anaesthetised Dog. Cardiovasc Res. 1985 Aug;19(8):483-94. [2]. S Ichioka, et al. Clinical Use of Amrinone (A Selective Phosphodiesterase III Inhibitor) in Reconstructive Surgery. Plast Reconstr Surg. 2001 Dec;108(7):1931-7. [3]. T H LeJemtel, et al. Amrinone: A New Non-Glycosidic, Non-Adrenergic Cardiotonic Agent Effective in the Treatment of Intractable Myocardial Failure in Man. Circulation. 1979 Jun;59(6):1098-104. [4]. M Hachisu, et al. [Effects of Amrinone, an Inhibitor of c-AMP-specific Phosphodiesterases, on Neointimal Hyperplasia After Balloon Injury in Rats]. Nihon Yakurigaku Zasshi. 1998 Oct;112(4):267-74. Chemical & Physical Properties Molecular Formula C10H9N3O Exact Mass 187.074554 PSA 71.77000 LogP -0.54 Index of Refraction 1.625 InChIKey RNLQIBCLLYYYFJ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Amrinone) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Amrinone) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Amrinone) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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