CAS Number69-52-3
Synonymsomnipen-n; Amcill-s; pena/n; Anhypen; XLD AGAR; penialmen; Alppen-N; EINECS 200-708-1; Alpen-n; Cilleral; sodium ampicillin salt; MFCD00064313; Ampicillin sodium; sodium ampicillin; Citteral; AmpicillinSodium; Ampicillin (sodium)
Molecular FormulaC16H18N3NaO4S
Molecular Weight371.39
Purity98%
Boiling Point683.9ºC at 760 mmHg
Melting Point215 °C (dec.) (lit.)
Appearanceliquid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 69-52-3 |
| Catalog No. | 2A-9009181 |
| Chinese Name | 氨苄西林钠 |
| Synonyms | omnipen-n; Amcill-s; pena/n; Anhypen; XLD AGAR; penialmen; Alppen-N; EINECS 200-708-1; Alpen-n; Cilleral; sodium ampicillin salt; MFCD00064313; Ampicillin sodium; sodium ampicillin; Citteral; AmpicillinSodium; Ampicillin (sodium) |
| Molecular Formula | C16H18N3NaO4S |
| Molecular Weight | 371.39 |
| Purity | 98 |
| Boiling Point | 683.9ºC at 760 mmHg |
| Melting Point | 215 °C (dec.) (lit.) |
| Appearance | liquid |
| Water Solubility | H2O: 50 mg/mL, clear, very faintly yellow |
| Storage Condition | This product should be sealed and stored dry at 4° |
| Application | Ampicillin sodium is a broad-spectrum beta-lactam antibiotic that can fight against a variety of Gram-positive and Gram-negative bacteria (bacteria). |
| HTC | 2941101900 |
| MDL Number | MFCD00064313 |
| SMILES | CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)[O-])C.[Na+] |
| InChI | 1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1 |
| InChI Key | KLOHDWPABZXLGI-YWUHCJSESA-M |
| Beilstein/REAXYS | 4119211 |
| NACRES Code | NA.76 |
| UNSPSC | 51280000 |
| MSDS | msds/9181_1_69_52_3.pdf |
| Bioactivity | Ampicillin sodium is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Target Bacterial[1] In Vitro Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL[1]. In Vivo Ampicillin is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig[1]. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood[2]. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia[3]. Animal Admin Mice: Ampicillin is dissolved in normal saline. Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral common carotid artery occlusion for 40 min. Before transient forebrain ischemia, ampicillin (200 mg/kg, intraperitoneally [i.p.]) or penicillin G (6,000 U/kg or 20,000 U/kg, i.p.) was administered daily for 5 days. In the control animals, saline was administered at the same volume and time schedule[3]. References [1]. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7. [2]. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7(2):133-5. [3]. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92. Chemical & Physical Properties Boiling Point 683.9ºC at 760 mmHg Melting Point 215 °C (dec.)(lit.) Molecular Formula C16H18N3NaO4S Molecular Weight 371.387 Exact Mass 371.091583 PSA 140.86000 LogP 0.01250 InChIKey KLOHDWPABZXLGI-YWUHCJSESA-M SMILES CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C(=O)[O-].[Na+] Water Solubility H2O: 50 mg/mL, clear, very faintly yellow |
| Use of | Ampicillin sodium is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. Properties Articles69 Name ampicillin sodium Synonym More Synonyms Ampicillin sodium Biological Activity Description Ampicillin sodium is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Bacterial[1] In Vitro Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL[1]. In Vivo Ampicillin is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig[1]. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood[2]. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia[3]. References [1]. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7. [2]. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7(2):133-5. [3]. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92. Chemical & Physical Properties Molecular Formula C16H18N3NaO4S Exact Mass 371.091583 PSA 140.86000 LogP 0.01250 InChIKey KLOHDWPABZXLGI-YWUHCJSESA-M |
| Transport Info | Product Name: Ampicillin Sodium |
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