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IBOTENIC ACID

Name: IBOTENIC ACID
Brand: 2A Biotech
SKU: 2A-9091671

CAS Number2552-55-8

SynonymsIbotenic acid; a-Amino-3-hydroxy-5-isoxazoleacetic Acid; a-Amino-2,3-dihydro-3-oxo-5-isoxazoleacetic Acid; Acide amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acétique; Amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetic acid; MFCD00069294; Amino-(3-hydroxy-5-isoxazolyl)acetic acid; 2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid

Molecular FormulaC5H6N2O4

Molecular Weight158.11

Purity98%

Density1.7±0.1 g/cm3

Boiling Point458.8±45.0 °C at 760 mmHg

Melting Point141-147 °C

Appearancewhite powder

MSDSChinese English

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Signal WordWarning

Cat. No.: 2A-9091671 Purity: 98%

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Quality Control of [ 2552-55-8 ] Purity: 98% SDS Specification MoL

Chemical & Physical Properties
CAS Number	2552-55-8
Catalog No.	2A-9091671
Chinese Name	鹅膏氨酸
Synonyms	Ibotenic acid; a-Amino-3-hydroxy-5-isoxazoleacetic Acid; a-Amino-2,3-dihydro-3-oxo-5-isoxazoleacetic Acid; Acide amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acétique; Amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetic acid; MFCD00069294; Amino-(3-hydroxy-5-isoxazolyl)acetic acid; 2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid
Molecular Formula	C5H6N2O4
Molecular Weight	158.11
Purity	98
Density	1.7±0.1 g/cm3
Boiling Point	458.8±45.0 °C at 760 mmHg
Melting Point	141-147 °C
Appearance	white powder
Storage Condition	Sealed in a cool, dry environment at -20ºC
Packaging	III
Application	Ibotenic acid has agonist activity at both N-methyl-D-aspartate (NMDA) and trans-ACPD or metabotropic quiescent acid (Qm) receptor sites.
SMILES	NC(C(=O)O)c1cc(=O)[nH]o1
InChI	InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
InChI Key	IRJCBFDCFXCWGO-UHFFFAOYSA-N
Hazard Symbols	6.1(b)
Bioactivity	Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Natural Products >> Acids and Aldehydes Research Areas >> Neurological Disease Target NMDA receptor[1] In Vitro Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media[1]. References [1]. Zinkand WC, et al. Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptormechanisms. Mol Chem Neuropathol. 1992 Feb-Apr;16(1-2):1-10. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 458.8±45.0 °C at 760 mmHg Melting Point 141-147 °C Molecular Formula C5H6N2O4 Molecular Weight 158.112 Flash Point 231.3±28.7 °C Exact Mass 158.032761 PSA 109.58000 LogP -1.07 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.610 InChIKey IRJCBFDCFXCWGO-UHFFFAOYSA-N SMILES NC(C(=O)O)c1cc(=O)[nH]o1 Storage condition -20°C
Use of	Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. Properties Articles55 Name Ibotenic acid Synonym More Synonyms Ibotenic acid Biological Activity Description Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Natural Products >> Acids and Aldehydes Research Areas >> Neurological Disease NMDA receptor[1] References [1]. Zinkand WC, et al. Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptormechanisms. Mol Chem Neuropathol. 1992 Feb-Apr;16(1-2):1-10. Chemical & Physical Properties Molecular Formula C5H6N2O4 Exact Mass 158.032761 PSA 109.58000 LogP -1.07 Index of Refraction 1.610 InChIKey IRJCBFDCFXCWGO-UHFFFAOYSA-N
Transport Info	Shipping Name: UN
MSDS Transport Info	Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3462 International Maritime Transport Danger Regulations: 3462 International Air Transport Danger Regulations: 3462 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXINS EXTRAC TED FROM LIVING SOURCES, SOLID, N.O.S. (α-Amino-3-hydroxy-5- isoxazoleacetic acid) IMDG: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. (α-Amino-3-hydroxy-5- isoxazoleacetic acid) International air transport hazard regulations: Toxins, extracted from living sources, solid, n.o.s. (α-Amino-3-hydroxy-5-isoxazoleacetic acid) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available

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IBOTENIC ACID

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