CAS Number124-87-8
SynonymsPicrotox; EINECS 204-716-6; PICROTOXIN; fishberry; indianberry; Picrotin - Picrotoxinin; picrotoxine; MFCD00074824; COCCULIN; COCCULINE; Cocculus
Molecular FormulaC15H18O7.C15H16O6
Molecular Weight602.58
Purity≥94 (mixture of Picrotoxin and picrotin, HPLC)%
Melting Point203 ℃(lit.)
Appearancecrystals
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 124-87-8 |
| Catalog No. | 2A-9091669 |
| Chinese Name | 木防己苦毒素 |
| Synonyms | Picrotox; EINECS 204-716-6; PICROTOXIN; fishberry; indianberry; Picrotin - Picrotoxinin; picrotoxine; MFCD00074824; COCCULIN; COCCULINE; Cocculus |
| Molecular Formula | C15H18O7.C15H16O6 |
| Molecular Weight | 602.58 |
| Purity | ≥94 (mixture of Picrotoxin and picrotin, HPLC) |
| Melting Point | 203 ℃(lit.) |
| Appearance | crystals |
| Storage Condition | -20°C |
| Packaging | I |
| Application | Picrotoxin is a noncompetitive GABAA receptor antagonist. |
| PubChem ID | 34673457 |
| MDL Number | MFCD00074824 |
| SMILES | O6[C@]87[C@H]6C[C@@]9([C@]8([C@H](OC7=O)C%10OC(=O)C9[C@@H]%10C(O)(C)C)C)O.O1[C@]32[C@@]4([C@H](OC3=O)C5OC(=O)C([C@@]4(CC21)O)[C@@H]5C(=C)C)C |
| InChI | 1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1 |
| InChI Key | VJKUPQSHOVKBCO-ZTYBEOBUSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/91669_1_124_87_8.pdf |
| Bioactivity | Picrotoxin is a noncompetitive antagonist of GABAA receptor. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease Natural Products >> Terpenoids and Glycosides References [1]. Boulanger JJ, et al. Oligodendrocyte progenitor cells are paired with GABA neurons in the mouse dorsal cortex: Unbiased stereological analysis. Neuroscience. 2017 Aug 18. pii: S0306-4522(17)30584-5. Chemical & Physical Properties Melting Point 203 ℃(lit.) Molecular Formula C15H18O7.C15H16O6 Molecular Weight 301.29 PSA 190.95000 InChIKey VJKUPQSHOVKBCO-UHFFFAOYSA-N SMILES C=C(C)C1C2OC(=O)C1C1(O)CC3OC34C(=O)OC2C14C.CC(C)(O)C1C2OC(=O)C1C1(O)CC3OC34C(=O)OC2C14C Storage condition -20°C |
| Use of | Picrotoxin is a noncompetitive antagonist of GABAA receptor. Properties Articles114 Synonym More Synonyms Picrotoxin Biological Activity Description Picrotoxin is a noncompetitive antagonist of GABAA receptor. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease Natural Products >> Terpenoids and Glycosides References [1]. Boulanger JJ, et al. Oligodendrocyte progenitor cells are paired with GABA neurons in the mouse dorsal cortex: Unbiased stereological analysis. Neuroscience. 2017 Aug 18. pii: S0306-4522(17)30584-5. Chemical & Physical Properties PSA 190.95000 InChIKey VJKUPQSHOVKBCO-UHFFFAOYSA-N |
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| VAL-TYR | 3061-91-4 | 2A-9091667 |
| RESINIFERATOXIN | 57444-62-9 | 2A-9091668 |
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| ZTP | 82989-82-0 | 2A-9091674 |
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