CAS Number2763-96-4
Synonyms5-(aminomethyl)-1,2-oxazol-3-one; 5-Aminomethyl-3-hydroxy-isoxazol; PANTHERINE; 5-(Aminomethyl)isoxazol-3(2H)-one; Agarine; 5-Aminomethyl-3-hydroxyisoxazole; 3-Hydroxy-5-aminomethylisoxazole; MFCD00057894; 5-aminomethyl-isoxazol-3-one; Agarin; EINECS 220-430-4; 5-(Aminomethyl)-1,2-oxazol-3(2H)-one; Pantherin; 3-Hydroxy-5-aminomethyl-isoxazole 5-Aminomethyl-3-hydroxy-isoxazole 5-Aminomethyl-3-isoxazolol
Molecular FormulaC4H6N2O2
Molecular Weight114.10
Purity≥99 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point325.0±27.0 °C at 760 mmHg
Melting Point175-176ºC
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2763-96-4 |
| Catalog No. | 2A-9091670 |
| Chinese Name | 蝇蕈醇 |
| Synonyms | 5-(aminomethyl)-1,2-oxazol-3-one; 5-Aminomethyl-3-hydroxy-isoxazol; PANTHERINE; 5-(Aminomethyl)isoxazol-3(2H)-one; Agarine; 5-Aminomethyl-3-hydroxyisoxazole; 3-Hydroxy-5-aminomethylisoxazole; MFCD00057894; 5-aminomethyl-isoxazol-3-one; Agarin; EINECS 220-430-4; 5-(Aminomethyl)-1,2-oxazol-3(2H)-one; Pantherin; 3-Hydroxy-5-aminomethyl-isoxazole 5-Aminomethyl-3-hydroxy-isoxazole 5-Aminomethyl-3-isoxazolol |
| Molecular Formula | C4H6N2O2 |
| Molecular Weight | 114.10 |
| Purity | ≥99 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 325.0±27.0 °C at 760 mmHg |
| Melting Point | 175-176ºC |
| Appearance | solid |
| Storage Condition | Sealed in a cool, dry environment at 2-8 ºC |
| Packaging | II |
| Application | Agarin is a psychoactive isoxazole and a selective agonist of the neurotransmitter GABA. Muscarine binds GABAA at high- and low-affinity sites (Kd 10 and 270 nM, respectively), stimulating chloride io |
| HTC | 2934999090 |
| PubChem ID | 10509 |
| MDL Number | MFCD00057894 |
| SMILES | [N+H3]Cc1[o]nc(c1)[O-] |
| InChI | 1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) |
| InChI Key | ZJQHPWUVQPJPQT-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/91670_1_2763_96_4.pdf |
| Bioactivity | Muscimol (Agarin), a psychoactive isoxazole, is a selective neurotransmitter GABA agonist. Muscimol Binds GABAA on both high- and low-affinity sites (Kd=10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM. Muscimol passes the blood-brain barrier (BBB) and has memory-disrupting effects[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor References [1]. S M Dunn, et al. Reconstitution of purified GABAA receptors: ligand binding and chloride transporting properties. Biochemistry. 1994 Jan 25;33(3):755-63. [2]. Donna R Ramirez, et al. The role of the GABA(A) agonist muscimol on memory performance: reward contingencies determine the nature of the deficit. Neurobiol Learn Mem. 2005 Nov;84(3):184-91. [3]. M Irifune, et al. Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline. Br J Anaesth. 1999 Oct;83(4):665-7. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 325.0±27.0 °C at 760 mmHg Melting Point 175-176ºC Molecular Formula C4H6N2O2 Molecular Weight 114.103 Flash Point 150.4±23.7 °C Exact Mass 114.042931 PSA 72.28000 LogP -0.93 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.556 InChIKey ZJQHPWUVQPJPQT-UHFFFAOYSA-N SMILES NCc1cc(=O)[nH]o1 |
| Use of | Muscimol (Agarin), a psychoactive isoxazole, is a selective neurotransmitter GABA agonist. Muscimol Binds GABAA on both high- and low-affinity sites (Kd=10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM. Muscimol passes the blood-brain barrier (BBB) and has memory-disrupting effects[1]. Properties Articles71 Name muscimol Synonym More Synonyms Muscimol Biological Activity Description Muscimol (Agarin), a psychoactive isoxazole, is a selective neurotransmitter GABA agonist. Muscimol Binds GABAA on both high- and low-affinity sites (Kd=10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM. Muscimol passes the blood-brain barrier (BBB) and has memory-disrupting effects[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor References [1]. S M Dunn, et al. Reconstitution of purified GABAA receptors: ligand binding and chloride transporting properties. Biochemistry. 1994 Jan 25;33(3):755-63. [2]. Donna R Ramirez, et al. The role of the GABA(A) agonist muscimol on memory performance: reward contingencies determine the nature of the deficit. Neurobiol Learn Mem. 2005 Nov;84(3):184-91. [3]. M Irifune, et al. Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline. Br J Anaesth. 1999 Oct;83(4):665-7. Chemical & Physical Properties Molecular Formula C4H6N2O2 Exact Mass 114.042931 PSA 72.28000 LogP -0.93 Index of Refraction 1.556 InChIKey ZJQHPWUVQPJPQT-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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