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RESINIFERATOXIN structure, CAS 57444-62-9

RESINIFERATOXIN

CAS Number57444-62-9

SynonymsMFCD00135927

Molecular FormulaC37H40O9

Molecular Weight376.90

Purity≥97 (HPLC)%

Density1.35g/cm3

Boiling Point768.7ºC at 760mmHg

Melting Point

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symbol6.1(a)

Signal WordWarning

Cat. No.: 2A-9091668 Purity: ≥97 (HPLC)%
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Quality Control of [ 57444-62-9 ] Purity: ≥97 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number57444-62-9
Catalog No.2A-9091668
Chinese Name树脂毒素
SynonymsMFCD00135927
Molecular FormulaC37H40O9
Molecular Weight376.90
Purity≥97 (HPLC)
Density1.35g/cm3
Boiling Point768.7ºC at 760mmHg
Appearancesolid
Storage ConditionSealed, store at -20 ºC
PackagingII
ApplicationResiniferatoxin ((+)-Resiniferotoxin) is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resin aspergillus can be isolated from Euphorbia resinus plants. Resi
PubChem ID3153148
MDL NumberMFCD00153778
SMILESS=C(N2CCCc3c(cc(c(c3)O)O)C2)NCCc1ccc(cc1)Cl
InChI1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
InChI KeyDRCMAZOSEIMCHM-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbols6.1(a)
MSDSmsds/91668_1_57444_62_9.pdf
BioactivityResiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cardiovascular Disease In Vitro Resiniferatoxin causes prolonged channel opening time and calcium influx, resulting in cytotoxicity to TRPV1-positive pain fibers or cell bodies [1]. In Vivo Resiniferatoxin (2 μg/10 μl; intrathecally into the T2/T3 space; induced heart failure in rats 4 weeks after coronary artery occlusion) significantly and selectively abolishes afferent marker expression (TRPV1 and calcitonin gene-related peptide) in the dorsal horn and reduces hyperactivated CSNA. Resiniferatoxin significantly reverses the prolongation of action potential duration (APD) and APD alternations and reduces the inducibility of ventricular arrhythmias [2]. References [1]. Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel). 2016;9(3):47. Published 2016 Aug 11. [2]. Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836. Chemical & Physical Properties Density 1.35g/cm3 Boiling Point 768.7ºC at 760mmHg Molecular Formula C37H40O9 Molecular Weight 628.71 Flash Point 240.3ºC Exact Mass 628.26700 PSA 120.75000 LogP 4.74470 Index of Refraction 1.643 InChIKey DSDNAKHZNJAGHN-WLJYXNHNSA-N SMILES C=C(C)C12CC(C)C34OC(Cc5ccccc5)(OC1C3C=C(COC(=O)Cc1ccc(O)c(OC)c1)CC1(O)C(=O)C(C)=CC14)O2 Storage condition 20°C
Use ofResiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period[1][2]. Properties Articles43 Name resiniferatoxin Synonym More Synonyms Resiniferatoxin Biological Activity Description Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cardiovascular Disease In Vitro Resiniferatoxin causes prolonged channel opening time and calcium influx, resulting in cytotoxicity to TRPV1-positive pain fibers or cell bodies [1]. References [1]. Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel). 2016;9(3):47. Published 2016 Aug 11. [2]. Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836. Chemical & Physical Properties Molecular Formula C37H40O9 Exact Mass 628.26700 PSA 120.75000 LogP 4.74470 Index of Refraction 1.643 InChIKey DSDNAKHZNJAGHN-WLJYXNHNSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Resiniferatoxin) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Resiniferatoxin) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Resiniferatoxin) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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