CAS Number14215-68-0
SynonymsN-[(3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]acetamide; EINECS 217-321-9; MFCD00065372; N-ACETEYL-D-GALACTOSAMINIDE; N-Acetyl-D-galactosamine; N-acelyl-D-glucosamine; 2-Acetamido-2-deoxy-D-galactose; N-Acetylchondrosamine; N-ACETYL-D-GALACTOSAMINIDE; N-((3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide; ACETYL-D-GALACTOSAMINE; N-Acetyl-D-chondrosamine Hydrate
Molecular FormulaC8H15O6N1
Molecular Weight221.21
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point595.4±50.0 °C at 760 mmHg
Melting Point158-162 °C
AppearanceWhite crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 14215-68-0 |
| Catalog No. | 2A-9085166 |
| Chinese Name | N-乙酰-D-半乳糖胺,水合 |
| Synonyms | N-[(3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]acetamide; EINECS 217-321-9; MFCD00065372; N-ACETEYL-D-GALACTOSAMINIDE; N-Acetyl-D-galactosamine; N-acelyl-D-glucosamine; 2-Acetamido-2-deoxy-D-galactose; N-Acetylchondrosamine; N-ACETYL-D-GALACTOSAMINIDE; N-((3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide; ACETYL-D-GALACTOSAMINE; N-Acetyl-D-chondrosamine Hydrate |
| Molecular Formula | C8H15O6N1 |
| Molecular Weight | 221.21 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 595.4±50.0 °C at 760 mmHg |
| Melting Point | 158-162 °C |
| Appearance | White crystalline powder |
| Storage Condition | 2~8°C |
| Application | N-Acetyl-D-galactosamine (GalNAc) N-Acetyl-D-galactosamine is a terminal essential amino sugar derived from galactose and is involved in the formation of A blood group antigens. N-Acetyl-D-galactosami |
| MDL Number | MFCD00063265 |
| SMILES | CC(=O)NC1C(O)OC(CO)C(O)C1O |
| InChI | InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 |
| InChI Key | OVRNDRQMDRJTHS-CBQIKETKSA-N |
| MSDS | msds/85166_1_14215_68_0.pdf |
| Bioactivity | N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets[1].N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin[2]. Related Catalog Research Areas >> Others In Vitro N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) decreases the expression of occludin mRNA and claudin-3 mRNA by 1.6% and 2.7%[1]. N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) lowers the protein expression of occludin and claudin-3 by 4.3% and 7.2%, respectively[1]. RT-PCR[1] Cell Line: IPEC-J2 cell Concentration: 50 nM Incubation Time: 4 hours Result: Observed a slight reduction in mRNA expression of occludin and claudin-3. Western Blot Analysis[1] Cell Line: IPEC-J2 cell Concentration: 50 nM Incubation Time: 4 hours Result: Alleviated the damage of tight junction expressions at protein level. References [1]. Zhao B, et al. N-Acetyl-d-galactosamine prevents soya bean agglutinin-induced intestinal barrier dysfunction in intestinal porcine epithelial cells. J Anim Physiol Anim Nutr (Berl). 2019 Jul;103(4):1198-1206. [2]. Sadanandan R, et al. Isolation, Purification and Characterisation of a D-galactose and N-acetyl-D-galactosamineSpecific Lectin from Marine Sponge Fasciospongia cavernosa. Protein Pept Lett. 2018;25(9):871-877. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 595.4±50.0 °C at 760 mmHg Melting Point 158-162 °C Molecular Formula C8H15NO6 Molecular Weight 221.208 Flash Point 313.9±30.1 °C Exact Mass 221.089935 PSA 119.25000 LogP -2.48 Vapour Pressure 0.0±3.8 mmHg at 25°C Index of Refraction 1.576 InChIKey OVRNDRQMDRJTHS-CBQIKETKSA-N SMILES CC(=O)NC1C(O)OC(CO)C(O)C1O Storage condition 2~8°C |
| Use of | N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets[1].N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin[2]. Properties Name N-acetyl-D-galactosamine Synonym More Synonyms N-Acetyl-D-galactosamine Biological Activity Description N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets[1].N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin[2]. Related Catalog Research Areas >> Others References [1]. Zhao B, et al. N-Acetyl-d-galactosamine prevents soya bean agglutinin-induced intestinal barrier dysfunction in intestinal porcine epithelial cells. J Anim Physiol Anim Nutr (Berl). 2019 Jul;103(4):1198-1206. [2]. Sadanandan R, et al. Isolation, Purification and Characterisation of a D-galactose and N-acetyl-D-galactosamineSpecific Lectin from Marine Sponge Fasciospongia cavernosa. Protein Pept Lett. 2018;25(9):871-877. Chemical & Physical Properties Molecular Formula C8H15NO6 Exact Mass 221.089935 PSA 119.25000 LogP -2.48 Index of Refraction 1.576 InChIKey OVRNDRQMDRJTHS-CBQIKETKSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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