CAS Number2169-64-4
SynonymsEINECS 218-515-6; 6-AZURD-TA; 6-azauridine-2',3',5'-tri-O-acetate; triacetyl-6-azauridine; ta-azur; cb304; 2',3',5'-TRI-O-ACETYL-6-AZAURIDINE; AZARIBINE; 2',3',5'-triacetyl-6-azauridine
Molecular FormulaC14H17N3O9
Molecular Weight371.31
Density1.6g/cm3
Melting Point99-101ºC(lit.)
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2169-64-4 |
| Catalog No. | 2A-9083192 |
| Chinese Name | 6-氮杂尿苷-2,3,5-三乙酸酯 |
| Synonyms | EINECS 218-515-6; 6-AZURD-TA; 6-azauridine-2',3',5'-tri-O-acetate; triacetyl-6-azauridine; ta-azur; cb304; 2',3',5'-TRI-O-ACETYL-6-AZAURIDINE; AZARIBINE; 2',3',5'-triacetyl-6-azauridine |
| Molecular Formula | C14H17N3O9 |
| Molecular Weight | 371.31 |
| Density | 1.6g/cm3 |
| Melting Point | 99-101ºC(lit.) |
| Storage Condition | Store airtight in a cool, dry warehouse. |
| Application | Azapyridine (2',3',5'-tri-O-acetyl-6-azauridine) is a potent inhibitor of orotidine monophosphate decarboxylase (OMPD). Azobine is an antiviral inhibitor of several RNA viruses and can inhibit viral g |
| MDL Number | MFCD00006471 |
| SMILES | CC(=O)OCC1OC(n2ncc(=O)[nH]c2=O)C(OC(C)=O)C1OC(C)=O |
| InChI Key | QQOBRRFOVWGIMD-OJAKKHQRSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/83192_1_2169_64_4.pdf |
| Bioactivity | Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research[1][2]. Related Catalog Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Research Areas >> Inflammation/Immunology In Vitro Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine; 0-2 μM; 48 hours) is cytotoxic to MDCK cells (MTT: CC50=19.66 μM)[1]. Azaribine has a potent inhibitory effect on BIRFLU proliferation (MDCK cells: EC50=0.29 μM; A549 cells: EC50=0.55 μM) [1]. Azaribine showed inhibitory effects on seasonal H1N1 and H3N2 IAV and IBV during post-treatment of MDCK cells with EC50 of 0.60 μM, 0.77 μM, 0.80 μM, respectively [1]. Azaribine has anti-NC H1N1 effects during post-treatment of 16HBE cells with an EC50 of 1.58 μM[1]. Cell Cytotoxicity Assay[1] Cell Line: MDCK cells Concentration: 0-2 μM Incubation Time: 48 h Result: Had cytotoxicity on MDCK cells (CC50=19.66 μM). References [1]. Jun-Gyu Park, et al. Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses. J Virol. 2020 Mar 17;94(7):e02149-19. [2]. Desarey Morales Vasquez, et al. Identification of Inhibitors of ZIKV Replication. Viruses. 2020 Sep 18;12(9):1041. Chemical & Physical Properties Density 1.6g/cm3 Melting Point 99-101ºC(lit.) Molecular Formula C14H17N3O9 Molecular Weight 371.29900 Exact Mass 371.09600 PSA 155.88000 Index of Refraction 1.621 InChIKey QQOBRRFOVWGIMD-OJAKKHQRSA-N SMILES CC(=O)OCC1OC(n2ncc(=O)[nH]c2=O)C(OC(C)=O)C1OC(C)=O |
| Use of | Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research[1][2]. Properties Name 6-azauridine 2',3',5'-triacetate Synonym More Synonyms 6-AZAURIDINE 2',3',5'-TRIACETATE Biological Activity Description Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research[1][2]. Related Catalog Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Research Areas >> Inflammation/Immunology In Vitro Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine; 0-2 μM; 48 hours) is cytotoxic to MDCK cells (MTT: CC50=19.66 μM)[1]. Azaribine has a potent inhibitory effect on BIRFLU proliferation (MDCK cells: EC50=0.29 μM; A549 cells: EC50=0.55 μM) [1]. Azaribine showed inhibitory effects on seasonal H1N1 and H3N2 IAV and IBV during post-treatment of MDCK cells with EC50 of 0.60 μM, 0.77 μM, 0.80 μM, respectively [1]. Azaribine has anti-NC H1N1 effects during post-treatment of 16HBE cells with an EC50 of 1.58 μM[1]. Cell Cytotoxicity Assay[1] Cell Line: MDCK cells Concentration: 0-2 μM Incubation Time: 48 h Result: Had cytotoxicity on MDCK cells (CC50=19.66 μM). References [1]. Jun-Gyu Park, et al. Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses. J Virol. 2020 Mar 17;94(7):e02149-19. [2]. Desarey Morales Vasquez, et al. Identification of Inhibitors of ZIKV Replication. Viruses. 2020 Sep 18;12(9):1041. Chemical & Physical Properties Molecular Formula C14H17N3O9 Exact Mass 371.09600 PSA 155.88000 Index of Refraction 1.621 InChIKey QQOBRRFOVWGIMD-OJAKKHQRSA-N SMILES CC(=O)OCC1OC(n2ncc(=O)[nH]c2=O)C(OC(C)=O)C1OC(C)=O |
| Transport Info | Product name: Purity: 99.4% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a guarantee as to the properties of this product. The company is not responsible for any damage caused by any operation or contact with the above products. For more terms of use, see invoice or package The reverse side of the mounting strip. |
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