CAS Number113170-55-1
Synonymstrimagnesium,[(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-oxido-5-oxo-2H-furan-4-yl] phosphate; L-Ascorbic Acid 2-Phosphate Sesquimagnesium Salt Hydrate; Magnesium (5R)-5-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-2-oxo-2,5-dihydro-3-furanyl phosphate; MFCD08063372
Molecular FormulaC6H9O9P.3/2Mg
Molecular Weight289.54 (anhydrous basis)
Purity≥95%
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 113170-55-1 |
| Catalog No. | 2A-9007124 |
| Chinese Name | 维生素C磷酸酯镁 |
| Synonyms | trimagnesium,[(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-oxido-5-oxo-2H-furan-4-yl] phosphate; L-Ascorbic Acid 2-Phosphate Sesquimagnesium Salt Hydrate; Magnesium (5R)-5-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-2-oxo-2,5-dihydro-3-furanyl phosphate; MFCD08063372 |
| Molecular Formula | C6H9O9P.3/2Mg |
| Molecular Weight | 289.54 (anhydrous basis) |
| Purity | ≥95 |
| Appearance | powder |
| Storage Condition | Room temperature, dry |
| Application | L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that stimulates collagen expression and formation. L-Ascorbic acid 2-phosphate magnesi |
| HTC | 2835100000 |
| PubChem ID | 329771023 |
| MDL Number | MFCD11045932 |
| SMILES | O=C1O[C@@]([C@@H](O)CO)([H])C([O-])=C1OP([O-])([O-])=O.O=C2O[C@@]([C@@H](O)CO)([H])C([O-])=C2OP([O-])([O-])=O.O.[Mg+2].[Mg+2].[Mg+2] |
| InChI | 1S/2C6H9O9P.3Mg.H2O/c2*7-1-2(8)4-3(9)5(6(10)14-4)15-16(11,12)13;;;;/h2*2,4,7-9H,1H2,(H2,11,12,13);;;;1H2/q;;3*+2;/p-6/t2*2-,4+;;;;/m00..../s1 |
| InChI Key | HKRNHMZODRSAPN-IXNKEUJHSA-H |
| NACRES Code | NA.79 |
| UNSPSC | 12352205 |
| Hazard Symbols | Transport |
| MSDS | msds/7124_1_113170_55_1.pdf |
| Bioactivity | L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Target IC50: alkaline phosphatase (ALP); collagen formation; runx2A[2][3] In Vitro L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1]. L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex[3]. Cell Viability Assay[1] Cell Line: Human corneal endothelial cells (HCECs) Concentration: 0.1 mM; 0.3 mM; 1.5 mM Incubation Time: 2 to 3 weeks with medium exchange every 2 to 3 days Result: Stimulated HCEC cells growth. References [1]. Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7. [2]. Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266(15):9997-10003. [3]. Kyllönen L, et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.Stem Cell Res Ther. 2013 Feb 15;4(1):17. Chemical & Physical Properties Molecular Formula C6H9O9P.3/2Mg Molecular Weight 278.393 Exact Mass 277.967804 PSA 169.22000 InChIKey XYWDYAVMJYSSSG-LEJBHHMKSA-N SMILES O=C1OC(C(O)CO)C(O)=C1OP(=O)(O)O.[Mg] |
| Use of | L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3]. Properties Name L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate Synonym More Synonyms L-Ascorbic acid 2-phosphate magnesium Biological Activity Description L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease IC50: alkaline phosphatase (ALP); collagen formation; runx2A[2][3] References [1]. Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7. [2]. Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266(15):9997-10003. [3]. Kyllönen L, et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.Stem Cell Res Ther. 2013 Feb 15;4(1):17. Chemical & Physical Properties Exact Mass 277.967804 PSA 169.22000 InChIKey XYWDYAVMJYSSSG-LEJBHHMKSA-N SMILES O=C1OC(C(O)CO)C(O)=C1OP(=O)(O)O.[Mg] |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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