CAS Number16980-89-5
Synonymssodium N6,O2'-dibutyryl-O3',O5'-hydroxyphosphoryl-adenosine; N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt; EINECS 241-059-4; N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt; dibutyryl cyclic AMP sodium salt; Bucladesine sodium salt; N-(1-Oxobutyl)adenosine Cyclic 3',5'-(Hydrogen Phosphate)-2'-butanoate Monosodium Salt; sodium dibutyryl camp; sodium salt of N6,2'-O-dibutyryl adenosine 3',5'-cyclic monophosphate; sodium bucladesine; Bucladesine sodium; Dibutyl cAMP sodium salt; Dibutyl cyclic AMP sodium; Sodium dibutyryl 3',5'-cyclic AMP; MFCD00005843; Dibutyryl cAMP sodium salt; sodium N6,O2'-dibutyryl cyclic adenosinemonophosphate; Dibutyryl cyclic-AMP sodium salt; Bucladesine (sodium salt)
Molecular FormulaC18H23N5O8PNa
Molecular Weight491.37
Purity≥96 (HPLC)%
Appearancepowder
EINECS241-059-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 16980-89-5 |
| Catalog No. | 2A-9007348 |
| Chinese Name | 二丁酰环磷腺苷钠 |
| Synonyms | sodium N6,O2'-dibutyryl-O3',O5'-hydroxyphosphoryl-adenosine; N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt; EINECS 241-059-4; N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt; dibutyryl cyclic AMP sodium salt; Bucladesine sodium salt; N-(1-Oxobutyl)adenosine Cyclic 3',5'-(Hydrogen Phosphate)-2'-butanoate Monosodium Salt; sodium dibutyryl camp; sodium salt of N6,2'-O-dibutyryl adenosine 3',5'-cyclic monophosphate; sodium bucladesine; Bucladesine sodium; Dibutyl cAMP sodium salt; Dibutyl cyclic AMP sodium; Sodium dibutyryl 3',5'-cyclic AMP; MFCD00005843; Dibutyryl cAMP sodium salt; sodium N6,O2'-dibutyryl cyclic adenosinemonophosphate; Dibutyryl cyclic-AMP sodium salt; Bucladesine (sodium salt) |
| Molecular Formula | C18H23N5O8PNa |
| Molecular Weight | 491.37 |
| Purity | ≥96 (HPLC) |
| Appearance | powder |
| Water Solubility | H2O: 50 mg/mL |
| Storage Condition | −20°C |
| Application | Bucladesine sodium salt is a cell-permeable cAMP analog that activates cAMP-dependent protein kinase (PKA). |
| EINECS | 241-059-4 |
| HTC | 2934.99.9000 |
| PubChem ID | 24893246 |
| MDL Number | MFCD00005843 |
| SMILES | [Na+].CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3OC(=O)CCC |
| InChI | 1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1 |
| InChI Key | KRBZRVBLIUDQNG-JBVYASIDSA-M |
| NACRES Code | NA.51 |
| UNSPSC | 41106305 |
| Hazard Symbols | Transport |
| MSDS | msds/7348_1_16980_89_5.pdf |
| Bioactivity | Bucladesine sodium salt is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP dependent protein kinase (PKA). Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Others References [1]. Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20. [2]. Azami, K., et al., The quantitative evaluation of cholinergic markers in spatial memory improvement induced by nicotine-bucladesine combination in rats. Eur J Pharmacol, 2010. 636(1-3): p. 102-7. [3]. Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43. [4]. Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012. Chemical & Physical Properties Molecular Formula C18H23N5NaO8P Molecular Weight 491.367 Exact Mass 491.118195 PSA 176.63000 LogP 2.20120 InChIKey KRBZRVBLIUDQNG-JBVYASIDSA-M SMILES CCCC(=O)Nc1ncnc2c1ncn2C1OC2COP(=O)([O-])OC2C1OC(=O)CCC.[Na+] Storage condition −20°C Water Solubility H2O: 50 mg/mL |
| Use of | Bucladesine sodium salt is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP dependent protein kinase (PKA). Properties Articles41 Name Bucladesine Sodium Salt Synonym More Synonyms Bucladesine (sodium salt) Biological Activity Description Bucladesine sodium salt is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP dependent protein kinase (PKA). Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Others References [1]. Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20. [2]. Azami, K., et al., The quantitative evaluation of cholinergic markers in spatial memory improvement induced by nicotine-bucladesine combination in rats. Eur J Pharmacol, 2010. 636(1-3): p. 102-7. [3]. Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43. [4]. Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012. Chemical & Physical Properties Molecular Formula C18H23N5NaO8P Exact Mass 491.118195 PSA 176.63000 LogP 2.20120 InChIKey KRBZRVBLIUDQNG-JBVYASIDSA-M |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Nutritional Ingredients | ||
|---|---|---|
| 4-Oxo-4-(5-oxo-1,4-diazepan-1-yl)butanoic acid | 397244-77-8 | 2A-9006075 |
| 5-Oxo-[1,4]diazepane-1-carboxylic acid benzylester | 18158-16-2 | 2A-9006638 |
| N-Acetyl-DL-tryptophan; Ac-DL-Trp-OH | 87-32-1 | 2A-9007054 |
| alpha-Lipoic acid | 1077-28-7 | 2A-0202056 |
| Ascorbic acid 2-phosphate magnesium ester | 113170-55-1 | 2A-9007124 |
| Calcium phosphorylcholine chloride | 4826-71-5 | 2A-9007357 |
| Carbamyl-beta-methylcholine chloride | 590-63-6 | 2A-9007361 |
| Choline chloride | 67-48-1 | 2A-9007402 |
| D-Glucosamine sulfate potassium | 2A-107532 | 2A-9007532 |
| D-Glucosamine sulfate sodium | 2A-107533 | 2A-9007533 |
| Browse all Nutritional Ingredients products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS