CAS Number4578-31-8
SynonymsDisodium 5'-O-phosphonatoadenosine; Disodium adenosine 5'-phosphate; Adenosine 5'-monophosphate disodium salt; MFCD00065023; Adenosine-5'-monophosphate disodium salt; Dinatrium-9-(5-O-phosphonato-β-D-ribofuranosyl)-9H-purin-6-amin; Adenosine 5′-monophosphate sodium salt; AMP disodium salt; EINECS 224-961-2; 5'-Adenylic acid, sodium salt (1:2); 5'-AMP-Na2; Adenosine 5'-Monophosphate Disodium Salt; 5′-AMP-Na2; Disodium [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl phosphate
Molecular FormulaC10H12N5Na2O7P
Molecular Weight391.18
Purity≥99.0 (HPLC)%
Boiling Point798.5ºC at 760 mmHg
Melting Point232-235ºC
Appearancepowder
EINECS224-961-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4578-31-8 |
| Catalog No. | 2A-9007077 |
| Chinese Name | 腺苷酸二钠盐 |
| Synonyms | Disodium 5'-O-phosphonatoadenosine; Disodium adenosine 5'-phosphate; Adenosine 5'-monophosphate disodium salt; MFCD00065023; Adenosine-5'-monophosphate disodium salt; Dinatrium-9-(5-O-phosphonato-β-D-ribofuranosyl)-9H-purin-6-amin; Adenosine 5′-monophosphate sodium salt; AMP disodium salt; EINECS 224-961-2; 5'-Adenylic acid, sodium salt (1:2); 5'-AMP-Na2; Adenosine 5'-Monophosphate Disodium Salt; 5′-AMP-Na2; Disodium [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl phosphate |
| Molecular Formula | C10H12N5Na2O7P |
| Molecular Weight | 391.18 |
| Purity | ≥99.0 (HPLC) |
| Boiling Point | 798.5ºC at 760 mmHg |
| Melting Point | 232-235ºC |
| Appearance | powder |
| Water Solubility | H2O: soluble |
| Storage Condition | Sealed with argon and stored dry below -20℃. |
| Application | Adenosine 5'-monophosphate disodium is an orally active purine nucleotide involved in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for the adenosine 2B receptor. Adenosine 5'-m |
| EINECS | 224-961-2 |
| HTC | 2934.99.9000 |
| PubChem ID | 329747374 |
| MDL Number | MFCD00065023 |
| SMILES | Nc1ncnc2c1ncn2C1OC(COP(=O)([O-])[O-])C(O)C1O.[Na+].[Na+] |
| InChI | 1S/C10H14N5O7P.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1 |
| InChI Key | QGXLVXZRPRRCRP-IDIVVRGQSA-L |
| Beilstein/REAXYS | 3586732 |
| NACRES Code | NA.51 |
| eCl@ss | 32160414 |
| UNSPSC | 41106305 |
| Hazard Symbols | Transport |
| Safety Description | S22;S24/25 |
| MSDS | msds/7077_1_4578_31_8.pdf |
| Bioactivity | Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3]. Related Catalog Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Target A2BR In Vivo Adenosine 5'-monophosphate (10 and 13 mg/L, added in distilled water, 25 weeks) disodium improves glucose metabolism in HFD-induced diabetic mice[1]. Adenosine 5'-monophosphate (40-800 mg/kg, i.p.) disodium lowers body temperature through adenosine receptors in mice [2]. Animal Model: C57BL/6 J mice with high-fat diet-induced diabetes[1] Dosage: 10 and 13 mg/L Administration: Added in distilled water, for 25 weeks Result: Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle. References [1]. Ardiansyah, et al. Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet. BMC Complement Altern Med. 2018 Nov 14;18(1):304. [2]. Steven J. Swoap, et al. AMP does not induce torpor. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007 293:1, R468-R473. [3]. Holien JK, et al. AMP and adenosine are both ligands for adenosine 2B receptor signaling. Bioorg Med Chem Lett. 2018 Jan 15;28(2):202-206. Chemical & Physical Properties Boiling Point 798.5ºC at 760 mmHg Melting Point 232-235ºC Molecular Formula C10H12N5Na2O7P Molecular Weight 391.185 Flash Point 436.7ºC Exact Mass 391.026978 PSA 201.54000 InChIKey QGXLVXZRPRRCRP-IDIVVRGQSA-L SMILES Nc1ncnc2c1ncn2C1OC(COP(=O)([O-])[O-])C(O)C1O.[Na+].[Na+] Storage condition −20°C Water Solubility H2O: soluble |
| Use of | Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3]. Properties Name Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate Synonym More Synonyms Biological Activity Description Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3]. Related Catalog Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor References [1]. Ardiansyah, et al. Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet. BMC Complement Altern Med. 2018 Nov 14;18(1):304. [2]. Steven J. Swoap, et al. AMP does not induce torpor. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007 293:1, R468-R473. [3]. Holien JK, et al. AMP and adenosine are both ligands for adenosine 2B receptor signaling. Bioorg Med Chem Lett. 2018 Jan 15;28(2):202-206. Chemical & Physical Properties Molecular Formula C10H12N5Na2O7P Exact Mass 391.026978 PSA 201.54000 InChIKey QGXLVXZRPRRCRP-IDIVVRGQSA-L Water Solubility H2O: soluble |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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