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Adenosine triphosphate disodium salt structure, CAS 51963-61-2

Adenosine triphosphate disodium salt

CAS Number51963-61-2

SynonymsEINECS 213-579-1; adenosine-5'-triphosphate disodium trihydrate; disodium adenosine 5'-triphosphate trihydrate; Adenosine-5'-triphosphate disodium salt hydrate,water; ADENOSINE-5'-TRIPHOSPHATE DISODIUM SALT HYDR.,CALCIUM FREE; 5'-ATP-Na2; MFCD00067316; Adenosine 5'-triphosphate disodium salt

Molecular FormulaC10H14N5Na2O13P3

Molecular Weight605.19

Purity≥98%

Density

Boiling Point

Melting Point176ºC

Flash Point

Appearancecrystals

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9007082 Purity: ≥98%
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Quality Control of [ 51963-61-2 ] Purity: ≥98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number51963-61-2
Catalog No.2A-9007082
Chinese Name5'-三磷酸腺苷二钠盐 三水合物
SynonymsEINECS 213-579-1; adenosine-5'-triphosphate disodium trihydrate; disodium adenosine 5'-triphosphate trihydrate; Adenosine-5'-triphosphate disodium salt hydrate,water; ADENOSINE-5'-TRIPHOSPHATE DISODIUM SALT HYDR.,CALCIUM FREE; 5'-ATP-Na2; MFCD00067316; Adenosine 5'-triphosphate disodium salt
Molecular FormulaC10H14N5Na2O13P3
Molecular Weight605.19
Purity≥98
Melting Point176ºC
Appearancecrystals
Water SolubilityH2O: 50 mg/mL
Storage ConditionSeal and store at -20 ºC
ApplicationATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is an important substance for energy storage and metabolism in the body. It provides energy for metabolism and functions as a co
HTC2933.59.0500
PubChem ID329773087
MDL NumberMFCD00150754
SMILESO.O.O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
InChI1S/C10H16N5O13P3.2Na.3H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;3*1H2/q;2*+1;;;/p-2/t4-,6-,7-,10-;;;;;/m1...../s1
InChI KeyMWEQTWJABOLLOS-AZGWGOJFSA-L
NACRES CodeNA.54
UNSPSC41106305
Hazard SymbolsTransport
MSDSmsds/7082_1_51963_61_2.pdf
BioactivityATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease In Vitro ATP disodium trihydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3]. ATP disodium trihydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4]. ATP disodium trihydrate stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4]. In Vivo ATP disodium trihydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4]. ATP disodium trihydrate induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4]. Animal Model: Four-week-old Kunming mice (18-22 g)[4] Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial (E. coli) challenge Result: Protected mice from bacterial infection. References [1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. Chemical & Physical Properties Melting Point 176ºC Molecular Formula C10H14N5Na2O13P3 Molecular Weight 551.145 Exact Mass 550.959656 PSA 314.22000 Appearance of Characters lyophilized powder InChIKey MWEQTWJABOLLOS-AZGWGOJFSA-N SMILES Nc1ncnc2c1ncn2C1OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C1O.O.O.O.[Na+].[Na+] Storage condition −20°C Water Solubility H2O: 50 mg/mL
Use ofATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation[1][2]. Properties Name Adenosine Disodium Triphosphate Synonym More Synonyms ATP disodium trihydrate Biological Activity Description ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease References [1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. Chemical & Physical Properties Molecular Formula C10H14N5Na2O13P3 Exact Mass 550.959656 PSA 314.22000 Appearance of Characters lyophilized powder InChIKey MWEQTWJABOLLOS-AZGWGOJFSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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