CAS Number388082-78-8
SynonymsLapatinib ditosylate (USAN); Lapatinib Ditosilate; Lapatinib ditosylate monohydrate; Lapatinib Ditosylate
Molecular FormulaC43H44O11N4Cl1S3F1
Molecular Weight943.49
Purity98.00%
Density1.403 g/mL (20.84 °C)
Boiling Point750.7ºC at 760 mmHg
Melting Point237 - 239 °C
AppearanceColorless or light yellow crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 388082-78-8 |
| Catalog No. | 2A-9057004 |
| Chinese Name | 二甲苯磺酸拉帕替尼 |
| Synonyms | Lapatinib ditosylate (USAN); Lapatinib Ditosilate; Lapatinib ditosylate monohydrate; Lapatinib Ditosylate |
| Molecular Formula | C43H44O11N4Cl1S3F1 |
| Molecular Weight | 943.49 |
| Purity | 98.00 |
| Density | 1.403 g/mL (20.84 °C) |
| Boiling Point | 750.7ºC at 760 mmHg |
| Melting Point | 237 - 239 °C |
| Appearance | Colorless or light yellow crystal |
| Storage Condition | room temperature |
| Application | Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of ErbB-2 and EGFR tyrosine kinase domains, with IC50 values of 10.2 and 9.8 nM for purified EGFR and ErbB-2, |
| MDL Number | MFCD18904381 |
| SMILES | CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)O)cc1.O |
| InChI | InChI=1S/C29H26ClFN4O4S.2C6H6O3S.H2O/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*7-10(8,9)6-4-2-1-3-5-6;/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*1-5H,(H,7,8,9);1H2 |
| InChI Key | XNRVGTHNYCNCFF-UHFFFAOYSA-N |
| MSDS | msds/57004_1_388082_78_8.pdf |
| Transport Info | Product name: Lapatinib di-p-toluenesulfonate hydrate |
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