| Chemical & Physical Properties | |
|---|---|
| CAS Number | 376348-65-1 |
| Catalog No. | 2A-9056938 |
| Chinese Name | 马拉维若 |
| Synonyms | Maraviroc; maroviroc; Celsentri |
| Molecular Formula | C29H41F2N5O |
| Molecular Weight | 513.666 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Melting Point | 79-81ºC |
| Appearance | brown solid |
| Storage Condition | Store at +4°C |
| Application | Maraviroc is a selective CCR5 antagonist with HIV inhibitory activity. |
| HTC | 2934999090 |
| SMILES | CC(C)c1nnc(C)n1C2C[C@H]3CC[C@@H](C2)N3CC[C@H](NC(=O)C4CCC(F)(F)CC4)c5ccccc5 |
| InChI | InChI=1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25-,26-/m0/s1 |
| InChI Key | InChIKey=GSNHKUDZZFZSJB-QYOOZWMWSA-N |
| MSDS | msds/56938_1_376348_65_1.pdf |
| Use of | Maraviroc is a selective CCR5 antagonist with activity against human HIV. Properties Name maraviroc Synonym More Synonyms Maraviroc Biological Activity Description Maraviroc is a selective CCR5 antagonist with activity against human HIV. Related Catalog Signaling Pathways >> GPCR/G Protein >> CCR Signaling Pathways >> Immunology/Inflammation >> CCR Signaling Pathways >> Anti-infection >> HIV Research Areas >> Inflammation/Immunology References [1]. Dorr P, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005 Nov;49(11):472 [2]. Mencarelli A, et al. Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis. Sci Rep. 2016 Aug 5;6:30802. [3]. Romero-Sánchez MC, et al. Effect of maraviroc on HIV-disease progression-related biomarkers. Antimicrob Agents Chemother. 2012 Nov;56(11):5858-64. [4]. Huilin Mou, et al. NRSF and CCR5 Established Neuron-glia Communication during Acute and Chronic Stresses. Journal of Drug Metabolism & Toxicology. January 10, 2016. Chemical & Physical Properties Molecular Formula C29H41F2N5O Exact Mass 513.327942 PSA 63.05000 Index of Refraction 1.628 Safety Information Hazard Codes Xn Safety Phrases 22-36 RIDADR NONH for all modes of transport HS Code 2934999090 Precursor & DownStream Precursor 10 CAS#:376348-78-6 4,4-DIFLUORO-N-... CAS#:423165-08-6 3-(3-Isopropyl-... CAS#:423165-07-5 (1R,3s,5S)-3-(3... CAS#:376348-71-9 (1S)-3-[3-(3-Is... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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