| Chemical & Physical Properties | |
|---|---|
| CAS Number | 361442-04-8 |
| Catalog No. | 2A-9056828 |
| Chinese Name | 沙克列汀 |
| Synonyms | Onglyza; saxagliptin |
| Molecular Formula | C18H25N3O2 |
| Molecular Weight | 315.42 |
| Purity | 98.00 |
| Density | 1.35 |
| Boiling Point | 548.7±35.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Saxagliptin (BMS477118) is a selective and reversible DPP4 inhibitor with IC50 and Ki of 26 nM and 1.3 nM respectively. |
| HTC | 2933990090 |
| MDL Number | C18H25N3O2 |
| SMILES | N#CC1CC2CC2N1C(=O)C(N)C12CC3CC(CC(O)(C3)C1)C2 |
| InChI Key | QGJUIPDUBHWZPV-UHFFFAOYSA-N |
| MSDS | msds/56828_1_361442_04_8.pdf |
| Use of | Properties Name Saxagliptin Synonym More Synonyms saxagliptin Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease References [1]. Tahrani AA, et al. Saxagliptin: a dipeptidyl peptidase-4 inhibitor in the treatment of type 2 diabetes mellitus By Dave, Darshan J. From Journal of Pharmacology and Pharmacotherapeutics (2011), 2(4), 230-235. [2]. Richter B, et al. Emerging role of dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes. Vasc Health Risk Manag. 2008;4(4):753-68. [3]. Deacon CF, et al. Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Adv Ther. 2009 May;26(5):488-99. [4]. Augeri DJ, et al. Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005 Jul 28;48(15):5025-37. Chemical & Physical Properties Molecular Formula C18H25N3O2 Exact Mass 315.194672 PSA 90.35000 LogP -0.14 Index of Refraction 1.640 InChIKey QGJUIPDUBHWZPV-UHFFFAOYSA-N Storage condition -20℃ Safety Information Hazard Codes Xn Risk Phrases 28-38-41-48 RIDADR 3077 HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Peramivir | 330600-85-6 | 2A-9056613 |
| Avanafil | 330784-47-9 | 2A-9056616 |
| Sunitinib malate | 341031-54-7 | 2A-9056689 |
| tert-Butyl rosuvastatin | 355806-00-7 | 2A-9056797 |
| Pemetrexed disodium hydrate | 357166-30-4 | 2A-9056804 |
| Doripenem hydrate | 364622-82-2 | 2A-9056840 |
| Rivaroxaban | 366789-02-8 | 2A-9056856 |
| Varenicline tartrate | 375815-87-5 | 2A-9056934 |
| Maraviroc | 376348-65-1 | 2A-9056938 |
| Desvenlafaxine succinate | 386750-22-7 | 2A-9056992 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS