| Chemical & Physical Properties | |
|---|---|
| CAS Number | 330784-47-9 |
| Catalog No. | 2A-9056616 |
| Chinese Name | 阿伐那非 |
| Synonyms | Stendra; Avanafil; TA-1790 |
| Molecular Formula | C23H26ClN7O3 |
| Molecular Weight | 483.95 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Melting Point | 150-152ºC |
| Appearance | powder |
| Storage Condition | Refrigerator |
| Application | Avanafil (TA-1790) is a highly active PDE-5 inhibitor with an IC50 of 5.2 nM and low activity against PDE1, PDE6 and PDE11. |
| HTC | 2933990090 |
| MDL Number | MFCD11977961 |
| SMILES | Clc1c(ccc(c1)CNc2nc(ncc2C(=O)NCc4ncccn4)N3[C@@H](CCC3)CO)OC |
| InChI | 1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1 |
| InChI Key | WEAJZXNPAWBCOA-INIZCTEOSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/56616_1_330784_47_9.pdf |
| Use of | Properties Name avanafil Synonym More Synonyms Avanafil Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Cardiovascular Disease References [1]. Kotera J, et al. Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction. J Urol. 2012 Aug;188(2):668-74. [2]. Wang R, et al. Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability. J Sex Med. 2012 Aug;9(8):2122-9. [3]. Mochida H, et al. Avanafil, a highly selective phosphodiesterase type 5 inhibitor for erectile dysfunction, shows good safety profiles for retinal function and hemodynamics in anesthetized dogs. J Urol. 2013 Aug;190(2):799-806. Chemical & Physical Properties Exact Mass 483.178558 PSA 125.39000 Index of Refraction 1.651 Storage condition Refrigerator Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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