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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 1-Amino-11-azido-3,6,9-trioxaundecane
1-Amino-11-azido-3,6,9-trioxaundecane structure, CAS 134179-38-7

1-Amino-11-azido-3,6,9-trioxaundecane

CAS Number134179-38-7

SynonymsAzido-PEG3-Amine; Amino-PEG3-Azide; 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanamine; 1-Amino-11-azido-3,6,9-trioxaundecane; 11-Amino-3,6,9-trioxaundecanyl Azide

Molecular FormulaC8H18N4O3

Molecular Weight218.25

Purity≥90 (GC)%

Density1.1

Boiling Point198-202ºC

Melting Point

Flash Point

Appearanceliquid

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-9052337 Purity: ≥90 (GC)%
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Quality Control of [ 134179-38-7 ] Purity: ≥90 (GC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number134179-38-7
Catalog No.2A-9052337
Chinese Name11-叠氮-3,6,9-三氧杂十一烷-1-胺
SynonymsAzido-PEG3-Amine; Amino-PEG3-Azide; 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanamine; 1-Amino-11-azido-3,6,9-trioxaundecane; 11-Amino-3,6,9-trioxaundecanyl Azide
Molecular FormulaC8H18N4O3
Molecular Weight218.25
Purity≥90 (GC)
Density1.1
Boiling Point198-202ºC
Appearanceliquid
Storage ConditionAmber Vial, Refrigerator, Under Inert Atmosphere
PackagingIII
ApplicationAmino-PEG3-C2-Azido is a PEG-based PROTAC linker for the synthesis of the PARP1 degrader iRucaparib-TP3.
HTC2929909090
PubChem ID57647613
MDL NumberMFCD00269874
SMILESNCCOCCOCCOCCN=[N+]=[N-]
InChI1S/C8H18N4O3/c9-1-3-13-5-7-15-8-6-14-4-2-11-12-10/h1-9H2
InChI KeyFPVCVHVTMPCZTH-UHFFFAOYSA-N
Beilstein/REAXYS4745506
NACRES CodeNA.22
UNSPSC12352125
Hazard Symbolstransportation
MSDSmsds/52337_1_134179_38_7.pdf
BioactivityAmino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro Pomalidomide (a CRBN ligand and a known immunomodulatory imide drug (IMiD)) is conjugated to Rucaparib through a tri(ethylene glycol) (PEG3) linker to afford a compound that we designate as iRucaparib-TP3 (IMiD-Rucaparib with a triazole-PEG3 linker). iRucaparib-TP3 induces PARP1 degradation[1]. References [1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231. Chemical & Physical Properties Density 1.1 Boiling Point 198-202ºC Molecular Formula C8H18N4O3 Molecular Weight 218.25400 Exact Mass 218.13800 PSA 103.46000 LogP 0.45826 Index of Refraction 1.47 InChIKey FPVCVHVTMPCZTH-UHFFFAOYSA-N SMILES [N-]=[N+]=NCCOCCOCCOCCN Storage condition Amber Vial, Refrigerator, Under Inert Atmosphere
Use ofAmino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1]. Properties Name 11-Azido-3,6,9-trioxaundecan-1-amine Synonym More Synonyms Amino-PEG3-C2-Azido Biological Activity Description Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker References [1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231. Chemical & Physical Properties Molecular Formula C8H18N4O3 Exact Mass 218.13800 PSA 103.46000 LogP 0.45826 Index of Refraction 1.47 InChIKey FPVCVHVTMPCZTH-UHFFFAOYSA-N SMILES [N-]=[N+]=NCCOCCOCCOCCN Storage condition Amber Vial, Refrigerator, Under Inert Atmosphere
Tax Rebate9.0%
SupervisionNone MFN tariff: 6.5% Ordinary tariff: 30.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2735 International Dangerous Regulations for sea transport: 2735 International Dangerous Regulations for air transport: 2735 14.2 United Nations shipping name European Land Transport Dangerous Regulations: AMINES, LIQUID, CORROSIVE, N.O.S. (11-Azido-3,6,9-troxaundecan-1-amine) IMDG Code: AMINES, LIQUID, CORROSIVE, N.O.S. (11-Azido-3,6,9-troxaundecan-1-amine) International air transport hazard regulations: Amines, liquid, corrosive, n.o.s. (11-Azido-3,6,9-troxaundecan-1-amine) 14.3 Transport hazard categories European Dangerous Regulations for land transport: 8 International Dangerous Regulations for sea transport: 8 International Dangerous Regulations for air transport: 8 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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