CAS Number82248-59-7
SynonymsAtomoxetine HCL; benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride; (gR)-N-Methyl-g-(2-methylphenoxy)benzenepropanamine Hydrochloride; (3R)-N-méthyl-3-(2-méthylphénoxy)-3-phénylpropan-1-amine chlorhydrate; MFCD06410992; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride (1:1); Atomoxetine hydrochloride; EINECS 200-659-6; (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-aminhydrochlorid; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine hydrochloride (1:1); Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride (1:1); Atomoxetine (hydrochloride)
Molecular FormulaC17H22ClNO
Molecular Weight291.82
Purity98.00%
Boiling Point389ºC at 760 mmHg
Melting Point167-169ºC
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 82248-59-7 |
| Catalog No. | 2A-9048718 |
| Chinese Name | 盐酸托莫西汀 |
| Synonyms | Atomoxetine HCL; benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride; (gR)-N-Methyl-g-(2-methylphenoxy)benzenepropanamine Hydrochloride; (3R)-N-méthyl-3-(2-méthylphénoxy)-3-phénylpropan-1-amine chlorhydrate; MFCD06410992; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride (1:1); Atomoxetine hydrochloride; EINECS 200-659-6; (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-aminhydrochlorid; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine hydrochloride (1:1); Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride (1:1); Atomoxetine (hydrochloride) |
| Molecular Formula | C17H22ClNO |
| Molecular Weight | 291.82 |
| Purity | 98.00 |
| Boiling Point | 389ºC at 760 mmHg |
| Melting Point | 167-169ºC |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Application | Atomoxetine (LY 139603; Tomoxetine) hydrochloride is a norepinephrine reuptake inhibitor with Ki of 5, 77 and 1451 nM for radioligand binding to human NET, SERT and DAT respectively. |
| HTC | 2922299090 |
| PubChem ID | 329831496 |
| SMILES | CNCCC(Oc1ccccc1C)c1ccccc1.Cl |
| InChI | InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1 |
| InChI Key | LUCXVPAZUDVVBT-UNTBIKODSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Atomoxetine Hcl(LY 139603; Tomoxetine Hcl) is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). IC50 value: 5 nM (Ki for human NET)Target: NETAtomoxetine displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Atomoxetine is antidepressant and a commonly used non-stimulant treatment for Attention deficit hyperactivity disorder (ADHD). Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. McAfee AT, Landon J, Jones M, et al. A cohort study of the risk of seizures in a pediatric population treated with atomoxetine or stimulant medications. Pharmacoepidemiol Drug Saf. 2012 Dec 26. [2]. Turner M, Wilding E, Cassidy E, Dommett EJ. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2012 Dec 22;243C:28-37. [3]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 N [4]. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther. 1997 Dec;283(3):1305-22. [5]. Atomoxetine Chemical & Physical Properties Boiling Point 389ºC at 760 mmHg Melting Point 167-169ºC Molecular Formula C17H22ClNO Molecular Weight 291.816 Flash Point 164.1ºC Exact Mass 291.138977 PSA 21.26000 LogP 4.91750 InChIKey LUCXVPAZUDVVBT-UNTBIKODSA-N SMILES CNCCC(Oc1ccccc1C)c1ccccc1.Cl Storage condition 2-8°C |
| Use of | Atomoxetine Hcl(LY 139603; Tomoxetine Hcl) is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). IC50 value: 5 nM (Ki for human NET)Target: NETAtomoxetine displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Atomoxetine is antidepressant and a commonly used non-stimulant treatment for Attention deficit hyperactivity disorder (ADHD). Properties Articles45 Name atomoxetine hydrochloride Synonym More Synonyms Atomoxetine Hydrochloride Biological Activity Description Atomoxetine Hcl(LY 139603; Tomoxetine Hcl) is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). IC50 value: 5 nM (Ki for human NET)Target: NETAtomoxetine displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Atomoxetine is antidepressant and a commonly used non-stimulant treatment for Attention deficit hyperactivity disorder (ADHD). Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. McAfee AT, Landon J, Jones M, et al. A cohort study of the risk of seizures in a pediatric population treated with atomoxetine or stimulant medications. Pharmacoepidemiol Drug Saf. 2012 Dec 26. [3]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 N [4]. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther. 1997 Dec;283(3):1305-22. [5]. Atomoxetine Chemical & Physical Properties Exact Mass 291.138977 PSA 21.26000 LogP 4.91750 InChIKey LUCXVPAZUDVVBT-UNTBIKODSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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