| Chemical & Physical Properties | |
|---|---|
| CAS Number | 83898-65-1 |
| Catalog No. | 2A-9048955 |
| Chinese Name | 马来酸多潘立酮 |
| Synonyms | Domperidone (TN); Prestwick-06G02; Domperidone Maleate |
| Molecular Formula | C26H28ClN5O6 |
| Molecular Weight | 541.98 |
| Purity | 98.00 |
| Application | Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and prokinetic agent through its effects on the chemore |
| HTC | 2942000000 |
| SMILES | O=C(O)C=CC(=O)O.O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1 |
| InChI | InChI=1S/C22H24ClN5O2.C4H4O4/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29;5-3(6)1-2-4(7)8/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30);1-2H,(H,5,6)(H,7,8)/p-2/b;2-1- |
| InChI Key | OAUUYDZHCOULIO-BTJKTKAUSA-N |
| Use of | Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1]. Properties Name domperidone maleate Synonym More Synonyms Biological Activity Description Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease In Vivo Unlike Metoclopramide, Domperidone monomaleate does not cause any adverse neurological symptoms as it has minimal penetration through the blood-brain barrier[1]. Domperidone monomaleate acts as both an antiemetic and an upper gastrointestinal tract prokinetic agent. It is rapidly absorbed after oral administration, and few side effects have been reported[2]. References [1]. Reddymasu SC, et al. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102(9):2036-2045. [2]. Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135(5):457-461. [3]. Stoetzer C, et al. Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels. Anesth Analg. 2017 Jan. 124(1):52-60. Chemical & Physical Properties Exact Mass 541.17300 PSA 153.42000 LogP 3.00290 InChIKey OAUUYDZHCOULIO-BTJKTKAUSA-N Safety Information HS Code 2942000000 |
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