CAS Number80214-83-1
SynonymsRoxid; Overal; Forilin; MFCD00214389; Roxithromycin; Claramid; biaxsig; RU 965; Assoral; roxyithromycin; Brilid; Rulid; Surlid
Molecular FormulaC41H76N2O15
Molecular Weight837.05
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point864.7±75.0 °C at 760 mmHg
Melting Point115- 120ºC
AppearanceWhite crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 80214-83-1 |
| Catalog No. | 2A-9048458 |
| Chinese Name | 罗红霉素 |
| Synonyms | Roxid; Overal; Forilin; MFCD00214389; Roxithromycin; Claramid; biaxsig; RU 965; Assoral; roxyithromycin; Brilid; Rulid; Surlid |
| Molecular Formula | C41H76N2O15 |
| Molecular Weight | 837.05 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 864.7±75.0 °C at 760 mmHg |
| Melting Point | 115- 120ºC |
| Appearance | White crystalline powder |
| Storage Condition | 2-8°C |
| Application | Roxithromycin is a semi-synthetic macrolide antibiotic. |
| HTC | 2941500000 |
| PubChem ID | 329824004 |
| MDL Number | MFCD00214389 |
| SMILES | CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=N/OCOCCOC)\C(C)C(O)C1(C)O |
| InChI | 1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+ |
| InChI Key | RXZBMPWDPOLZGW-FEMONOMJSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/48458_1_80214_83_1.pdf |
| Use of | Roxithromycin is a semi-synthetic macrolide antibiotic.Target: AntibacterialRoxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. From Wikipedia. Properties Articles63 Name (E)-roxithromycin Synonym More Synonyms Roxithromycin Biological Activity Description Roxithromycin is a semi-synthetic macrolide antibiotic.Target: AntibacterialRoxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. From Wikipedia. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. http://en.wikipedia.org/wiki/Roxithromycin Chemical & Physical Properties Molecular Formula C41H76N2O15 Exact Mass 836.524597 PSA 216.89000 Index of Refraction 1.535 InChIKey RXZBMPWDPOLZGW-CCQYYCFZSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Erythromycin, 9-O-((2-methoxyethoxy)methyl)oxime CAS REGISTRY NUMBER : 80214-83-1 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C41-H76-N2-O15 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 36(Suppl 4),94,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1471,1995 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1471,1995 Safety Information Signal Word Warning Hazard Statements H302 Precautionary Statements P301 + P312 + P330 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn:Harmful Risk Phrases R22 Safety Phrases 26 RIDADR NONH for all modes of transport RTECS KF4990000 HS Code 2941500000 Synthetic Route Total: 1 Page 1-(Chloromethox... CAS#:3970-21-6 Erythromycin A Oxime CAS#:13127-18-9 Roxithromycin CAS#:80214-83-1 Literature: EP1435359 A1, ; Page 5 ; Precursor & DownStream Precursor 2 CAS#:3970-21-6 1-(Chloromethox... CAS#:13127-18-9 Erythromycin A Oxime DownStream 0 |
| Transport Info | Product Name: Roxithromycin |
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