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Pergolide mesylate salt structure, CAS 66104-23-2

Pergolide mesylate salt

CAS Number66104-23-2

SynonymsPergolide methanesulfonate salt; Ergoline; Pergolide mesilate; Celance; Ergoline, 8-[(methylthio)methyl]-6-propyl-, (8β)-, methanesulfonate (1:1); (8β)-8-[(methylsulfanyl)methyl]-6-propylergoline methanesulfonate; MFCD00153859; UNII-55B9HQY616; Permax; 8-b-((Methylthio)methyl)-6-propylergoline Methanesulfonate; Pergolide mesylate; (8β)-8-[(Methylsulfanyl)methyl]-6-propylergoline methanesulfonate (1:1); Pergolide mesylate salt; 8b-((Methylthio)methyl)-6-propylergoline Monomethanesulfonate; Pergolide methanesulfonate; Pergolide (mesylate)

Molecular FormulaC20H30N2O3S2

Molecular Weight410.594

Purity98.00%

Density

Boiling Point491.3ºC at 760 mmHg

Melting Point252-254°C

Flash Point

AppearanceWhite to off-white solid

EINECS

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Symbol

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Cat. No.: 2A-9046381 Purity: 98.00%
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Quality Control of [ 66104-23-2 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number66104-23-2
Catalog No.2A-9046381
Chinese Name甲磺酸培高利特
SynonymsPergolide methanesulfonate salt; Ergoline; Pergolide mesilate; Celance; Ergoline, 8-[(methylthio)methyl]-6-propyl-, (8β)-, methanesulfonate (1:1); (8β)-8-[(methylsulfanyl)methyl]-6-propylergoline methanesulfonate; MFCD00153859; UNII-55B9HQY616; Permax; 8-b-((Methylthio)methyl)-6-propylergoline Methanesulfonate; Pergolide mesylate; (8β)-8-[(Methylsulfanyl)methyl]-6-propylergoline methanesulfonate (1:1); Pergolide mesylate salt; 8b-((Methylthio)methyl)-6-propylergoline Monomethanesulfonate; Pergolide methanesulfonate; Pergolide (mesylate)
Molecular FormulaC20H30N2O3S2
Molecular Weight410.594
Purity98.00
Boiling Point491.3ºC at 760 mmHg
Melting Point252-254°C
AppearanceWhite to off-white solid
Storage ConditionStore in an airtight container in a cool, dry plac
ApplicationPergolide mesylate is a dopamine receptor agonist with anti-Parkinsonian properties.
PubChem ID456862
SMILESCCCN1CC(CSC)CC2c3cccc4[nH]cc(c34)CC21.CS(=O)(=O)O
InChIInChI=1S/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1
InChI KeyUWCVGPLTGZWHGS-ZORIOUSZSA-N
BioactivityPergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.Target: Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Pergolide mesylate functions as an agonist at the dopamine D2, D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may possess agonist activity at other dopamine receptor subtypes as well, similar to cabergoline [1, 2]. Pergolide mesylate decreases plasma prolactin concentrations [3]. The weak agonist activity of pergolide at D1 receptors somewhat alters its clinical and side effect profile in the treatment of Parkinson's disease. The drug is in decreasing use, as it is reported to be associated with a form of heart disease called cardiac fibrosis. The use of pergolide or cabergoline is associated with a significantly increased risk of newly diagnosed cardiac-valve regurgitation [4]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Lemberger, L. and R.E. Crabtree, Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist. Science, 1979. 205(4411): p. 1151-3. [2]. Koller, W.C., et al., The pharmacological evaluation of pergolide mesylate as a potential anti-parkinson agent. Neuropharmacology, 1980. 19(9): p. 831-7. [3]. Franks, S., et al., Effectiveness of pergolide mesylate in long term treatment of hyperprolactinaemia. British medical journal (Clinical research ed.), 1983. 286(6372): p. 1177. [4]. Schade, R., et al., Dopamine agonists and the risk of cardiac-valve regurgitation. N Engl J Med, 2007. 356(1): p. 29-38. Chemical & Physical Properties Boiling Point 491.3ºC at 760 mmHg Melting Point 252-254°C Molecular Formula C20H30N2O3S2 Molecular Weight 410.594 Flash Point 250.9ºC Exact Mass 410.169769 PSA 107.08000 LogP 4.79380 InChIKey UWCVGPLTGZWHGS-ZORIOUSZSA-N SMILES CCCN1CC(CSC)CC2c3cccc4[nH]cc(c34)CC21.CS(=O)(=O)O Storage condition −20°C
Use ofProperties Articles29 Name pergolide mesylate Synonym More Synonyms Pergolide mesylate salt Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Lemberger, L. and R.E. Crabtree, Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist. Science, 1979. 205(4411): p. 1151-3. [2]. Koller, W.C., et al., The pharmacological evaluation of pergolide mesylate as a potential anti-parkinson agent. Neuropharmacology, 1980. 19(9): p. 831-7. [3]. Franks, S., et al., Effectiveness of pergolide mesylate in long term treatment of hyperprolactinaemia. British medical journal (Clinical research ed.), 1983. 286(6372): p. 1177. [4]. Schade, R., et al., Dopamine agonists and the risk of cardiac-valve regurgitation. N Engl J Med, 2007. 356(1): p. 29-38. Chemical & Physical Properties Molecular Formula C20H30N2O3S2 Exact Mass 410.169769 PSA 107.08000 LogP 4.79380 InChIKey UWCVGPLTGZWHGS-ZORIOUSZSA-N
Transport InfoProduct name: Pergolide mesylate
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